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even minoxidil? I dont really think so...
New Topical finasteride Study - Efficacy + Sides
- Thread starter Ollie
- Start date
even minoxidil? I dont really think so...
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- 775
Of course. There is a reason it has reported sides too.
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- 1,027
It goes in a small % , anyway, with continuous use of lotions, cause Ethanol and PG, the skin got it more permeable, so that % can increase.
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- 1,027
The think is the % that it goes systemic .
Back in 2002, the combo oral minoxidil plus oral spironolactone was the thing, So, I tried it . Oral Spironolactone is the main drug that cause Gynecomastia, and, Ofcourse , I got it. Real Gyno, not fat . If you think that loose your hair is bad, imagine what is having nipples like a women. So I had to go under surgery. An interesting thing is that they don't remove the whole gland, meaning, if you us it again, it will give you gyno again.
THEN , after the surgery, I started Spironolactone cream, and it didn't gave me gynecomastia, I sill use it .
So, it depend on many things. In general this topical use are safe : minoxidil , azelaic acid, tretinoin , spironolactone, etc
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- 775
Good you got it sorted, but why would you go on ORAL spironolactone in the first place? That's just crazy.
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So where do I get topical finasteride as of 2019 in Europe?
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...solution or liposomal gel?
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- 14
I thought so too. From what I have read, H&W set the standard concentration to 2.5%, asked FP to reduce systemic absorption, and they came up with a liposomal gel. But if liposomes are actually a means to increase penetration, the effect was to improve efficacy, not reduce systemic absorption... Maybe we should try a 0.05% version of the liposomal gel.
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Not op but I'm using 0.05% from minoxmax once a day for 3 weeks with 0 sides. Wouldn't use it twice a day like it says on the bottle
i didnt get sides from 0.1% liposomal over the last months , but didnt get much benefit either, if any.
i had tried the 0.5 % and it was the same as oral
How's the Minoxidilmax 6% + 0,05% (Essengen-6) to apply? I mean the texture, is it greasy? Does it dry fast? It says on the website it has a "reduced" amount of PG (propylene glycol), have you noticed any itchiness? Have you used other minoxidil products you can compare to?
Thanks
I been using topical finesteride for years and I have maintained my hair. First was Dr Lee, Dr Klein and now Susan Murray Avenue Apothecary
check my thread:
https://www.hairlosstalk.com/intera...eck-here-for-alternative.121814/#post-1797859
check my thread:
https://www.hairlosstalk.com/intera...eck-here-for-alternative.121814/#post-1797859
Way less greasy than rogaine, dries pretty quick. Has tons of ethanol in it
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I have been looking into this for the last couple of days. At first I was confused because I read that the Milan version was designed to minimize systemic absorption, and yet they selected a rather high concentration (either 1.0 or 2.5%) and as you stated liposomes even increase penetration... However, eventually I found out that (1) they use liposomes to allow for "delayed delivery over 24 hrs thus limiting systemic absorption" (my translation) and (2) something referred to as silicon particles are also used to keep delivery local. May I ask what you make of this?
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Liposomal gel, I may try again though
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EDIT: If you used 1 ml every day, from what I understand that should roughly correspond to the 200 μL dose in the latest Polichem study, which was considered effective while reducing serum DHT by "only" 25%--as long as the liposomal gel acts in a similar way as HPCH. If that still gives sides one could try reducing the amount or frequency, e.g. every other day (some doctors recommend 3 times per week).
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For everyone's benefit, I'll drop this study here: http://cyber.sci-hub.tw/MTAuMzEwOS8wOTU0NjYzOTcwOTE2MDUxNw==/mazzarella1997.pdf
Same vehicle, (purportedly) no systemic effects, and positive results (though not using the standard metrics).
This was published prior to oral finasteride's FDA approval for hairloss and uses a very low concentration (.005%) applied twice daily (1 ml per application).
Same vehicle, (purportedly) no systemic effects, and positive results (though not using the standard metrics).
This was published prior to oral finasteride's FDA approval for hairloss and uses a very low concentration (.005%) applied twice daily (1 ml per application).