Original research theory: How Androgenetic Alopecia is a manifestation of insulin resistance and its connections with CVD & PCOS

[balda]

For example,
there is Rosiglitazone/Thiazolidinedione as a potential preventive/revertive med for fibrosis.
have you heard that anyone tried a mixture with it topically?

 

[feelsbad]

Anyone following these recommendations and seeing a reduction in loss?

 

[thatslin]

Anyone following these recommendations and seeing a reduction in loss?

For me personally, whenever I consume a huge amount of sugar, on a cheat day for example, the shedding would be insane the next day. It happens to me every time. But constraint of sugar or even carbs intake does not do much for hair regrowth

 

[MagicBold]

Be sure Androgenetic Alopecia is always comming with fat/carbons metabolism errors. Obesity, METs, acne, heart disorder - regular satellite.

 

[qerqrqwrqwr]

this thread explains it

basically insulin resistance triggers the "balding but lots of body hair" phenotype

It is male PCOS,

The very short version is:
- androgenetic alopecia really is an early manifestation of insulin resistance, but there are both direct and indirect forms of insulin resistance - which is why it was not found yet
- androgenetic alopecia shares 3 of the 4 different root causes of female PCOS (polycystic ovary syndrome)
- androgenetic alopecia can be halted with dietary and lifestyle changes, but not reversed (I myself achieved a small but visible amount of regrowth in the vertex by following the recommendations covered later in the document, but zero regrowth in the temples. I don't think regrowth can be reliably achieved unfortunately without drugs.)

The document which you can find attached to this post also covers the following topics:
- why androgenetic alopecia is statistically correlated with atherosclerosis and cardiovascular disease and what this has to do with DHT and even shorter lifespans of men compared to women
- why androgenetic alopecia is statistically correlated with prostate hyperplasia and cancer
- how diet causes shiny forehead and oily scalp (sebum) experienced by many balding people
- the role of DHT in microvascular damage (which explains why DHT is not the root cause of balding but still an effective bottleneck to target in order to prevent balding)
- why there is calcification in balding scalps - it really is because of the same mechanisms that cause atherosclerosis
- photos from genetically identical (monozygotic) twins which have balded at very different rates, showing genetic predisposition is only half the story
- a study from China (a country which underwent rapid diet and lifestyle changes in a very short period) showing that only one third of balding Chinese today had a family history of balding, further underlining that genes are only half the story
- how exactly scalp tension (which many consider to be an esoteric hypothesis) plays a role: by pushing the post-inflammatory tissue recovery towards a fibrotic, rather than non-fibrotic, remodeling response

The whole thing is - I believe at least - rather elegant because it manages to combine a lot of conflicting theories and aspects (DHT, scalp tension, calcification, correlations with diabetes/metabolic syndrome) into one explanation that has "use" for all of them.
None of this stuff is new in isolation but I hope the theory can provide a consistent explanation that makes all the puzzle pieces fit together into one coherent view.

Unfortunately the document is quite long (could still be longer but so as not to exaggerate I left out the precise roles of PGD2/PGE2). I hope someone will find it helpful. The document is under a free license so anyone can share it in whichever way they'd like to whomever they'd like and wherever they'd like, if they'd like to. It is my hope that it'll help some people halt their balding progress and keep the hair they still have, even without medication.

If anything is unclear at all or if anyone has critical questions or remarks I'm happy to respond.

Hope someone will find it helpful or interesting - even if only a bit!

These people basically reached the same conclusion

what is causing body hair/nose hair and ear hair if not androgens?

@wester130 increase sodium

bioenergetic.forum

Hyperandrogenism caused by insulin resistance

 

[qerqrqwrqwr]

interestingly, this says metformin raises shbg, which is a drug for insulin resistance

SHBG – A Modulator to be Modulated | ZRT Laboratory

SHBG, or Sex Hormone Binding Globulin, controls testosterone effect in both men and women by modulating changes in sex steroid levels. When SHBG goes up, free testosterone goes down. Since it binds so specifically and tightly to testosterone, it makes up part of the equation that equals androgen...

www.zrtlab.com

"Insulin spikes = hyper insulinemia = low SHBG = hyperandrogenism = excess nose, ear, hair growth."