New GB for Proven Treatment: Cyclosporine A

[coco_304]

You can, but you shouldn't.

Why

 

[coco_304]

Side effects

Even on small dose..?
What is recommended dose?

 

[HansMetjen]

I prefer Zyklon B, but I'll go with Cyclosporine A

 

[HansMetjen]

If we get enough orders we can get this for under $200. Be aware it's a dangerous drug, not for human consumption. For research only. CsA is a powerful immunosuppresant, and has some hepa- and renal toxicity. It is proven to be a powerful hair growth promoter. More powerful than minoxidil in those who respond to treatment.

CsA may be a substitute for HMI-115. There was a paper out a few years ago speculating that SFRP1 inhibition was the moa for CsA, however WAY-316606 is a potent SFRP1 inhibitior and has not worked nearly as well as CsA in vivo thus far. It has also been speculated that the mechanism of action for CsA is through suppression of the PRLR.

At the bottom of the post are two studies; one using oral CsA to treat alopecia areata. 6mg/kg/day. In this AA trial full regrowth was observed in 3 months. The other study used 5% CsA once a week on the scalp. Only 2 people responded to treatment while 6 did not. However, the two that responded grew 381.5 new hairs on average in 12 months. Perhaps with more regular dosing the response rate would have been better. CsA is a very large molecule which doesn't easily penetrate the skin. The non-responders probably didn't get any significant absorption. Topical CsA does not work for psoriasis, but it does work when injected into psoriatic lesions. I believe it is through suppression of PRLR that CsA works. We've all seen the HMI-115 results on macaques. I believe CsA if properly delivered could work nearly as well as HMI-115, albeit with a lot more toxicity. There are reports of men with male pattern baldness taking CsA for other conditions and regrowing hair that was lost decades ago. I suspect that daily mesotherapy, or slight dermarolling before daily applications could significantly improve the response rate.



From the Androgenetic Alopecia trial:



From the oral AA trial:



View attachment 180416View attachment 180417
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Rivertown tested a treatment that was comprised of CsA, minoxidil, and their own proprietary drug. Mostly likely 90%+ of the hair growth can be attributed to CsA and minoxidil. Combining CsA and minoxidil with a potent AA would likely be more effective. Here are their results:

View attachment 180423View attachment 180424

There is a new topical formulation for CsA that was shown effective in mice, without systemic exposure.

A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo - Nano Research

Hair loss due to medical conditions, such as alopecia, male pattern baldness, and cancer chemotherapy treatment, has been a common problem for many individuals. Cyclosporin A (CsA), a fungal metabolite, has been reported to be a hair growth modulatory agent and is a potential drug for hair...

link.springer.com

Sci-Hub | Topical cyclosporine in male pattern alopecia. Journal of the American Academy of Dermatology, 22(2), 251–253 | 10.1016/0190-9622(90)70033-e

Sci-Hub | Oral cyclosporine for the treatment of alopecia areata. Journal of the American Academy of Dermatology, 22(2), 242–250 | 10.1016/0190-9622(90)70032-d

Interesting drug. Kevin Mann talked about it. Not sure whether it's worth the risks? Will I maintain the gains with minoxidil and Finasteride? I wouldn't want to take that stuff indefinitely.

 

[Mr. Slap Head]

RU orally inclined?

 

[HansMetjen]

Can CsA long_term use have side effects ¿?

Yes, it can give you AIDS

 

[coco_304]

What about taking it 4 mg a day orally

 

[HansMetjen]

About 95% of people who take it have hypertrichosis. Famous hair researcher Ralf Paus called it the most powerful hypertrichosis promoting drug.

Ah, that's not good. I don't want to become an ape

 

[HansMetjen]

That's why we take it topically

Yeah, hopefully it will avoid systemic effects.

 

[Mr. Slap Head]

Apecels

 

[losingbattle88]

Apecels

Im gonna top you when you become a shemale boi.

 

[coco_304]

That probably wouldn't be enough to grow hair on your head. Why would you take it orally instead of topically?

That's why we take it topically

How mg of it needed.
About topically, dont know its seems more difficult to use topically, dont know how to make it too.

 

[Mr. Slap Head]

Ho

How mg of it need,
About topically, dont know its seems more difficult to use topically , dont know how too make it too.

I drink a bottle of minoxidil every day, it’s a good nightcap tbh

 

[losingbattle88]

I drink a bottle of minoxidil every day, it’s a good nightcap tbh

And it works to bloat you enough to start dating frogs.

 

[HansMetjen]

10mg/ml. There are threads on here which discuss making topicals. Using it topically may not prevent side effects, but it is likely safer than using it orally.

Are we talking mg or µg? Some people confuse them....

 

[resu]

That probably wouldn't be enough to grow hair on your head. Why would you take it orally instead of topically?


That's why we take it topically

Even minoxidil makes my eyelashes long, when blinking they would occasionally get stuck. I'm off minoxidil for 2 years and that doesn't happen anymore, only applied minoxidil 1ml each day on the crown.

Same would happen with this stuff or worse.

 

[Mr. Slap Head]

Even minoxidil makes my eyelashes long, when blinking they would occasionally get stuck. I'm off minoxidil for 2 years and that doesn't happen anymore, only applied minoxidil 1ml each day on the crown.

Same would happen with this stuff or worse.

U bald now, nigga?

 

[NamelessGhoul]

U bald now, nigga?

can i just say, i enjoy your posts

 

[Hairful]

What about taking it 4 mg a day orally

Cyclosporine is used in organ transplants recepients to suppress their immune system from attacking the transplanted organs. This drug is a toxin from some fungi that murders immune system and it’s not a side effect, murdering immune system is it’s main use.

So use your brain and think how this stuff even at low doses might not be a good idea. Hint: Our immune systems protect us from infections

The hope with topical is it doesn’t penetrate below the outer skin layer where hair follicles are and doesn’t get to bloodstream but we don’t know cause it hasn’t been researched for this purpose

 

[coco_304]

Cyclosporine is used in organ transplants recepients to suppress their immune system from attacking the transplanted organs. This drug is a toxin from some fungi that murders immune system and it’s not a side effect, murdering immune system is it’s main use.

So use your brain and think how this stuff even at low doses might not be a good idea. Hint: Our immune systems protect us from infections

The hope with topical is it doesn’t penetrate below the outer skin layer where hair follicles are and doesn’t get to bloodstream but we don’t know cause it hasn’t been researched for this purpose

So i can stay at home and take it for 3 months.
How much to take it for seeing results.