michael barry
Senior Member
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I have washed one wrist in nizoral about every third day (sometimes every other day) for roughly three months now. In the past, I found that revivogen and pine oil could reduce body hair at an application site, while crinagen was fairly ineffective.
http://www.androgeneticalopecia.com/hai ... shampoo-pa ttern-baldness.shtml
The article above lists the many ways that ketoconazole is thought to help hairloss. Intenally, due to its inhibition of one particular chromosome, it strongly inhihibits androgen production in the testes and adrenal gland. However, Ketoconazole also inhibits severeal inflammatory pathways and kills a particular microbial in sebum, malezzia furfur, that might play a role in the immune response in baldness. We know it reduces sebaceous gland size with as little as 2 shampoos a week, and we also know that ketoconazole is found in theraputic concentration in the dermis for up to 72 hours after application (3 days).
My results are.................it seems to be a mild STIMULANT of my wrist hair. The hairs are a little thicker and coarser than they were. In other words, nizoral's trichotic effect (hair growing) overpowers its mild topical anti-androgenic effect.
Do I believe in using it a couple of days a week? You bet............its good stuff. We know for a fact that at least at the sebaceous gland level of the dermis (higher up then the dermal papilla) its anti-androgenic......althought not super-powerfully so.
Using nizoral 1% 2-3 times a week has been found to be about as effective as appling 2% minoxidil one time a day, or perhaps using "1%" minoxidil if you will. I think she helps............
Now, my nosy *** is testing apple juice on the other wrist, mixed with a little alchohol. I know that the proanthocyandin oligomers that were tested in the Japanese studies were extracted from commercially available apple juice, so I reason I can use quantity over quality and just generously apply it to see if it has a hypertrichotic effect. Im hoping that as an inhibitor of PKC, TGF beta 1 and TGF beta 2, it will be.
We know that onion juice inhibits PKC and that it contains silica----which inhibits IL-1.
If apple proanthocyandins inhibit two of the three negative TGF-beta's (1&2), then TNF-alpha is the only other cytokine that Uno mentions that is left unaccounted for.
Internal inhibition of TNF-alpha is obtained with fish oil, and I do not believe there is any danger in this because Inuit and Eskimo cultures eat a great deal of fish, and dont have any negative reprocussions from it. Im somewhat afraid of using two doses of curcumin a day to inhibit TGF_beta internally perpetually in 24 hour periods (although 12 hours a day should be alright) due to concerns about dementia when this pathway is utterly inhibited for long stretches of time.
We only have FGF5 and thrombospondin left to account for. If my memory serves, I think horsetail or candula, found in tons of old herbal hairloss remedies, counteracts one of this, but I forget which one. I'll have to look it up.
Anyway,..............the nizoral appears to be trichotic on body hair somewhat, which is a good thing, because we know its mildly anti-androgenic. A great additon to any regimine.
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http://www.androgeneticalopecia.com/hai ... shampoo-pa ttern-baldness.shtml
The article above lists the many ways that ketoconazole is thought to help hairloss. Intenally, due to its inhibition of one particular chromosome, it strongly inhihibits androgen production in the testes and adrenal gland. However, Ketoconazole also inhibits severeal inflammatory pathways and kills a particular microbial in sebum, malezzia furfur, that might play a role in the immune response in baldness. We know it reduces sebaceous gland size with as little as 2 shampoos a week, and we also know that ketoconazole is found in theraputic concentration in the dermis for up to 72 hours after application (3 days).
My results are.................it seems to be a mild STIMULANT of my wrist hair. The hairs are a little thicker and coarser than they were. In other words, nizoral's trichotic effect (hair growing) overpowers its mild topical anti-androgenic effect.
Do I believe in using it a couple of days a week? You bet............its good stuff. We know for a fact that at least at the sebaceous gland level of the dermis (higher up then the dermal papilla) its anti-androgenic......althought not super-powerfully so.
Using nizoral 1% 2-3 times a week has been found to be about as effective as appling 2% minoxidil one time a day, or perhaps using "1%" minoxidil if you will. I think she helps............
Now, my nosy *** is testing apple juice on the other wrist, mixed with a little alchohol. I know that the proanthocyandin oligomers that were tested in the Japanese studies were extracted from commercially available apple juice, so I reason I can use quantity over quality and just generously apply it to see if it has a hypertrichotic effect. Im hoping that as an inhibitor of PKC, TGF beta 1 and TGF beta 2, it will be.
We know that onion juice inhibits PKC and that it contains silica----which inhibits IL-1.
If apple proanthocyandins inhibit two of the three negative TGF-beta's (1&2), then TNF-alpha is the only other cytokine that Uno mentions that is left unaccounted for.
Internal inhibition of TNF-alpha is obtained with fish oil, and I do not believe there is any danger in this because Inuit and Eskimo cultures eat a great deal of fish, and dont have any negative reprocussions from it. Im somewhat afraid of using two doses of curcumin a day to inhibit TGF_beta internally perpetually in 24 hour periods (although 12 hours a day should be alright) due to concerns about dementia when this pathway is utterly inhibited for long stretches of time.
We only have FGF5 and thrombospondin left to account for. If my memory serves, I think horsetail or candula, found in tons of old herbal hairloss remedies, counteracts one of this, but I forget which one. I'll have to look it up.
Anyway,..............the nizoral appears to be trichotic on body hair somewhat, which is a good thing, because we know its mildly anti-androgenic. A great additon to any regimine.
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