Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical

[whatevr]

To avoid it from going systemic, couldn't you "cycle" it maybe? Im assuming it goes systemic after a while?

With the half-life being 8 freaking days you'd have to be crazy to even use it more than 3x a week, even that is probably too much.
Xandrus used it 6 times a MONTH and regained two norwoods. Stuff is crazy powerful and should be used very sparingly.
If I don't manage to get to NW1 with RU I will probably get some of this stuff, get to NW1 and then maintain with RU.

 

[resu]

With the half-life being 8 freaking days you'd have to be crazy to even use it more than 3x a week, even that is probably too much.
Xandrus used it 6 times a MONTH and regained two norwoods. Stuff is crazy powerful and should be used very sparingly.
If I don't manage to get to NW1 with RU I will probably get some of this stuff, get to NW1 and then maintain with RU.

No one got regrowth from RU alone so it's already a small goal to surpass.

 

[Prada1]

With the half-life being 8 freaking days you'd have to be crazy to even use it more than 3x a week, even that is probably too much.
Xandrus used it 6 times a MONTH and regained two norwoods. Stuff is crazy powerful and should be used very sparingly.
If I don't manage to get to NW1 with RU I will probably get some of this stuff, get to NW1 and then maintain with RU.

Yeah well I guess thats the risk of taking something when he have little info but Im thinking even if you take it maybe once a week, it could possible help a lot, while minimizing the negative sides. Unfortunately even if one of us were to experiment with it we are all stuck waiting 4,5,6,12 months for visible results.

 

[whatevr]

No one got regrowth from RU alone so it's already a small goal to surpass.

Well sh*t, I guess that's another record I'm already breaking.

I don't think I will move down two norwoods, but I am definitely seeing thickening.

 

[kawnshawn]

Well I was able to get a hold of some Enzalutamide but there are issues. From what I have come to understand is that the solubility is 1mg/mL in ethanol which is way to low. On the other hand its solubility is 92 mg/mL when used with DMSO. The problem with that is it will definitely 100% go systemic.

Maybe mixing first with DMSO and then mixing with ethanol when its dissolve would work? Any input? The sooner I find out the sooner I can post results.

Edit: Well I tested it out. In alcohol it hardly dissolves and is left as a hazy cloud. In DMSO in nearly dissolves instantly while remaining clear.

 

[abcdefg]

Something like this is essentially a cure to male pattern baldness if you could keep it local somehow. Why is there no way to just locally use something like this and keep it isolated to just the scalp? Are hair androgen receptors any different than others found elsewhere in body?
Something like this can block T and DHT which most treatments dont do. I think blocking T could make a big difference in certain areas like temples or front where we know propecia/dutasteride dont work as well as they do other areas.

 

[whatevr]

Well I was able to get a hold of some Enzalutamide but there are issues. From what I have come to understand is that the solubility is 1mg/mL in ethanol which is way to low. On the other hand its solubility is 92 mg/mL when used with DMSO. The problem with that is it will definitely 100% go systemic.

Maybe mixing first with DMSO and then mixing with ethanol when its dissolve would work? Any input? The sooner I find out the sooner I can post results.

Edit: Well I tested it out. In alcohol it hardly dissolves and is left as a hazy cloud. In DMSO in nearly dissolves instantly while remaining clear.

I think you should follow the same basic formulation Xandrus used for a start. Don't mess with DMSO.
Ethanol seemed to work fine for him so I'd try that first.

 

[kawnshawn]

I think you should follow the same basic formulation Xandrus used for a start. Don't mess with DMSO.
Ethanol seemed to work fine for him so I'd try that first.

It's impossible, I've tried mixing it in ethanol for over in an hour and letting it sit for a day and its still cloudy and doesn't dissolve. DMSO is the only thing that will dissolve it. This correlates with the literature I found online.

Over 5 days so far doing 150mg a day in 2ml DMSO mixed with 8ml of enthanol. No sides so far and shedding has seemed to go down a lot from what I can see. I am doing oral minoxidil so its hard to tell if the shedding is from that or Androgenetic Alopecia. Hardly any itch.

 

[whatevr]

It's impossible, I've tried mixing it in ethanol for over in an hour and letting it sit for a day and its still cloudy and doesn't dissolve. DMSO is the only thing that will dissolve it. This correlates with the literature I found online.

Over 5 days so far doing 150mg a day in 2ml DMSO mixed with 8ml of enthanol. No sides so far and shedding has seemed to go down a lot from what I can see. I am doing oral minoxidil so its hard to tell if the shedding is from that or Androgenetic Alopecia. Hardly any itch.

OK cool I guess. Keep us posted please, this is big.

 

[Grasshüpfer]

Man, I'm getting curious, too. Any sources in Europe?

 

[Bklyn_23]

Very, very interested in hearing of any side effects you encounter Kawnshawn. And of course the results as far as your hair goes.

 

[kawnshawn]

Man, I'm getting curious, too. Any sources in Europe?

You're not gonna find it in Europe. Best bet is Alibaba and getting it tested.

 

[whatevr]

I received my Enza last week.
Mixed it in the standard vehicle, being 70% ethanol and 30% peg.
Started at 1%, doing it 1x a week.
The bottle I'm using is a minoxidil bottle, which is made from white plastic.
The annoying thing is that I can't check if it completely dissolved or not..
So thank you kawnshawn for the update.
I'll test if mine dissolves or not...
Will try to get it lab tested as well.

Thanks for letting us know.

We have two guys on this so far, with different solvents and dosing. Would be cool to keep track of how you both progress so we can determine what works safer and/or better.

 

[kawnshawn]

I received my Enza last week.
Mixed it in the standard vehicle, being 70% ethanol and 30% peg.
Started at 1%, doing it 1x a week.
The bottle I'm using is a minoxidil bottle, which is made from white plastic.
The annoying thing is that I can't check if it completely dissolved or not..
So thank you kawnshawn for the update.
I'll test if mine dissolves or not...
Will try to get it lab tested as well.

Yeah, mix it in a clear glass to see if it dissolves, if it does dissolve in ethanol and peg then you don't have enzalutamide.

 

[DavidsDome]

came across this data sheet:
http://www.eurodiagnostico.com/media/pdf/MDV3100 (Enzalutamide).pdf

Solubility (25°C):
DMSO 93 mg/mL
Water <1 mg/mL
Ethanol 3 mg/mL


and this patent file:
http://www.google.com/patents/WO2014043208A1?cl=en

For intravenous dosing, enzalutamide was dissolved in 50%> polyethyleneglycol-400/20%) ethanol (200 proof)/30%> sterile water for injection (USP), and was dosed via tail vein.

 

[whatevr]

came across this data sheet:
http://www.eurodiagnostico.com/media/pdf/MDV3100 (Enzalutamide).pdf

Solubility (25°C):
DMSO 93 mg/mL
Water <1 mg/mL
Ethanol 3 mg/mL


and this patent file:
http://www.google.com/patents/WO2014043208A1?cl=en

For intravenous dosing, enzalutamide was dissolved in 50%> polyethyleneglycol-400/20%) ethanol (200 proof)/30%> sterile water for injection (USP), and was dosed via tail vein.

Are you using PEG (Polyethylene glycol) or PG (propylene glycol) ???

Important difference.

 

[Sanchez1234]

@JLF you already begun? Goodluck!!

 

[whatevr]

well seen whatevr
they are also talking about intravenous dosing
anyway, I only posted it as extra information and to show that there could be a possibility that it dissolves in ethanol, though very bad
clearly it dissolves much better in DMSO

I already began using it Sanchez
Mixed in ethanol and PG (propylene glycol)
But it seems to be a bad vehicle...

When you make your next batch, use a glass container for mixing, and try to dissolve it in PROPYLENE GLYCOL (PG) first before adding ethanol. If it fails to dissolve, we can cross out PG as a solvent.

POLYETHYLENE GLYCOL (PEG) sounds like it should work as a solvent and it should be a good thing for topical use as well. This data means a lot to us because we are operating on low info, so whatever information you guys can contribute so we can find the optimal vehicle and mixture is much appreciated. Thanks!!

 

[DavidsDome]

some more data sheets

https://www.cellagentech.com/content/product_files/MDV3100_(Enzalutamide)_Product_specification.pdf

http://www.apexbt.com/downloader/document/A3003/Datasheet.pdf
The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.

 

[Kevand]

He only used it 3xW, assumedly this has strong effect through suppression of AR geneexpression or it acts systemically. I doubt the effect comes from only local blocking AR, since I dont think the effect can be sustained 2 days without going systemic.
I wonder if longer half-life in anti-androgen means longer blockage of the receptor independt the drugconcentration at receptor site. What are the factors for how long time a drug block a receptor? I guess affinity and ofc receptor at concentration site, but anyone that can explain this further?