- Reaction score
- 3,656
MDV-3100 (Enzalutamide) - triple action AR antagonist
(https://en.wikipedia.org/wiki/Enzalutamide)
MECHANISM OF ACTION
1) Blocks binding of DHT to the androgen receptor(https://en.wikipedia.org/wiki/Enzalutamide)
MECHANISM OF ACTION
2) Impedes movement of the AR into the cell nucleus
3) Reduces ability of AR to interact with DNA
See image (click to open):
USAGE GUIDELINES
USAGE GUIDELINES
Frequency of application: 2-3x weekly due to long serum half-life
Dosage per application: to be determined
The ideal dose will be determined through user experimentation but will also likely remain somewhat individual.
A good starting percentage is 2%, which depending on the amount of scalp to be covered, can be between 20 - 60 mg of MDV used per application.
HOW LONG WILL IT LAST?
Of course, it depends how much is used. As an example, when used at 2%, with 3 mL to cover the entire scalp, means using about 60 mg, and due to the half-life not recommended to use more than 2-3x weekly, 5 g would last you approx. 250 days (>8 months).
STORAGE (IMPORTANT!)
Just like with similar anti-androgens, the raw powder should ideally be kept in a freezer at a temperature of -20°c (-4°F), in which conditions it can last up to 3 years.
(reference: http://www.selleckchem.com/products/MDV3100.html)
The finished solution should be kept refrigerated (-4°c / 24.8°F) in batches up to 2 weeks.
(reference: http://www.eurodiagnostico.com/media/pdf/MDV3100 (Enzalutamide).pdf)
MAKING A SOLUTION
KNOWN SOLVENTS: PEG (polyethylene glycol)-400, DMSO
WILL NOT DISSOLVE IN ETHANOL!
VEHICLE 1
30% PEG-400
40% Ethanol 96%
30% Distilled water
VEHICLE 2
10% DMSO
70% Ethanol 96%
20% Distilled water
VEHICLE 3
20% PEG-400
30% Ethanol 96%
30% Propylene glycol
20% Distilled water
ORIGINAL THREAD
I was doing some research and came across this relatively new anti-androgen called Enzalutamide, codename MDV3100.
A post on baldtruthtaIk by a guy named Xandrus who claimed using it went relatively under the radar:
https://www.baldtruthtaIk.com/threads/23023-My-treatment-works-only-RU58841-5-10-and-MDV3100-2
->
(I took the liberty of linking to his progress photos, hope you don't mind, if you are reading this, Xandrus)
He claims using a 2% solution of MDV3100 returned him from NW4 to NW2 in 5 months. The best part is he only used this 3x weekly, every OTHER week. So basically, he used this stuff only 6x a month, in combination with RU58841 (prior to that he used RU alone and got no regrowth).
He made a topical solution with Alcohol, glycerol and water after buying the chemical from AliBaba.
MDV3100 is a very powerful antiandrogen, more powerful than RU58841 and with better and stronger effects that most typical anti-androgens cannot achieve (it actually has potential for regrowth, that is how powerful it is):
http://www.avacor.com/blog/hair-regrowth/the-future-of-hair-regrowth-part-2-–-next-generation-ar-antagonists/
And, best of all, he claims no side effects. After this post he disappeared from the forum - perhaps this man really cured himself and has no reason to come back there anymore. I wonder if he kept using the stuff and is maybe a NW1 now in 2017.
The stuff is fairly expensive to buy in one chunk but comes out to about 50$ monthly at the dosing that he used.
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