New Studies Show Vit D Implicated In Hair Loss And Calcipotriol

[Afro_Vacancy]

Examine.com on
https://examine.com/supplements/sulforaphane/

The recommended dose appears to be ~20 mg/day, which is higher than I'm finding in supplements.

Who's using this besides @bridgeburn ?

 

[Jk1]

i use kale in my nutribullets also high in sulphorophane and will add circumin to my topical oils i.e castor peppermint and now circumin oil as well...as cod liver oil

 

[bridgeburn]

I found some more information About sulforaphane, There's a problem, the active form appears to degrade. The form that is in broccoli is sulforaphane glucoraphanin, and when coming into contact with the enzyme myrosinase, ( which is also in broccoli but in a different compartment of the same cells), then sulforaphane is produced..
"For example, cutting, chewing, or otherwise disrupting the broccoli plant cells initiates the production of sulforaphane. Compared to the stable glucoraphanin, sulforaphane begins degrading soon after production" ----> https://selfhacked.com/blog/panacea-benefits-broccoli-sprouts-sulforaphane/

Sulforaphane is also sensitive to heat, a little heat helps absorbation but too much heat makes it degrade faster, so to get it most bioavailable, Don't over cook your vegetables!!

The study I mentioned earlier showing positive results with broccoli sprout extract, well, they applied the extract After making it themselves.
Basically, cutting and heating broccoli to make the extract, disturbs the cells and causes the glucoraphanin and myrosinase to make active sulforaphane. And then applying the fresh, homemade extract, but i doubt the results would have been as good if buying broccoli sprout extract from a store or online unless it was produced recently within the last 30 days.

As for topicals, .. this study shows sulforaphane completely degraded after 30 days in a conventional pharmaceutical cream formulation.
Using a polyethylene glycol (PEG) ointment base.
"Stability of sulforaphane for topical formulation" https://www.ncbi.nlm.nih.gov/pubmed/23611476


Even if the sulforaphane in a typical supplement is stable, we'd have to take 50 pills a day to get 20mg..
There is one supplement however, Jarrow Forumulas broccomax which contains 30mg of the stable sulforaphane glucoraphanin, (SGS) and the supplement also contains the enzyme Myrosinase preserved inside, supposedly active sulforaphane will form after you digest it.
8mg per pill,
"BroccoMax has been demonstrated in vitro to yield approximately 8 mg of sulforaphane per DR capsule containing 30 mg of SGS."

 

[Jk1]

i f

I've decided that I will sunburn my scalp sometime this week. haha

i dont think sunburn is a good idea ! i would not be suprised is rare sunbirn exposure causes damage whereas daily sun is needed to activate vit d receptor...which indoor office life makes an insolvable conundrum.

 

[bridgeburn]

i f

i dont think sunburn is a good idea ! i would not be suprised is rare sunbirn exposure causes damage whereas daily sun is needed to activate vit d receptor...which indoor office life makes an insolvable conundrum.

Maybe, I'm definitely not going to make this a regular thing. cause that will eventually lead to long term damage.

I remember when I was a kid, getting a bad sunburn on my back, it was bad enough that i was peeling skin, especially my upper back and right after it healed, alot of hair appeared there. even though I didn't hardly get sun exposure on my back anymore, that hair stayed there forever. Of course, I have alot more male hormones now and alot more body hair all over now So I'm sure that hair on my back would've appeared there eventually without that sunburn.. but it's like that burn "triggered" that hair to appear earlier than it was supposed to..
I only hope it can work the same with the hair on the head.

Here's my logic in the sunburn: I'm thinking about how Swiss Temples used Sunburns from UVB lamps in his regimen. He also used Wounding from Dermapen. The concept of wounding I believe is something like this: the damage causes the body to send stem cells to heal the area and if we are lucky some of those cells "might" turn into hair.
So according to this article, -------> "Perhaps most promising is a team of Japanese researchers who added vitamin D to stem cells in their final phases of growth and successfully coaxed these cells into becoming hair follicles." https://www.theatlantic.com/technol...cience-getting-closer-curing-baldness/323785/

Adding Vitamin D Convinced those cells to become hair instead of skin!

I believe that may explain alot of Swiss's success and he didn't even realize it.. The combination of Damage And Sunlight.. and a sunburn is both damage and sunlight. The damage causing stem cells to go to the area and then Vitamin D convincing them to become hair....

Swiss also took Sulfasalazine to cause a shift from pgd2 production to pge2 production..
One of the side effects of the drug is increased sensitivity to sunlight! There are anedoctal reports of people who take that drug for arthritus getting hair regrowth after sunlight exposure. http://forum.hairsite.com/t/full-hair-regrowth-benoxaprofen-and-sulfasalazine-arthritis-drugs/7687

I have also been taking sulfasalazine for a little over a month, I don't know if that's long enough time to get the synergistic effect with UVB.

 

[Jk1]

Maybe, I'm definitely not going to make this a regular thing. cause that will eventually lead to long term damage.

I remember when I was a kid, getting a bad sunburn on my back, it was bad enough that i was peeling skin, especially my upper back and right after it healed, alot of hair appeared there. even though I didn't hardly get sun exposure on my back anymore, that hair stayed there forever. Of course, I have alot more male hormones now and alot more body hair all over now So I'm sure that hair on my back would've appeared there eventually without that sunburn.. but it's like that burn "triggered" that hair to appear earlier than it was supposed to..
I only hope it can work the same with the hair on the head.

Here's my logic in the sunburn: I'm thinking about how Swiss Temples used Sunburns from UVB lamps in his regimen. He also used Wounding from Dermapen. The concept of wounding I believe is something like this: the damage causes the body to send stem cells to heal the area and if we are lucky some of those cells "might" turn into hair.
So according to this article, -------> "Perhaps most promising is a team of Japanese researchers who added vitamin D to stem cells in their final phases of growth and successfully coaxed these cells into becoming hair follicles." https://www.theatlantic.com/technol...cience-getting-closer-curing-baldness/323785/

Adding Vitamin D Convinced those cells to become hair instead of skin!

I believe that may explain alot of Swiss's success and he didn't even realize it.. The combination of Damage And Sunlight.. and a sunburn is both damage and sunlight. The damage causing stem cells to go to the area and then Vitamin D convincing them to become hair....

Swiss also took Sulfasalazine to cause a shift from pgd2 production to pge2 production..
One of the side effects of the drug is increased sensitivity to sunlight! There are anedoctal reports of people who take that drug for arthritus getting hair regrowth after sunlight exposure. http://forum.hairsite.com/t/full-hair-regrowth-benoxaprofen-and-sulfasalazine-arthritis-drugs/7687

I have also been taking sulfasalazine for a little over a month, I don't know if that's long enough time to get the synergistic effect with UVB.

Interesting approach Bridge burn , maybe it could work ? but a bit risky at first ?

I would think a safer bet is to slowly get more and more sun on your head and let the skin slowly adapt to a high UV environment. SUN exposure is definetly safer then UV lamps.. UV tanking beds are banned now in AUS. As long as u have no hole in the ozone layer where you are ??

If you think about what is the fundamental purpose of hair ? to block Sun exposure and burning of the scalp !
So if you do as you are doing sun burning the scalp. .the natural response of the skin is to grow hair and protect itself from burning ! and inversely what is the natural effect if u get no UV on ur head.. hair to fall our to allow more VIT D absorption.. nature is so logical isn't it


if you are doing the Sun burning as wounding I would think it would be a good idea to following the dermarollieng cream usage, with VIT D and VIT A or instead cod liver to aid wound healing. Also maybe a laser helmet also as they helps wound healing as well.

 

[Jk1]

Some more evidence of VIT D, just saw this study.


Exposure to sunlight releases a compound from the skin that can alleviate symptoms of eczema, research has found.

The molecule, called nitric oxide, works by dampening inflammation, which causes itchy skin associated with the condition.

Scientists say their findings pave the way for new therapies which mimic the effects of the sun's rays and could help patients avoid light therapy, which can have damaging side effects on the skin such as raising cancer risk.

Lead researcher Dr Anne Astier, of the Medical Research Council Centre for Inflammation Research at the University of Edinburgh, said: "Our findings suggest that nitric oxide has powerful anti-inflammatory properties and could offer an alternative drug target for people with eczema."

Tests on healthy volunteers found that exposing a small patch of skin to UV light triggers a release of nitric oxide into the blood stream.

Further studies found the chemical activates specialised immune cells called regulatory T cells, which act to dampen ongoing inflammation.

The University of Edinburgh team found patients with eczema saw the increased number of these cells in their blood following light therapy fitted with disease improvement.

Researchers say their findings could lead to new therapies for the condition, which affects around one in five children and one in 20 adults in the UK.

People with severe forms are often prescribed tanning lamps to help manage their symptoms, but these can cause skin burning, accelerated ageing and increased risk of cancer.

Professor Richard Weller, senior lecturer in Dermatology at the University of Edinburgh, said: "It is clear that the health benefits of sunlight stretch far beyond vitamin D and we are starting to fill in these blank spaces."

The study is published in the Journal of Allergy and Clinical Immunology.



but interesting ling internal VIT D does not stop skin itching !

http://www.express.co.uk/life-style/health/804683/itchy-skin-asthma-allergies-vitamin-d


So frequent SUN ON THE head maybe the only solution

 

[Jk1]

So what we know now is some people have a genetic defect in the VIT D receptors in the scalp ,so they need a lot more sun than normal to get the same growth effect and more inflammation response from the Sun as someone without it.

And now we just learnt that UV B , causes releases of Nitric oxide and down regulates immune response in the skin...


So basically us with this genetic risk, if we also work in an office environment or lack of UV for a long time.. we have many compounding factors that all make sense now... and the only solution is sun the scalp ! now which stupid medical professionals again were saying wearing a hat does not cause male pattern baldness ?

 

[bridgeburn]

Interesting approach Bridge burn , maybe it could work ? but a bit risky at first ?

I would think a safer bet is to slowly get more and more sun on your head and let the skin slowly adapt to a high UV environment. SUN exposure is definetly safer then UV lamps.. UV tanking beds are banned now in AUS. As long as u have no hole in the ozone layer where you are ??

If you think about what is the fundamental purpose of hair ? to block Sun exposure and burning of the scalp !
So if you do as you are doing sun burning the scalp. .the natural response of the skin is to grow hair and protect itself from burning ! and inversely what is the natural effect if u get no UV on ur head.. hair to fall our to allow more VIT D absorption.. nature is so logical isn't it


if you are doing the Sun burning as wounding I would think it would be a good idea to following the dermarollieng cream usage, with VIT D and VIT A or instead cod liver to aid wound healing. Also maybe a laser helmet also as they helps wound healing as well.

I'll give my skin a rest after this, maybe apply some ice. I don't have any money for laser helmet right now!! Hahahahahahaha, I do have Tretinoin, maybe that can help skin?
well, I have been going outside these days during the heat of the day and exposing my temples to sun for 5-10 minutes.

So frequent SUN ON THE head maybe the only solution

either sun exposure or topical estrogen, hahaha


That nitric oxide study controlling inflammation makes me wonder if it can also help the autoimmune version hairloss too, alopecia areata?
I can tell you that in the last month, my scalp hardly ever itches anymore, and I used to have a ton of dandruff, and now none, But I've started experimenting with Many treatments recently.

now which stupid medical professionals again were saying wearing a hat does not cause male pattern baldness ?

I'm so embarrassed to go in public without my hat really kinda sucks that we may have to wear it less!! lol f*** this system
But on that note, Look what I've noticed. I'm gunna upload a picture of my foot, cause i can see a clear line where hair doesn't hair grow where I had often left socks on my feet!!

 

[bridgeburn]

Bridgeburn is gonna sunburn!

Bridgeburn is gunna sunburn on a bridge!

 

[Jk1]

I'll give my skin a rest after this, maybe apply some ice. I don't have any money for laser helmet right now!! Hahahahahahaha, I do have Tretinoin, maybe that can help skin?
well, I have been going outside these days during the heat of the day and exposing my temples to sun for 5-10 minutes.



either sun exposure or topical estrogen, hahaha


That nitric oxide study controlling inflammation makes me wonder if it can also help the autoimmune version hairloss too, alopecia areata?
I can tell you that in the last month, my scalp hardly ever itches anymore, and I used to have a ton of dandruff, and now none, But I've started experimenting with Many treatments recently.





I'm so embarrassed to go in public without my hat really kinda sucks that we may have to wear it less!! lol f*** this system
But on that note, Look what I've noticed. I'm gunna upload a picture of my foot, cause i can see a clear line where hair doesn't hair grow where I had often left socks on my feet!!

Does not surprise me.. remember the hairless underground mole rat ? well the inverse Sun causes hair growth and stops inflammation.. so ditch the HAT during day light hours its vitally needed on the scalp..


The nitric oxide immune response eczema must definitely play a role with male pattern baldness inflammation as well as they mentioned T regs as well.... What I would like to know is how much sun exposure is needed to keep these nitric oxide levels up ?

male pattern baldness itch can change daily so I would not be surprised hence that 5 min a day is not enough and 1-2 hours a day would be ideal to be a normal non hermet. how to achieves that with indoor office lifestyle is the problem.

 

[bridgeburn]

look how the hair suddenly cuts off! I used to leave socks on alot when i was younger. Often sleeping with socks on. It's like the feeling of pressure or something covering it triggered lack of growth??? I don't think socks are tight enough to cause lack of blood flow?

 

[bridgeburn]

Anything to do with uvb light Swiss temples protocol used?

yes, I wrote my theory on that in post #228

Haha^^ now I "picture" you in a deck chair on a bridge!

Yes, exactly! And I'll be sitting there looking as nerdy as I can and with a grumpy frown and staring at the ground.

 

[bridgeburn]

male pattern baldness itch can change daily so I would not be surprised hence that 5 min a day is not enough and 1-2 hours a day would be ideal to be a normal non hermet. how to achieves that with indoor office lifestyle is the problem

1-2 hours would burn me!! I'm very white, and the sun is intense here now, especially in the heat of the day.

 

[Jk1]

1-2 hours would burn me!! I'm very white, and the sun is intense here now, especially in the heat of the day.

Sorry forget to say based on location in the world, here in Melbourne its winter and people who do 1-2 hours a day still have abnormally low VIT D ! their was a recent study done of office workers in Melbourne.

If its summer their or you live closer then 37 degrees from the equator ( Melbourne is right on the border) you will make a lot more vit D in less hours. So 20 to 30 min would be enough in strong summer sun .

If u are very white most likely VIT D deficient and also lack of it on the scalp as well if u wear hats .

To minimise risk of skin cancer, i would use Topical Sulphorpahe to activate the vit D receptor and topical VIT D/calciatrol to make up for the lack of VIT D receptor we most likely have. Then over time as ur skin gets darker due to melanin and VIT D goes up in scalp with SUN the natural skin protection mechanism will take over.

Lupus white skin is linked to Low VIT D and also increased skin cancer.. so to be safe take it easy at the start with sun exposure.

 

[bridgeburn]

Sorry forget to say based on location in the world, here in Melbourne its winter and people who do 1-2 hours a day still have abnormally low VIT D ! their was a recent study done of office workers in Melbourne.

If its summer their or you live closer then 37 degrees from the equator ( Melbourne is right on the border) you will make a lot more vit D in less hours. So 20 to 30 min would be enough in strong summer sun .

If u are very white most likely VIT D deficient and also lack of it on the scalp as well if u wear hats .

To minimise risk of skin cancer, i would use Topical Sulphorpahe to activate the vit D receptor and topical VIT D/calciatrol to make up for the lack of VIT D receptor we most likely have. Then over time as ur skin gets darker due to melanin and VIT D goes up in scalp with SUN the natural skin protection mechanism will take over.

Lupus white skin is linked to Low VIT D and also increased skin cancer.. so to be safe take it easy at the start with sun exposure.

Hey, I've been to Melbourne before! and also I stowed away on the ferry from Tasmania to Melbourne (by hiding in someones camper van) to save money, Hahahahaha!

Anyway, I do go outside sometimes, and when in countryside and not around people that could notice my terrible condition, I don't wear my hat. So, yes I often get more than 5-10 minutes, but I really mean that I go outside and get at least the 5-10 min of direct sunlight a day during the most strong sun time, sitting still with my hair positioned to expose the temples. Not just regular being outside when I'm walking somewhere changing directions, and walking under trees sometimes.

Yes you bring up some good points, I may experiment with those topicals in the future, and I'm thinking maybe definitely more topical VDR activators in the winter will be necessary with maybe even more increased outside time in winter months.

 

[Janekoman12]

So what should we do Can sombody write step by step what to do to try this out

 

[Seuxin]

WAIT WAIT WAIT

You're saying....Vit D can "fake" the body and force body to regenerate Hair instead of Skin.

Vit D ? Are you sur ???

Because the process of Follica is : Skin disruption and fake the body with a topical product in order to regenerate hair instead of skin. It force a Hair follicle neogenesis. But at this stage we DONT'KNOW what is this product.

We can easily do wounding with a derminator...( Yeah, derminator is NOT skin disruption, i know). But i don't think vit D Could fake the body like you said.

So, where did you read vit D can force body to repair and produce hair instead of skin?

Thanks.

 

[abcdefg]

Id love to see a picture of a Norwood 3 that stays indoors almost all the time that suddenly starts going outside everyday for an hour and took vitamin D supplements. It just seems very far fetched to me. There is no way on earth with the amount of men going bald that somehow all of them or most of them lack vitamin D.
If anything its the receptor meaning your back to androgen receptors where we have no way to actually adjust or change them. So its kind of mental masturbation because you cant really fix dysfunctional vitamin D receptors by taking supplements.

 

[bridgeburn]

So what should we do Can sombody write step by step what to do to try this out

Hmmmm, well I think something like this..

1. Take a 5alpha reductase inhibitor to keep Dht from antagonizing VDR.
2. limit wearing a hat, and get direct sun exposure on the scalp.
3. during winter months especially, use topical VDR upregulators like calcipotrol and Laser light therapy, etc.
4. supplements to consider?: cod liver oil, tocotrienals, jarrow's formula sulforaphane, etc.
5. drugs to consider?: Sulfasalazine to increase photosensitivity.
6. Dermarolling before sun exposure to combine wounding with vitamin D ( if that article was correct about VD influences stem cells)

* Pathogens can also decrease VDR, so get yourself tested to make sure you don't have chlamydia.

WAIT WAIT WAIT

You're saying....Vit D can "fake" the body and force body to regenerate Hair instead of Skin.

Vit D ? Are you sur ???

Because the process of Follica is : Skin disruption and fake the body with a topical product in order to regenerate hair instead of skin. It force a Hair follicle neogenesis. But at this stage we DONT'KNOW what is this product.

We can easily do wounding with a derminator...( Yeah, derminator is NOT skin disruption, i know). But i don't think vit D Could fake the body like you said.

So, where did you read vit D can force body to repair and produce hair instead of skin?

Thanks.

That's what this article claims.. https://www.theatlantic.com/technol...cience-getting-closer-curing-baldness/323785/
" most promising is a team of Japanese researchers who added vitamin D to stem cells in their final phases of growth and successfully coaxed these cells into becoming hair follicles."

Don't know for sure if it's true. but if it is, I think it would explain Swiss Temple's results, he used dermarolling and sunburns in his regime.
I've written a theory in more detail on this earlier in the thread.

Is active vitamin D, Follica's secret topical??! maybe, hahaha!

Id love to see a picture of a Norwood 3 that stays indoors almost all the time that suddenly starts going outside everyday for an hour and took vitamin D supplements. It just seems very far fetched to me. There is no way on earth with the amount of men going bald that somehow all of them or most of them lack vitamin D.
If anything its the receptor meaning your back to androgen receptors where we have no way to actually adjust or change them. So its kind of mental masturbation because you cant really fix dysfunctional vitamin D receptors by taking supplements.

It's the vitamin D specifically in the skin that's important and I think that supplementing can actually make things worse for your hair!!

this study says:
"Vitamin D3 or 7-DHC or enzyme p450 inside the skin cells’ and adipose/fat tissue cells’ mitochondria transforms cholesterol through intracellular catalytic production into pregnenolone- the mother of all hormones. Pregnenolone transforms into progesterone or DHEA, plus pregnenolone changes into more vitamin D in a photochemical reaction from sunlight with stimulation of photons of UVB in your skin. Then progesterone transforms into cortisol. And DHEA, a neurosteroid, transforms into aldosterone, estrogen, testosterone, glucocorticoids, mineralocorticoids, and other essential hormones"

Vitamin D3 that is taken in a supplement is not the active form of Vit D, It has to get converted later. but this says to me that VitD3 converts cholesterol into pregnenolone and then that pregnenolone could get converted into progesterone or DHEA, progesterone is a precursor to many many hormones and although has some 5 alpha reductase inhibiting ability, can also get turned into Testosterone and other Androgens later on, DHEA can also get converted into the various hormones listed above which may or may not help your hair. But exposure to sunlight causes the Pregnenolone to get turned into the active Vitamin D that we want. So, if supplementing, definitely get enough sunlight.

DHT might also atagonize the VDR in the scalp, so I doubt a highly adrogenic man would be too successful without some kind of adrogen surpression/ 5ar inhibitor.