New Study: Finasteride Reduces The Response To Both Stressful And Rewarding Stimuli.

[Derelict]

I don't care about winning people over, everyone can take what they want. Only bothers me that people are fooled that fina is completely safe when it is far from it.

And I'm on zix for 2 months now and as you know that is still too early to draw any real conclusions but so far it seems to slow down hairloss.


"buzzwords" okay you stop using "buzz comments" like fear mongering in a thread about a scientific study. Btw, fina is used as part of transgender regimens, that's a fact.

And lol, I'm the one with the agenda? Stop projecting you fool, it's obvious what's happening here. You try to delude and convince yourself that fina is safe, that's the real agenda that's at play here. Why else would you feel the need to comment in a thread about a scientific study that's negative about fina?

If I had an agenda I would spam every thread talking about AA's, I do not, check my post history.

Lol, the cognitive dissonance of these desperate balding fools who see fina/duta as their ultimate salvation is crazy. But please take your hormone treatment pills to save your hair, like I said you will learn in due time...

Did you have any sort of itch in the areas you are balding? if so has the zix helped with that? I don't want to get in to an argument about finasteride, it has been done to death on here.

 

[StevenGerrard]

Did you have any sort of itch in the areas you are balding? if so has the zix helped with that? I don't want to get in to an argument about finasteride, it has been done to death on here.

aren't you on Duta yourself? when did you start? any improvements so far? I'm 36 days in and I feel a big shed is about to come

 

[Derelict]

aren't you on Duta yourself? when did you start? any improvements so far? I'm 36 days in and I feel a big shedding is about to come

I started duta last november, i started oral minoxidil last october, my crown still looks like absolute sh*t when wet but when dry and some careful combing i can hide my baldness. Still nowhere near cured and my results from both dutasteride and oral minoxidil have been a bit underwhelming but i have still improved from where i started, you may be a great responder to dutasteride though so just keep popping that pill every morning and hope for the best.

 

[StevenGerrard]

I started duta last november, i started oral minoxidil last october, my crown still looks like absolute sh*t when wet but when dry and some careful combing i can hide my baldness. Still nowhere near cured and my results from both dutasteride and oral minoxidil have been a bit underwhelming but i have still improved from where i started, you may be a great responder to dutasteride though so just keep popping that pill every morning and hope for the best.

I don't know about that.. like I said before, I let my hair get to such a deplorable state (goddamn DHT corroded my entire scalp) it honestly feels like I'm fighting a battle that I can't win

My only piece of hope at this point is knowing that my dad responded extremely well to Combodart (after 6 months or so) granted he took the medication for other reasons but his hair quadrupled in density + regrew his entire crown.. if only I could experience 70% of that.. sigh

 

[Manochoice]

you're misinterpreting what I said (though I'm sure that you know this)

True! You have been stating that you've had aid s though. For you they might be tolerable or even negligible but others might seem them repulsive. So it's matters what your (one's) point of reference is.

 

[Kambrira159]

Lol another idiot enters the thread. I took 1mg EOD for hairloss in the past.

And how the fck can you overdose on fina retard? Do you know taking 1mg or 5mg+ leads to the same inhibition of DHT?

View attachment 132823

Here we go managed to trigger an LCM.

How about reading the Caserini clinical study and coming back.

Yes according to that study you were overdosing potentially by 4 times.

You dumb dumb mong. Only idiots take 1mg oral pills daily.

 

[Kambrira159]

So all the dermatologists are dumb mongs too then since they all prescribe 1mg for hairloss?

Not all of them but many of them are yes.

In Korea for example they prescribe 0.25mg rather than 1mg as the uninformed mongs do elsewhere.

There have been a decent amount of clinical studies recently to suggest that anyway taking 1mg is overdosing substantially.

 

[INT]

I agree that there is no need to prescribe 1mg BUT like I showed in this thread, the effects on serum DTH level are almost the same when taking 0.25mg and thus risks for side effects are the same.

That is if we assume that the finasteride side effects are only caused by the drop in DHT, which seems unlikely given some of the blood results of PFS sufferers that show normal levels of DHT. I wish it was that simple but unfortunately...

 

[Kambrira159]

I agree that there is no need to prescribe 1mg BUT like I showed in this thread, the effects on serum DTH level are almost the same when taking 0.25mg and thus risks for side effects are the same.

There is a 10-12% difference there in DHT inhibition for 0.25mg but that does drop considerably when taking 0.1mg.

As per the recent papers going topical appears the best route.

 

[INT]

True but it seems to be the most logical conclusion though, having low levels of DHT for a long period of time could trigger epigenetic changes hence people who stopped fina and have pfs with normal DHT levels.

I think that you would be right with that conclusion if you would replace the word 'DHT' with '5 AR'

 

[pegasus2]

"Scalp skin DHT levels declined significantly by 13.0% with placebo and by 14.9%, 61.6%, 56. 5%, 64.1%, and 69.4% with 0.01, 0.05, 0.2, 1, and 5 mg doses of finasteride, respectively. Serum DHT levels declined significantly (P <.001) by 49.5%, 68.6%, 71.4%, and 72.2% in the 0.05, 0.2, 1, and 5 mg finasteride treatment groups, respectively."
https://www.ncbi.nlm.nih.gov/pubmed/10495374

 

[INT]

"Scalp skin DHT levels declined significantly by 13.0% with placebo and by 14.9%, 61.6%, 56. 5%, 64.1%, and 69.4% with 0.01, 0.05, 0.2, 1, and 5 mg doses of finasteride, respectively. Serum DHT levels declined significantly (P <.001) by 49.5%, 68.6%, 71.4%, and 72.2% in the 0.05, 0.2, 1, and 5 mg finasteride treatment groups, respectively."
https://www.ncbi.nlm.nih.gov/pubmed/10495374

Your point is?

 

[Ollie]

Not all of them but many of them are yes.

In Korea for example they prescribe 0.25mg rather than 1mg as the uninformed mongs do elsewhere.

There have been a decent amount of clinical studies recently to suggest that anyway taking 1mg is overdosing substantially.

You and @Pigeon are both wrong about finasteride dosing. Serum DHT change is flat dosage response but tissue concentrations of 5ar (skin, brain etc..) are much more linear.

Cant be bothered to dig the paper out but in order to decrease local 5ar in the actual follicle itself to the same degree that 1mg of finasteride does for the prostate you would need to take 50mg daily. Efficacy of finasteride and hairloss is actually pretty linear.

 

[StevenGerrard]

Lol, the cognitive dissonance of these desperate balding fools who see fina/duta as their ultimate salvation is crazy. But please take your hormone treatment pills to save your hair, like I said you will learn in due time...

I wish irreversible baldness upon you!

 

[StevenGerrard]

I only wish you the best but sadly you will learn the hard way like most.

eh.. I know what I have signed up for. I have told you this before, I get that depleting my body of DHT isn't ideal but I DON'T WANT TO BE BALD. Why can't you comprehend this?

 

[Michael1986]

You and @Pigeon are both wrong about finasteride dosing. Serum DHT change is flat dosage response but tissue concentrations of 5ar (skin, brain etc..) are much more linear.

Cant be bothered to dig the paper out but in order to decrease local 5ar in the actual follicle itself to the same degree that 1mg of finasteride does for the prostate you would need to take 50mg daily. Efficacy of finasteride and hairloss is actually pretty linear.

Have you got a source to back that up? I don't think it is known yet how much 5ar inhibition a 1mg dose of finasteride will achieve within the hair follicles themselves, and whether or not it would be significantly different from that of a much smaller dose such as 0.25mg.

 

[itsjustsimon]

hairloss making your life miserable > this study

 

[Ollie]

Have you got a source to back that up? I don't think it is known yet how much 5ar inhibition a 1mg dose of finasteride will achieve within the hair follicles themselves, and whether or not it would be significantly different from that of a much smaller dose such as 0.25mg.

I'll try and find the source. Im pretty sure i have at least the screenshot of the paper saved on my laptop somewhere. Regarding 1mg vs 0.25mg however i can tell you anecdotally they offer very different efficacy. I originally used 1mg and had full regrowth. Sides hit 7 months later so had to taper down to 0.5mg and started shedding like crazy and losing my hairline, sides still persisted so tapered to 0.25mg where sides subsided but over the course of about 4 months i lost the 1mg gains completely. Back on 1mg now and slowly regrowing whilst managing my E.

 

[Kaue carrera]

Pílulas anticoncepcionais também podem causar trombose. Mas qual é a chance disso?

Se você for ler tudo o que pode acontecer mal, não sairá de casa.

Tome o remédio, mantenha o cabelo e seja feliz. Não se concentre nos negativos, isso não é bom para você.

 

[Kaue carrera]

finasteride should have this and several other side effects.
but how many people will really be hit by it?
what are the placebo or psychological effects
The more you read about the negatives, the worse it will be.

I believe everyone should try.