Dammitletmein,
I want you to take a look at some of these pictures of regrowth. Here is Martin, from the hairlosstalk photogallery. He used "the big three of propecia, nizoral shampoo every three days (leave in for a couple of minutes), and minoxidil
http://hairlosstalk.com/photogallery/pgmartin3.htm
Pretty impressive isn't it? He cut DHT with propecia, he intefered with androgens binding with receptor sites with the keotoconazale shampoo used every third day (keto is detectable 72 hours in the scalp after usage, so its not necessary to use it more), and minoxidil as a growth stimulant that probably interferes with TGF_beta expression, and fights the hardening of collagen fibers in the connective tissue sheath and probably somewhat inhibits the collageneous streamers and their develpoment under the follicle. minoxidil is also a weak prostaglandin analogue, and intereferes with extremely inflammatory prostaglandins like latanaprost does.
Now look at Bryan Shelton's almost two year results with prox-n
alone............[url]http://hairlosstalk.co ... gbryan.htm[/url]
Bryan wasn't using any anti-androgens at all. Prox-n was developed by Peter proctor as a topical that attempted to counteract the immuno attack against the follicle. He uses spin traps and SOD's which attempt to foist inflammatory cytokines from being able to form (he told me that in an email). He puts a stimulant thats a kind of "natural" minoxidil in the product as well as another stimulant, abscorbyl plamitate and another anti-oxidant, BHT.
Dammitletmein,
Roxythromicyn, a immunosuppressant, is in clinical trials for baldness AS A TOPICAL right now. It was somewhat effective on 8 of 12 men who put it on topically in pre-clinical trials. All it basically does in inhibit T-cells from being able to tell the immune system that something is amiss up there on your scalp, its anti-microbial and anti-bacterial, it also inhibits TNF-alpha, one of the inflammatory cytokines. Its in trials, and somebody is paying for those trials, so someone thinks it works and the reasoning behind it.
Scalp biopsies of old, aged, bald scalp reveal that capillaries arent' there in abundance as compared with hirisute scalp at all. Dr. Peter Proctor, inventor of prox-n, wrote that baldness resembles organ rejection through a microscope and that cyclopsorin, an internal immunosuppressant used for organ rejection, is the most effective thing for preventing it and GROWING BACK SOME HAIR........................even more than anti-androgens like finasteride and propecia.
Dammitletmein,
Beleive what you want to about baldness man..............
But I'll tell you this, if you take finasteride, shampoo with nizoral every third day, and use a copper peptide product like either tricomin or prox-N, you should keep what you have up there for a very long while. If you want it to last even longer, add topical spironolactone cream twice a day. There will be a "shed" after one or two months, then your hair will come back stronger and you will keep it. The only other things PROVEN to help are minoxidil and retin-A. I suggest taking curcumin extract (read docj077's posts) and grape seed extract and taking MSM, and getting a good amount of vitamin C also. You might make sure your diet contains silica and a generous amount of the B-complex vitamins. Youd be helping inhibit the inflammatory cytokines shown to be involved with baldness in Dr. Hideo Uno's HISTOPATHOLOGY OF BALDNESS, attempting to counter the immuno attack, blocking androgen receptors, inhbiting five alpha reductase enzymes from making DHT, upping vegf, and getting hair-healthy nutrition to the follicle. Thats about the best you can do at this point. IF you cant afford anything.....................use nizoral every third day.
If Stephen's theory intrigues you, rinse your hair in very cold water after you shower and dont dry it for twenty minutes. You can do this a couple of times a day.
mjd50,
Aderans is supposed to have recruited for its first phase one trial. Intercytex is in the middle of its phase two trial. ICX will probably release info of results around October, because that will have been one year since they shot the guys up with their own cells. There will probably be at least one more "phase 2" trial at ICX before they start the last trial, phase three. ICX claims they think they can hit the market somewhere on this planet (probably somewhere in Europe) by 2010, but I think it will be a year or two later than that, even if this trial goes well. They plan on at least one more phase 2 trial (phase 2B) and probably a third, then phase three, then the application process and 10 month review, then release.
I do think it will come to pass, they grew some hair in phase one and all they were looking for was inflammation (didn't happen). They weren't even trying to grow hair. I think it will be the anwer for baldness we have been waiting for.
Stephen,
Nizoral has been shown to shrink sebaceous glands by 19.-something percent. If they re-enlarged after a year or so OFF Nizoral, would you be intrigued by that?
