- Reaction score
- 2,721
As do I, but i use a lot of topicals as is. I’d role the dice and take it orally but I’m actuslly immunosuppressed. If you know a decent topical recipe I’d be interested to Maybe give it a go.
Old Kitchen Sink Approach- Dont Just Rely On Seti Alone....
- Thread starter proscar2
- Start date
- Reaction score
- 3,660
Let's see. A bunch of dubious chinese manufacturers produce a drug of questionable quality and composition under the name of Setipiprant for years. A bunch of people try it the wrong way(topically) with completely ineffective vehicles, or try it the right way (orally) but under-dosed by a factor of 10.
One man who actually takes the legit drug the right way at the dosage actually used in the clinical trials maintains his hair on NOTHING but Setipiprant and even sees improvements, despite the fact that lowering PGD2 was expected to produce maintenance at best.
And yet, Seti is garbage and doesn't work. Sometimes I'm amazed by you people.
- Reaction score
- 2,721
You gonna try it mate? I’m wanting to have a crack myself,’but the legit stuff is so exy.
- Reaction score
- 3,660
I'm thinking about it, but topical effectiveness seems to be sh*t and the oral dosing is just insane, price-wise.
- Reaction score
- 42
Has anyone gotten results with low dose oral Seti with Bio-Piperine to improve the absorption?
- Reaction score
- 2,721
Oh yeah I’d only take it orally. I’m not going to risk hundreds on something that works less effectively than just eating the sh*t.
- Reaction score
- 316
Ppl still not getting that biopeperine wont work for Seti? It was well explained by swiss.
- Reaction score
- 223
Sigh. I know there is no way around it but the brain drain that takes place on hair forums is depressing. People make a discovery, figure out that it doesn’t work, and stop posting. New person finds old post about the discovery and the process starts anew.
@HairCook..
i explained back that it WOULD WORK as biopiperine works in a two-fold way one is through gut and the other through the enzyme same as grapefruit, so it would work..... read my thread i explained it at length. it would help if people got facts straight. swiss explained it wouldnt work as it's about the enzyme that breaks down the seti. he explained about options for that......with a warning!
i then explained that bio-piperine also stops enzyme that breaks down seti. i'll repost another rebuttal again.
i explained back that it WOULD WORK as biopiperine works in a two-fold way one is through gut and the other through the enzyme same as grapefruit, so it would work..... read my thread i explained it at length. it would help if people got facts straight. swiss explained it wouldnt work as it's about the enzyme that breaks down the seti. he explained about options for that......with a warning!
i then explained that bio-piperine also stops enzyme that breaks down seti. i'll repost another rebuttal again.
You need to go read it again, he never said it wouldn't work.
- Reaction score
- 316
He clearly said that you would need to affect kidney & liver clearance to affect the 50% loss, which biopeperine does not.
@ hair-cook- please stop repeating what swiss says and show your own evidence please
Black Pepper is a spice commonly used in many areas of the world for flavor. Through its active component Piperine, Black Pepper is able to modify supplement and drug metabolism.
A process in the liver called glucuronidation, which attaches a molecule (glucuronide) to drugs to signal for their urinary excretion, is inhibited with piperine. This process prevents excessive levels of drugs and supplements in the body, but sometimes inhibits all uptake and renders some supplements useless. In the scenario of piperine ingestion, excretion of supplements is hindered and certain drugs and supplements can bypass this regulatory stage (as not all are subject to it).
This is good in some cases, as Piperine is required to give curcumin to the extremities rather than it getting consumed by glucuronidation in the liver. However, in some other cases it can lead to elevated levels of certain drugs in the blood. Again, elevated could be good or bad depending on context; regardless, caution should be taken when approaching this compound.
BIO-PIPERINE
http://nutrientjournal.com/black-pe...sorption-of-nutrients-antioxidant-properties/
Bio-enhancing Ability
It has been shown that piperine can dramatically increase absorption of selenium, vitamin B, vitamin C, coenzyme Q10 [1] and beta-carotene, [2]. Piperine also increases the bioavailability of herbal and conventional drugs such as resveratrol and curcumin [12]. Piperine favorably stimulates the digestive enzymes of pancreas which enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.[3] The results of clinical studies of piperine with drugs indicate that piperine administered orally at a single dose ranging from 20 to 50 mg may significantly increase serum drug levels by reducing the clearance of drugs, from natural or synthetic source.[1] The mechanisms by which piperine increases the absorption may involve increased gastrointestinal blood supply [4], postulated thermogenic properties [5] and the increase in bioenergetic processes [6].
Piperine can also attenuate free radicals and reactive oxygen species and has been shown to protect against oxidative damage in vitro.[7]
Safety and Side Effects
Piperin has been shown to inhibit both human drug-metabolizing enzymes P-glycoprotein and CYP3A4 (possibly others too)[8] which may lead to grapefruit-like effect. Inhibition of these enzymes decreases their ability to break down drugs which in turn increases drug blood levels and which causes worse side effects etc. Therefore, black pepper should not be consumed in combination with any drugs. For example, it was shown that a single administration of 1 g of black pepper more than doubled area under the plasma concentration-time curve and elimination half-life of phenytoin [9].
Piperine can be toxic for the central nervous and reproductive systems at high concentrations [11].
Black Pepper is a spice commonly used in many areas of the world for flavor. Through its active component Piperine, Black Pepper is able to modify supplement and drug metabolism.
A process in the liver called glucuronidation, which attaches a molecule (glucuronide) to drugs to signal for their urinary excretion, is inhibited with piperine. This process prevents excessive levels of drugs and supplements in the body, but sometimes inhibits all uptake and renders some supplements useless. In the scenario of piperine ingestion, excretion of supplements is hindered and certain drugs and supplements can bypass this regulatory stage (as not all are subject to it).
This is good in some cases, as Piperine is required to give curcumin to the extremities rather than it getting consumed by glucuronidation in the liver. However, in some other cases it can lead to elevated levels of certain drugs in the blood. Again, elevated could be good or bad depending on context; regardless, caution should be taken when approaching this compound.
BIO-PIPERINE
http://nutrientjournal.com/black-pe...sorption-of-nutrients-antioxidant-properties/
Bio-enhancing Ability
It has been shown that piperine can dramatically increase absorption of selenium, vitamin B, vitamin C, coenzyme Q10 [1] and beta-carotene, [2]. Piperine also increases the bioavailability of herbal and conventional drugs such as resveratrol and curcumin [12]. Piperine favorably stimulates the digestive enzymes of pancreas which enhances the digestive capacity and significantly reduces the gastrointestinal food transit time.[3] The results of clinical studies of piperine with drugs indicate that piperine administered orally at a single dose ranging from 20 to 50 mg may significantly increase serum drug levels by reducing the clearance of drugs, from natural or synthetic source.[1] The mechanisms by which piperine increases the absorption may involve increased gastrointestinal blood supply [4], postulated thermogenic properties [5] and the increase in bioenergetic processes [6].
Piperine can also attenuate free radicals and reactive oxygen species and has been shown to protect against oxidative damage in vitro.[7]
Safety and Side Effects
Piperin has been shown to inhibit both human drug-metabolizing enzymes P-glycoprotein and CYP3A4 (possibly others too)[8] which may lead to grapefruit-like effect. Inhibition of these enzymes decreases their ability to break down drugs which in turn increases drug blood levels and which causes worse side effects etc. Therefore, black pepper should not be consumed in combination with any drugs. For example, it was shown that a single administration of 1 g of black pepper more than doubled area under the plasma concentration-time curve and elimination half-life of phenytoin [9].
Piperine can be toxic for the central nervous and reproductive systems at high concentrations [11].