OliX-Pharmaceuticals-Announces-Results-from-Preclinical-Study-of-Hair-Loss-Therapeutic-Candidate

[trialAcc]

That sounds really dangerous. Could they prevent transcription of the AR gene locally or would it affect the entire body / systematically?

The whole point of CRISPR is to be as accurate as possible. If it went systematic in any way/shape/form it would never be used in humans for something like hairloss, because the edits are permanent and the repercussions could be vast. That's why the continue to work on as targeted vectors as they possibly can and by the time it's ever used for something like hairloss would be fine-tuned from use in actual life-debilitating situations.

 

[Tom4362]

What is KY? Kintor?

KY19382, a novel activator of Wnt/β-catenin signaling, promotes hair re-growth and hair follicle neogenesis

Background and Purpose: The promotion of hair regeneration and growth heavily depends on the activation of Wnt/β-catenin signaling in the hair follicle including dermal papilla (DP). KY19382, one of the newly synthesized analogs of indirubin-3’-monoxi

www.authorea.com

 

[Throwaway94]

AR is the GOAT target. Since we're trying to compensate for our missing epi-testosterone which acts as both an AR antagonist and a 5-AR inhibitor, degrading AR comes closer to offering the whole-spectrum protection against androgens that our follicles are naturally lacking.

I'm curious as to how that would affect sebaceous gland function. Do we get to keep our gair at the cost of dry itchy scalps and dry bristly hair?

 

[Dimitri001]

It is, SRD5A1 is the gene which encodes for the 5ar-1 protein, same with SRD5A2 and 5ar-2.

In other words, 5ar would not be produced if it silenced those genes?

 

[whatevr]

Yes, although it seems that they're not targeting 5ar during trials despite it being patented. If they can effectively silence the AR then there's no need to.

Silencing both would give better results since no 5-AR would leave more testosterone to be aromatized into estrogen and give more regrowth.

 

[Throwaway94]

Silencing both would give better results since no 5-AR would leave more testosterone to be aromatized into estrogen and give more regrowth.

Would be better to combine with a topical AA to compete with any DHT in circulation wouldn't it? I don't think we can count on 100% inactivation of ARs

 

[whatevr]

Would be better to combine with a topical AA to compete with any DHT in circulation wouldn't it? I don't think we can count on 100% inactivation of ARs

Well I mean, if this stuff does the job it's supposed to, you won't have to. It's supposed to have the advantage of being more effective than current treatments.

But sure, it's not like anyone is gonna forbid you from using this as part of a regimen. We're getting way ahead of ourselves here anyway, this stuff's not coming out for YEARS.

 

[Throwaway94]

Well I mean, if this stuff does the job it's supposed to, you won't have to. It's supposed to have the advantage of being more effective than current treatments.

But sure, it's not like anyone is gonna forbid you from using this as part of a regimen. We're getting way ahead of ourselves here anyway, this stuff's not coming out for YEARS.

Truuueeee the rate I'm going this is all pointless haha I just like speculating.

 

[trialAcc]

This would be phase 1 right or pre-clinical trials?

It looks like stuff is slowly happening for many companies.

I suspect maybe in 5 years we would have decent treatments.

It's going to be phase 1 but more likely a combined phase 1/2. mRNA treatments are not going to be frequently dosed, so they'll probably just test efficacy and safety at the same time based on 1-2 doses.

I wonder if this can still get special treatment from the SK government for early release if it's trialed in the UK.

 

[trialAcc]

I would think that covid helped in the sense that mRNA has been approved and is now known to provide safe results to the world.

I said that before as well, covid mRNA will end up helping the hairloss community.

Probably end up being the cure for people who are going to lose hair in the future, but the jury is still out on whether it will provide any benefit for regrowth.

 

[kuba197]

OliX

www.olixpharma.com

SUWON, South Korea--OliX Pharmaceuticals, Inc. (KOSDAQ: 226950), a leading developer of RNAi therapeutics, announced that the Company has successfully completed a capital raise to support the Company’s R&D activities and improve its financial structure.

The paid-in capital increase totaled KRW 57 billion (approximately USD 45 million) with about 3 million convertible preferred stocks. Eight local institutional investors, including KB Investment, IMM Investment Corp., Company K Partners, Solidus Investment Co., Ltd, Susung Asset Management Co., Ltd., Welcome Asset Management, Focus Asset Management, and Shinhan Capital participated in this third-party capital increase.

The capital will be mainly used to finance the Company’s R&D activities. OliX plans to complete patient administration for its clinical phase 2 hypertrophic scar program (OLX101A) in the US and announce the interim results within this year. The Company’s dry and wet AMD (OLX301A) and androgenic alopecia (OLX104C) programs are also planned to be entered into clinical trials this year, followed by HBV (OLX703A) and nonalcoholic steatohepatitis (OLX702A) in 2023.

 

[RagnarLothbrok]

Well, so we have several siRNA trials moving forward pretty fast on schedule for next >2 years. There might be something to it if so many companies are pushing this angle I guess. Can't wait for some f*****g study to reveal something relevant and not be back-to-back SamuMed bullshit once again.

 

[badnewsbearer]

id hope to see an update on these treatments soon. but I think it might be another disappointment that takes ages to get going. it stated that after they raised 45 million they will enter clinical trials for Androgenetic Alopecia this year. however its almost December and it looks like it will definitely not happen this year. and we are talking phase 1 clinical trials. decade away

 

[badnewsbearer]

new study on this drug published recently

"In ex vivo human hair follicle culture, the proportion of telogen hair decreased, and the mean hair bulb diameter increased in the cp-asiAR-treated group. In isolated primary human DP cells, AR expression was effectively downregulated by cp-asiAR. Furthermore, cp-asiAR attenuated DHT-mediated increases in interleukin-6, transforming growth factor-β1, and dickkopf-1 levels. No significant toxicity was observed in DP cells after cp-asiAR treatment. Cp-asiAR treatment showed effective downregulation of AR expression and prevention of DHT-mediated alterations in the hair cycle and hair diameter, indicating its potential as a novel therapeutic option for Androgenetic Alopecia."

"he stability test performed using low concentrations of RNase showed gradual degrada- tion of cp-asiAR within 16 h (Figure S9). Rapid degradation of cp-asiAR in the plasma would minimize the systemic effect of the treatment. Consistently, pharmacokinetic analysis showed highly enriched cp-asiRNA in the skin for up to seven days but a negligible amount of cp-asiAR in the plasma, liver, and kidney (Table S2)"

https://www.businesswire.com/news/home/20221122005053/en/OliX-Pharmaceuticals-Publishes-Preclinical-Research-Demonstrating-OLX104C’s-Potential-as-an-Effective-Treatment-for-Hair-Loss

"We are glad that, through this publication of our study in Molecular Pharmaceutics, the excellent efficacy of our cp-asiRNA targeting AR on hair loss has been verified by peer reviewers. We plan to submit a Human Research Ethics Application (HREA) for Phase 1 clinical trial near the end of this year, and we expect successful clinical results.”

this is the future I think. this and more targeted delivery of existing drugs is much more promising than cloning which is expensive as f*** and nobody is interested in investing in the trials because tissue engineering is hard and expensive compared to just more strategic delivery of drugs and rna is just in the beginning

additionally this would be once a week dosing, after 7 days lots of the drug is still in the skin and once there isn't it takes another 3 days or so for androgen receptors to regenerate. delivery is still a question but I think like another company in Korea they are looking at nanostructure lipid particles(the carrier topical) or needling(the compound being on the tip of the needle, like tinted micro needling )

 

[badnewsbearer]

now approced for clinical phase 1 trials in australia which the company says will be conducted this year

OliX's hair loss treatment candidate approved for clinical trial in Australia - KED Global

South Korea's OliX Pharmaceuticals has received approval from Australia's Human Research Ethics Committees (HREC) to plan a phase 1 clinical trial of OLX72021,

www.kedglobal.com

if think with siRNA the potential for localized delivery only due to the degeneration of rna in blood is higher than with other topically applied drugs like finasteride or dutasteride.

so this is something to look out for potentially for people with sides from topical anti androgens that still go systemic in part ans accumulate there

this is a siRNA like samiRNA which will come out end of this month (AR mRNA inhibitor which is also patented for SRD5A1 and SRD5A2 genes)

 

[Kagaho]

Degrading or silencing the AR, thats the way to go. Not entirely convinced CosmeRNA is potent enough as a standalone treatment.
Lets hope this approach works better

 

[badnewsbearer]

Degrading or silencing the AR, thats the way to go. Not entirely convinced CosmeRNA is potent enough as a standalone treatment.
Lets hope this approach works better

yes this will do thorough clinical trials. they also patented their approsch for 5 alpha reductase genes all types. i think the critical part is the delivery, if they get this right this could be an effective an very non systemic treatment that targets the AR pathway, finally

 

[Kagaho]

Really good news from OliX:

The Company has determined that it will develop OLX72021 not only as an RNAi technology-based new drug, but also as a cosmeceutical, which offers consumers accessibility and convenience of use. This is based on excellent hair growth effects observed through application to the skin in addition to injection administration recently observed in rodent hair loss models.

If the efficacy of the cosmeceutical version is similar to injection it may be one of the best industry news ever. The results of the clinical trial in Australia can change the game, specially for those suffering sides from systemic drugs.

 

[It_is_over_for_nw7]

Really good news from OliX:



If the efficacy of the cosmeceutical version is similar to injection it may be one of the best industry news ever. The results of the clinical trial in Australia can change the game, specially for those suffering sides from systemic drugs.

If it actually worked, they would aim for FDA approval. If they have to take shortcuts with the cosmecutical route, then it is probably a scam.

 

[Kagaho]

If it actually worked, they would aim for FDA approval. If they have to take shortcuts with the cosmecutical route, then it is probably a scam.

Actually, they are going FDA route for inyections.