Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical

[ALightInTheDark]

So with all testers, how many failed at Enza topically, how many maintain and how many succed to grow something?

 

[DavidsDome]

Just did my yearly blood check.
PSA and testosterone levels were both within the normal range.

 

[FCKW36]

Wow, I think there are some penetration problems with Enza. The vehicle is bs.

 

[whatevr]

Trust me, there are no penetration problems with DMSO.
I got side effects from DMSO+PEG, but maybe some people have issues with that vehicle.
One thing I can say is that it dries VERY slowly. It is possible that the PEG portion does not absorb at all.
I had it on my head for 12+ hours and my head was still shimmering in the morning. I've never seen that with any kind of common mix like Eth + PG.

PEG= polyethylene glycol
PG = propylene glycol
Just to clarify

 

[whatevr]

I'm going off the top of my head but the only people that have failed that I know of is me. A few guys quit because of sides. And maybe around 5 have claimed that its stop/reduced shedding and has caused some vellus hairs

I hope you won't do Darolutamide orally, by the way. No matter what, don't do that.
It won't be very cost-effective either.

 

[kawnshawn]

I hope you won't do Darolutamide orally, by the way. No matter what, don't do that.
It won't be very cost-effective either.

Naw I'm not. It wouldn't be cost effective to do it orally. Would need a lot more than I could afford. Will do it topically.

 

[Aethas]

Maybe add some taurine!?

 

[Aethas]

Thanks for the advice.
Not sure if that will really have a significant effect to be honest.
I ordered some Lithium Chloride to add to the wounding.
Wnt seems to be quite important, although LiCh is probably not the best compound to tackle it with...

Well from feedback and forum from all over the internet! The only supplement that people tell that work is actualy taurine ahah


And by the way if you guys responde good to Licl ill buy some to!! But i want you to check this? Another thing we could add before the wound session(so it penetrate the skin) or after
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093112/

https://www.hindawi.com/journals/tswj/2014/878162/

And this farm actualy sell the same thing they used and they sell you freeze so it stay good
https://www.antlerfarms.com/
if you try to check on internet people say its a scam for the increase in sport performance, it doesnt help your muscle, but study say its good for arthrite and knee and for the skeletic composition and heart, so logicaly should be good for hair. And if you try to check deeper theres some people saying they get back their hair while taking this but they dont know if its placebo effect! Tricky ahah and i cant find people in hair loss forum talking about this more in dept :/

 

[hemingway_the_mercenary]

With the half-life being 8 freaking days you'd have to be crazy to even use it more than 3x a week, even that is probably too much.
Xandrus used it 6 times a MONTH and regained two norwoods. Stuff is crazy powerful and should be used very sparingly.
If I don't manage to get to NW1 with RU I will probably get some of this stuff, get to NW1 and then maintain with RU.

I wish people would have just given up on RU. For all we know it does even bind to the AR strongly. There are other alternatives with much more research data that are shown to bind to the AR very strongly.

I myself have tried Flutamide and spironolactone. In the very beginning I was trying RU but it did nothing for me so I stopped. I think Spironolactone is too weak and RU is too unknown. Very good alternatives would be Flutamide and Bicalutamide. Bicalutamide has a safer side effect profile but I've searched everywhere even the devil's a**h** for this stuff and can't get it. Its genuinely getting to the poin where Im considering moving to a country where its not illegal to buy drugs to try it.

 

[itchymadscalp]

Bicalutamide is weaker than DHT ... and can lead to overexpression of androgen receptors. Be careful. I did that mistake, I tried Bicalutamide ... now I'm losing hair and there is nothing I can do ... nothing works anymore.

 

[hemingway_the_mercenary]

Bicalutamide is weaker than DHT ... and can lead to overexpression of androgen receptors. Be careful. I did that mistake, I tried Bicalutamide ... now I'm losing hair and there is nothing I can do ... nothing works anymore.

lol what are you talking about. Bicalutamide is significantly stronger binding affinity to the AR than DHT and it doesnt lead to overexpression of androgen receptors. You probably got something else


EDIT: reading this a year later is just embarrassing

 

[itchymadscalp]

lol what are you talking about. Bicalutamide is significantly stronger binding affinity to the AR than DHT and it doesnt lead to overexpression of androgen receptors. You probably got something else

https://www.ncbi.nlm.nih.gov/pubmed/20058237
"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity."

If you really want Bicalutamide to work effectively against DHT you have to take high dose (50-100-150). But it won't work in a long term use. That's all.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981508

"bicalutamide has relatively low affinity for AR (at least 30-fold reduced relative to the natural ligand dihydrotestosterone (DHT))"

You don't want to believe me ? Ok ... I don't mind : your life, your mistakes. I just wanted to warn you, you do whatever you want

 

[hemingway_the_mercenary]

https://www.ncbi.nlm.nih.gov/pubmed/20058237
"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity."

If you really want Bicalutamide to work effectively against DHT you have to take high dose (50-100-150). But it won't work in a long term use. That's all.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981508

"bicalutamide has relatively low affinity for AR (at least 30-fold reduced relative to the natural ligand dihydrotestosterone (DHT))"

You don't want to believe me ? Ok ... I don't mind : your life, your mistakes. I just wanted to warn you, you do whatever you want

wow, looks like you were right. thanks for sharing, I thought I had seen that bicalutamide has a much stronger binding affinity than DHT but looks like I must have misread idk

isnt the hypersensitivity issue for prostate cancer cells only, that would make sense me. Otherwise that would be very worrying and could be a possible side effect from all other non steroidal anti androgens (which would mean we are fucked).

are there any other sources that talk about Bicalutamide androgen receptor affinity?

 

[hemingway_the_mercenary]

I also found this. Its very unclear if the restance is due to Bicalutamide itself on any cell with an AR or only to prostate cancer cells

Niclosamide and Bicalutamide Combination Treatment Overcomes Enzalutamide- and Bicalutamide-Resistant Prostate Cancer.
https://www.ncbi.nlm.nih.gov/pubmed/28500234

edit:

@itchymadscalp upon further research I found that even spirinolactone has a stornger AR affinity than flutamide but the high levels of flutamide molecules circulating compensate for this and make it much stronger than spironolactone. Otherwise, it would have almost no effect on your body as DHT is almost 10x as strong as testosterone which would mean that bicalutamide could not even out-compete testosterone making completely useless
obviously this is not the case

 

[DavidsDome]

https://www.ncbi.nlm.nih.gov/pubmed/20058237
"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity."

hmm that is worrying...

 

[sito]

https://www.ncbi.nlm.nih.gov/pubmed/20058237
"Prolonged treatment with bicalutamide induces androgen receptor overexpression and androgen hypersensitivity."

If you really want Bicalutamide to work effectively against DHT you have to take high dose (50-100-150). But it won't work in a long term use. That's all.

If that's the case then probably the same applies to ru since they are similar. In 2012 when I first added RU as a treatment I had great results, even regrowth without any (noticable) sides. But after a year I started loosing again ground, and it felt like it isn't working anymore.

Maybe a cycle would counteract an AR overexpression, but with broscience we won't be able to find a good cycle regimen (if even any exist). There is a lack of studies on this matter

 

[hemingway_the_mercenary]

hmm that is worrying...

i think this was on specific anti-androgen resistant cancer cell lines

most of the research on anti-androgens is for prostate cancer. Usually, receptors should downregulate without the presence of androgens

 

[hemingway_the_mercenary]

I ran out of Enza.
Been doing it for around 9 months now.
Switched from finasteride + RU to dutasteride + Enza.
Although there have been new vellus hairs over my temple, basically none of the already existing vellus hairs went terminal.
I'm not planning on buying a new batch of Enza.
I've got some PGE2 and ordered Valproate Sodium.
Let's see if these substances can boost some regrowth.
I'll still be using dutasteride to keep DHT under control.
Might be adding Seti as well.
Not sure if someone is still on Enza, if so all the best to you guys.
I can at least say that 45mg/daily, in DMSO/ethanol/PEG400, didn't give me any sides.

i recently got a batch a bicalutamide (finally!) so I will be preparing a solution soon to see how it works. I noticed sides from just spironolactone so if even with enza you had no sides at all maybe it didnt reach the hair follicle

 

[DHTcel]

Tried out enzalutamide, not really any beneficial effects on my hair. However, I did get puffy nipples from it.

 

[el_duterino]

Tried out enzalutamide, not really any beneficial effects on my hair. However, I did get puffy nipples from it.

of course, you have zero hairloss and perfect thick hair based on your pics, even the most powerful anti androgen in the world is not going to have any effect for you. ..