Kevand
Established Member
- Reaction score
- 46
Mdv3100 (enzalutamide) - Superstrong Antiandrogen Topical
- Thread starter whatevr
- Start date
- Reaction score
- 3,656
With DMSO he said the solubility will go way down when we add ethanol and water and what not, but based on my calculations it should not be an issue, even if we use up to 30% DMSO in the mix (which should be more than enough) it will still be better than just making the whole vehicle out of DMSO.
And about PEG-400 he didn't really say anything particular, which is what bothers me the most.
It's clear that it can dissolve MDV, based on that rat patent, so that shouldn't be the problem - perhaps he thinks it won't penetrate topically?
I have no idea, he's always so vague it makes all this back-and-forth frustrating.
Not that I've noticed. Still can grow my beard easily and skin hasn't changed.
Kevand
Established Member
- Reaction score
- 46
Not much has changed. If I comb my hair like every 3 days I'll shed like 15 hairs and 11-12 of them are vellus. Way better than the 30-40 I shed just from showering once a day that had tons of terminal hairs. Have been getting lazy and only been doing it every 2-3 days though. Hair does feel better and looks nicer but that's just my optimism
I guess if we consider Xandrus 5month time line back to full recovery most of the guys trialing this are only about 1/5 of the way so its early days yet certainly by the 3rd month of trialling MDV3100 id expect to se some drastic advances if Xadrus claims were legit. Thanks to the guys testing this out!!
FCKW36
Experienced Member
- Reaction score
- 622
@kawnshawn
Thank you very much.
@Recon_s
Of course you can't expect regrowth or something in such a short period of time. The main reason I was asking for is because I wanted to know if shedding is still reduced in if there are sides.
Thank you very much.
@Recon_s
Of course you can't expect regrowth or something in such a short period of time. The main reason I was asking for is because I wanted to know if shedding is still reduced in if there are sides.
@kawnshawn
Thank you very much.
@Recon_s
Of course you can't expect regrowth or something in such a short period of time. The main reason I was asking for is because I wanted to know if shedding is still reduced in if there are sides.
I was just thinking out loud this wasn't a direct reply to your comment...I was going to ask the same question anyway about sides or reduced or increased shedding..
FCKW36
Experienced Member
- Reaction score
- 622
No offence, pls don't get me wrong. I only tried to say that we don't need to be disappointed because they are using MDV for such a short period of time.
constantshed
New Member
- Reaction score
- 1
Hi guys,
I saw this thread some days ago and I'm willing to try MDV3100 it out. So I registered myself on Alibaba (first time) and I searched the Enzalutamide from the supplier Shanghai Synchem because you guys said it was legit.
I asked for 10 grams and they replied me the cost will be 350USD.
What do you think of that price ?
Also, I didn't know Alibaba, but that interface for payement does not inspire much confidence :/
I saw this thread some days ago and I'm willing to try MDV3100 it out. So I registered myself on Alibaba (first time) and I searched the Enzalutamide from the supplier Shanghai Synchem because you guys said it was legit.
I asked for 10 grams and they replied me the cost will be 350USD.
What do you think of that price ?
Also, I didn't know Alibaba, but that interface for payement does not inspire much confidence :/
- Reaction score
- 3,656
Nope.
"The active metabolite N-desmethyl enzalutamide is equipotent to the parent compound in vitro, and is present in plasma at the same concentration level as enzalutamide, which may add to the antitumor activity of enzalutamide in patients treated with this drug [13]."
"As confirmed in a drug interaction study, in vitro studies indicated that enzalutamide is mainly metabolized by CYP2C8, with minor CYP3A4/5 involvement [32]. In a 14C-enzalutamide mass balance study, a total of seven metabolites were identified [13]. The two main metabolites in circulation are the active N-desmethyl enzalutamide (M2), which in vitro is equally active as enzalutamide, and the inactive carboxylic acid metabolite (M1) (Fig. 2) [15, 20]"
(Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069300/)
The N-desmethyl oral metabolite also has a longer half-life than enzalutamide (7.8 vs 5.8 days), which is not something that we want. So by using enzalutamide topically, the drug overall has a shorter half-life than when used orally.
(Source: https://link.springer.com/article/10.1007/s40262-016-0403-6, Table 1)
infinitepain
Experienced Member
- Reaction score
- 357
Can you explain how to prepare the RU?
Premade solutions are sh*t, you need the powder, my brain is just damaged to make the calculations to mix it
I dont kow if i should use minoxidil or something else as vehicle
https://www.baldtruthtaIk.com/threads/12391-Complete-RU58841-Usage-Guide
infinitepain
Experienced Member
- Reaction score
- 357
What do you think about RU powder mixed with RU vs ethanol or something else?
Also did anyone here prove hairline regrowth with the RU? also did anyone beat scalp itch with it?
infinitepain
Experienced Member
- Reaction score
- 357
Also, is Anageninc and Kane the same thing?
- Reaction score
- 313