Hm what kind of side effects usually come with these creams? & are they reversible once you’re off it? I hope it doesn’t affect my beard lolI just started it this week, no side effects so far. It contains two estrogens - estriol and estradiol. Topical estradiol has a half life of about 36 hours and estriol is about half of that. Something you may get results from even if you don't apply it everyday. I'm probably going to use it daily, but if I get sides I'll start spacing it out.