Merck lists "DEPRESSION" as possible Propecia side effect

[HT55]

Have you ever stopped for a minute and thought that maybe all of this research you do finding out POSSIBLE ways Propecia can have bad efffects on the human body is part of the reason you have these side effects ?


I mean all you do is research this drug looking at it's POSSIBLE harmfull effects, filling your brain up with thoughts of how bad this drug is for you.


Hair loss causes depression plain and simple

Hmmmm, you dont think people got these side effects and THEN Started researching? is that not more logical?

Not when guys come on here afraid of taking finasteride because of all the possible side effects, they have never touched the drug and know all about the possible sides.

When it comes to this guy Mew he has been researching finasteride side effects for about 8 years nonstop and has websited devoted to Propeci side effect.I only suggested if he gives it a break maybe he will feel better as the brain is a very powerful thing and if you fill it up with thoughs of all these sides I don't think that can help you get better

 

[Mew]

I only suggested if he gives it a break maybe he will feel better as the brain is a very powerful thing and if you fill it up with thoughs of all these sides I don't think that can help you get better

Ridiculous comment.

Physical changes to one's body (gyno, decreased ejaculate volume/force, complete loss of morning/spontaneous/nocturnal erections, genital shrinkage, muscle atrophy, muscle fasciculations (twitches) and feminine fat deposits) are NOT in one's head.

Get a grip and stop trying to deny the damage that Finasteride can cause, especially long term. You want proof this condition exists?

Here you go, just published in December 2010:

Adverse Side Effects of 5?-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients.

http://www.ncbi.nlm.nih.gov/pubmed/21176115


Your are really kidding yourself if you still think persistent side effects of Finasteride aren't real. Good luck burying your head in the sand.

 

[HT55]

He'll probably be back in a year asking about how to recover.

I've witnessed it time and time again.

Really so after 15 YEARS on Propecia NEXT YEAR will be the year it finally hits me, lol


Want to bet ?

 

[HT55]

I only suggested if he gives it a break maybe he will feel better as the brain is a very powerful thing and if you fill it up with thoughs of all these sides I don't think that can help you get better

Ridiculous comment.

Physical changes to one's body (gyno, decreased ejaculate volume/force, complete loss of morning/spontaneous/nocturnal erections, genital shrinkage, muscle atrophy, muscle fasciculations (twitches) and feminine fat deposits) are NOT in one's head.

Get a grip and stop trying to deny the damage that Finasteride can cause, especially long term. You want proof this condition exists?

Here you go, just published in December 2010:

Adverse Side Effects of 5?-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients.

http://www.ncbi.nlm.nih.gov/pubmed/21176115


Your are really kidding yourself if you still think persistent side effects of Finasteride aren't real. Good luck burying your head in the sand.

I have been on finasteride since 1997 with zero sides, in fact how many guys who don't take finasteride can bench 400 lbs and have sex 3 -4 times a day at age 42 ?

I feel sorry for you but don't PRETEND it happens to everyone

All I made was a suggestion, I never said the sides were not real but you are OBSESSED WITH PROPECIA. Do as you please but obviously what you are doing is not helping you much

 

[Mew]

I have been on finasteride since 1997 with zero sides, in fact how many guys who don't take finasteride can bench 400 lbs and have sex 3 -4 times a day at age 42 ?

Good for you, I'm glad your body is not reacting negatively. Based on your genetics, it seems you are able to tolerate a reduction in DHT/neurosteroids/5AR inhibition better than some.

I feel sorry for you but don't PRETEND it happens to everyone

I never said EVERYONE gets affected. A SUBSET of users get affected.

Re-read the title of that paper again:

Adverse Side Effects of 5?-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients.

you are OBSESSED WITH PROPECIA. Do as you please but obviously what you are doing is not helping you much

Its helping me plenty. Spreading awareness about this problem to shut down claims that persistent side effects don't exist is part of who I am as a result of what this drug did to me. And now, the medical community is starting to publish papers on the condition.

Trust me, I wish I didn't have to sit here spending my time doing this and be out there enjoying life carefree as I once did before Finasteride, but that life was destroyed when I took and then quit this drug, and got stuck with the condition. I'm on a different path now, one I didn't ask to be put on, but I am on it nonetheless - the path of TRUTH about this drug.

Granted, my experience and those of the other SUBSET of men experiencing the problem are likely in the minority... however, being stuck with persistent side effects, no matter how "rare" this problem might be, still deserves to be known that it CAN occur. People need to be properly informed that this condition DOES exist, so they can make a more informed decision when it comes to taking this medication.

Unfortunately there is no test to predict who is susceptible to such adverse reactions, or why they persist in a SUBSET of Finasteride using men. So until that time, its a game of russian roulette based on genetics.

If you feel confident taking that gamble, that's fine. If not, that's fine too. Because all it really boils down to is 50/50.

 

[Ende]

Merck should be forced to do another short study under strict supervision. Give a certain amount of YOUNG men Propecia for a month, and continue only with those who experience sexual side effects. Observe for at least 5 months. What do they have to lose, if everyone returns to normal after discontinuing the drug anyway...

You think it's possible to get this done, Mew? It would put an end to the ignorance, and reveal what's wrong.

 

[Timi]

i had never Depression with finasteride

but with minoxidil
Always tired and worn
Head paralyzed

the Days so emty
minoxidil Stop after one week without minoxidil i feel me good

Timi

 

[Ende]

That's the problem short studies (1-2 yrs) are inadequate, it takes much longer for the full effect of side effects to develop, (and become substancial, in most people, especially PFS cases) they need to do a long term study!

Not in this case. I developed secondary hypogonadism within 4 months. Ask people how long it took before they had severe sexual problems... A 6 months study is more than enough to reveal what's going on.

 

[Ende]

The study would be on men with side effects from Propecia. Maybe some would recover after quitting, but many of them would probably not. The idea is, with a study like this, we would know for sure what's wrong. It would reveal every single step involved in the devastating progress.

 

[HT55]

If you feel confident taking that gamble, that's fine. If not, that's fine too. Because all it really boils down to is 50/50.

Very nice post until the end, NO WAY is it 50/50 , NO WAY !

 

[HT55]

That's the problem short studies (1-2 yrs) are inadequate, it takes much longer for the full effect of side effects to develop, (and become substancial, in most people, especially PFS cases) they need to do a long term study! Otherwise we will just have another repeat of the 1997 propecia trial or whenever that was... The short term FDA trials fall short sometimes(Vioxx, Fen--Phenn, Darvocet, ect) and this is unnaceptable!

http://www.merck.com/product/usa/pi_cir ... cia_pi.pdf

Page 9 of the link that started this thread shows a 4 year controlled clinical study done on over 3000 men taking 5MG a day of proscar




In the PROSCAR Long-Term Efficacy and Safety Study (PLESS), a 4-year controlled clinical study,
3040 patients between the ages of 45 and 78 with symptomatic BPH and an enlarged prostate were
evaluated for safety over a period of 4 years (1524 on PROSCAR 5 mg/day and 1516 on placebo). 3.7%
(57 patients) treated with PROSCAR 5 mg and 2.1% (32 patients) treated with placebo discontinued
therapy as a result of adverse reactions related to sexual function, which are the most frequently reported
adverse reactions.
Table 2 presents the only clinical adverse reactions considered possibly, probably or definitely drug
related by the investigator, for which the incidence on PROSCAR was ?1% and greater than placebo
over the 4 years of the study. In years 2-4 of the study, there was no significant difference between
treatment groups in the incidences of impotence, decreased libido and ejaculation disorder.

 

[Mew]

Very nice post until the end, NO WAY is it 50/50 , NO WAY !

Sure it is.

You either WILL get side effects or you WILL NOT (50/50).

IF you do get side effects, they either WILL resolve or they WILL NOT (50/50).

See how clear that is?


As for the RISK of getting side effects, that's a different story. Merck claims only 2% of men are at risk of developing side effects, however other studies disagree and put this figure much higher.

 

[HT55]

Very nice post until the end, NO WAY is it 50/50 , NO WAY !

Sure it is.

You either WILL get side effects or you WILL NOT (50/50).

IF you do get side effects, they either WILL resolve or they WILL NOT (50/50).

See how clear that is?


As for the RISK of getting side effects, that's a different story. Merck claims only 2% of men are at risk of developing side effects, however other studies disagree and put this figure much higher.

"If you feel confident taking that gamble, that's fine. If not, that's fine too. Because all it really boils down to is 50/50."



That statement can be taken different ways, I took it as your chances of taking Propecia and getting sides are 50% and I have a strange feeling that's how you want people to look at it.

I guess my chances of winning the lottery are also 50/50 if I buy a ticket, either I will win or I won't (50/50)

The chances of my plane crashing next week, either it will or it won't (50/50), etc, etc, etc

As far as me having the genetics to handle finasteride I have to laugh, I was 135 lbs when I graduated form High School and I'm a hard gainer. I have the strength and build I do today because I have been lifting for 20 + years not from any genetics.

 

[HT55]

As for the RISK of getting side effects, that's a different story. Merck claims only 2% of men are at risk of developing side effects, however other studies disagree and put this figure much higher.

I believe said sexual side effects were around 2% not side effects of any kind.

I know you are going to say Merck is lieing but the 2nd paragraph shows more people reporting sides on the sugar pill that Propecia



A small number of men had sexual side effects, with each occurring in less than 2% of men. These include less desire for sex, difficulty in achieving an erection, and a decrease in the amount of semen. These side effects went away in men who stopped taking PROPECIA because of them. In addition, these side effects decreased to 0.3% of men or less by the fifth year of treatment.

In 3 controlled clinical trials for PROPECIA of 12-month duration, 1.4% of patients who took PROPECIA (n=945) were discontinued due to adverse experiences that were considered to be possibly, probably, or definitely drug related. 1.6% of patients who took a sugar pill (placebo; n=934) were discontinued due to adverse experiences.

 

[HT55]

The FDA clinical trials do not always convey the scope of side effects that occur when a vast number of people (More than 3,000!) take the drug for a prolonged periods of time(more than 2 years!)

A few posts back I pointed you to a 4 year trial using 5 times the dosage (5mg)of propecia. So what do you want 50K people in the trial ?

I'm not doubting the effects are real for some but don't take the number 2% and think it's so small. Google any drug and you will see people have TERRIBLE reactions to it, even aspirin

If 1 miilion people have used propecia and 2% got sides well that's 20,000 people who have sides but its still 2%.

Now if even 20% of those 20k start posting on the internet thats 4000 people posting negative side effects and it can seem like the sides occur much more often than they do as people who don't get sides don't come on and say they are fine for the the most part.


This guy Mew probably has 10,000 anti propecia posts himself across the internet, probably more. If you coulnt his website ( he runs propecia side effects it's over 100,000 negative posts easy as he started that website about 7 years ago.

 

[Joe-1991]

HT55 you have came in here talking absolute garbage, everybody knows that Merck have lied about the occurrence of sexual side effects. I honestly can't believe people on these forums still quote the 2% bullshit, anyone who does is likely to be ones of those that are scared because they are on finasteride imo.

 

[HT55]

HT55 you have came in here talking absolute garbage, everybody knows that Merck have lied about the occurrence of sexual side effects. I honestly can't believe people on these forums still quote the 2% bullshit, anyone who does is likely to be ones of those that are scared because they are on finasteride imo.

I have been on 15 years with no sides, Nice that a guy who signed up 3 months ago says I'm talking garbage.

If "EVERYONE KNOWS MERCK LIED" then why can't ONE person PROVE IT ?

 

[HT55]

The FDA clinical trials do not always convey the scope of side effects that occur when a vast number of people (More than 3,000!) take the drug for a prolonged periods of time(more than 2 years!)

A few posts back I pointed you to a 4 year trial using 5 times the dosage (5mg)of propecia. So what do you want 50K people in the trial ?

I'm not doubting the effects are real for some but don't take the number 2% and think it's so small. Google any drug and you will see people have TERRIBLE reactions to it, even aspirin

If 1 miilion people have used propecia and 2% got sides well that's 20,000 people who have sides but its still 2%.

Now if even 20% of those 20k start posting on the internet thats 4000 people posting negative side effects and it can seem like the sides occur much more often than they do as people who don't get sides don't come on and say they are fine for the the most part.


This guy Mew probably has 10,000 anti propecia posts himself across the internet, probably more. If you coulnt his website ( he runs propecia side effects it's over 100,000 negative posts easy as he started that website about 7 years ago.

I used to argue those same exact points to MEW as well, I think he probably still hates me (Joke). But I have had a change of heart.

Aren't you still using .25 mg/day or am I thinking of someone else ?

 

[HT55]

Aren't you still using .25 mg/day or am I thinking of someone else

I'm currently in another self trial with finasteride at .25 with Zinc supplentation, I have been back on it for about 6 days. I wanted to give a reduced dose a shot alongside Zinc to see if the Zinc would prevent sides as some here have suggested.

It's really a last ditch effort out of pure desperation, I really don't want to lose my hair. for the three months that I quit I felt like I was 16 again, While on finasteride I didn't even realise my sex drive had reduced! I quit it due to Non sexual sides. I'm aware and believe in the risks, but I'm at a loss of what else to do. It's not much different than a ciggarette smoker who continues to smoke despite the known risk!

If finasteride reduced my sex drive my fiance would make me take it


Good luck with everything

 

[mann02]

How long do I need to take 50mg of zinc????I've read on google that it's only recommended to take it for two weeks then go down to lower dose like 15mg to 22??what do you guys think???