Polichem P-3074 Phase 3 Completion In Feb 2018

[FutureSaitama]

Just sharing my experience, i'm on my 5th month of applying h&w topical finasteride gel 0.5%, shedding has almost stopped in it's tracks and scalp inflammation is at minimum, no sides. Previously, i've been using 1/4 proscar and had very low libido and watery sperm. I'm also using minoxidil and alpicort f twice a week.

 

[d3nt3dsh0v3l]

I was told people in this forum are deluded. There is absolutely no way for finasteride to be applied topically on crown and somehow thicken the donor area without going into the bloodstream. The sole reason it works well in certain areas of the scalp and bad on others is because it reduces serum igf1 levels and increases igf1 levels in the skin.

I've been reading several posts of yours and almost everything you post is unapologetically wrong on some level - the worst kind of wrong. The dislikes you get are trying to tell you to go learn a bit more about the topic instead of peddling embarrassingly incorrect information as valuable opinions.

In this particular case, stop saying retarded things like, "people on this forum are deluded" because they disagree with you and go read the literature, because work has already been done with topical finasteride.

Why don't you start with Merck's patent on topical finasteride? Or are those a bunch of deluded idiots coming up with dumb ideas to pay money to protect also?

And hey, here's a novel idea - when you come to the "New Research, Studies, and Technologies" section to make a controvertial claim, rather than insult everyone who disagrees with you, how about you provide citations and supporting documents instead, like everyone else is doing?

That way you won't risk sounding like you really don't know what the f*** you are talking about, kinda like what you're doing now.

 

[Badbald]

Just sharing my experience, i'm on my 5th month of applying h&w topical finasteride gel 0.5%, shedding has almost stopped in it's tracks and scalp inflammation is at minimum, no sides. Previously, i've been using 1/4 proscar and had very low libido and watery sperm. I'm also using minoxidil and alpicort f twice a week.

Thats awsome! how much of it do you apply each day? if you do apply each day that is. Also how long were you taking proscar until you noticed any sides? thanks for the update

 

[PrinceWilliamThe2nd]

Just found this:

So, looks like we have to wait another 0.6-2 years until we can get this, if the FDA eventually approves it. I am wondering if this will be over the counter like minoxidil.

 

[SimonC]

2 years, man, that's so long time. Hope they will make it in 6-8 months.

 

[wc5269]

“A pharmacokinetic phase I study, tested P-3074 b.i.d. [=twice per day] vs oral finasteride 1 mg o.d. [=once per day], revealing a finasteride systemic exposure 15 times lower in the topical formulation.

So compared to 1mg oral, they found a 15x decrease in systematic exposure. Wouldn't that be equivalent to a 0.06mg oral dose? According to this graph that not enough to keep serum DHT inhibition down:

Am I thinking about this correctly?

 

[fuDHTck]

Just found this:

View attachment 83532

So, looks like we have to wait another 0.6-2 years until we can get this, if the FDA eventually approves it. I am wondering if this will be over the counter like minoxidil.

I am not 100% sure about this but I believe it is possible to get it approved faster if you are using substances already approved for other uses.

 

[fuDHTck]

lmao dude calm down.It obviously works if they passed Phase I and II and decided to fun Phase III. But whatever you are smarter.

 

[ZenHead]

Half the members here are frail chucks who feel insulted if you hit them hard with the truth. Just as with every lotion for the past 20 years that did nothing the same applies here. Merck wants to be in control and get their piece of the pie. Simple as that. There is absolutely no way in this life or the next that a topical product will selectively inhibit a potent androgen and not cause the exact same sides. You change the liver’s action by whatever method you take finasteride. It HAS to be in your bloodstream on a 24/7 basis. This isn’t about dosage it’s about the drug staying long enough to start tampering with other hormones and result in hair loss improvement. You people would understand if you actually looked into the drug itself and learned some basics on hormones instead of citing a ton of useless and vague charts about some dudes who got this and that and said such and such. You are absolutely deluded and the same goes for the hair piece community. What’s funny is that you are a balding cuck that spotted my posts immediately and thought you would shut me down. You balding sexless cuck you.

A lot of people use RU without sides. Even though the mechanisms are slightly different, that should be enough to prove that this can work without sides as well.

 

[d3nt3dsh0v3l]

Half the members here are frail chucks who feel insulted if you hit them hard with the truth. Just as with every lotion for the past 20 years that did nothing the same applies here. Merck wants to be in control and get their piece of the pie. Simple as that. There is absolutely no way in this life or the next that a topical product will selectively inhibit a potent androgen and not cause the exact same sides. You change the liver’s action by whatever method you take finasteride. It HAS to be in your bloodstream on a 24/7 basis. This isn’t about dosage it’s about the drug staying long enough to start tampering with other hormones and result in hair loss improvement. You people would understand if you actually looked into the drug itself and learned some basics on hormones instead of citing a ton of useless and vague charts about some dudes who got this and that and said such and such. You are absolutely deluded and the same goes for the hair piece community. What’s funny is that you are a balding cuck that spotted my posts immediately and thought you would shut me down. You balding sexless cuck you.

**citation needed. How are you not getting this?

Exhibit A:

What’s funny is that you are a balding cuck that spotted my posts immediately and thought you would shut me down. You balding sexless cuck you.

You don't know me. Yes sure, why don't you go ahead and tell me about my current hair status and my sexual preferences. I'll believe anything any person on the internet tells me!

Projection:

Half the members here are frail chucks who feel insulted if you hit them hard with the truth.

Sounds like someone I know

I don't have time to entertain your opinions, bro.

Provide sources, or GTFO

All else is bunk, you can add it to a pile of sh*t.

 

[d3nt3dsh0v3l]

99% of “research” here is absolutely hilarious self experiments and vague assumptions, all graciously painted in charts and spammed here.

Citation needed. 99% huh? I'd like to see the statistics

You are a bald cuck.

So are you going to provide proof, or...?

Go to any endocrinologist’s office and grab a few books. Wake up lad.

Excellent suggestion! Unfortunately, the burden of proof fallacy has already been described a few centuries ago. It's YOUR job to provide aforementioned books (Which books? How many is a few? Any endocrinologist's office, you say?) in the appropriate context to buttress YOUR argument.

You want everyone to believe you so badly, right? Topical finasteride is IMPOSSIBLE, right? Well let's see the proof!

This is the last time I will ask you to provide legitimate evidence, preferably in the form of scientific literature. If you fail to comply, I will assume you have nothing and have therefore forfeited the argument.

 

[fuDHTck]

So 2 posts ago you said that Clinical trial phases are a meme and now you are talking about how science works?

Are you f*****g kidding me?

 

[Badbald]

Just found this:

View attachment 83532

So, looks like we have to wait another 0.6-2 years until we can get this, if the FDA eventually approves it. I am wondering if this will be over the counter like minoxidil.

Is this a general timeline you found or is it something you have seen somewhere specifically for this topical finasteride?

 

[PrinceWilliamThe2nd]

Is this a general timeline you found or is it something you have seen somewhere specifically for this topical finasteride?

It's just a general time line for drugs that are seeking approval, not specific for P-3074. Things might be a little faster here, as this is just a reformulation and not an actual new drug Polichem is trying to bring to market here. Though, I personally doubt that we will see this in shelfs before 2019.

 

[Badbald]

Well it wont have to go through the FDA if its not released within the FDAs regions..

 

[d3nt3dsh0v3l]

I will explain.
[...]
And I explain further..

Don't. Are you a doctor? Are you a scientist? Do you have any authority in this field? NO.

In your world disagree = deluded, cuck, idiot, etc.

Asking for actual evidence = retard, need spoon feeding, too many questions, etc.

Do you know what you must do to have any credibility? Cite people who actually know this field, or do the experiments yourself and present them.

Quote experts in the field. Post a study. Show me the page from the book you're so excited about.

Anything you post otherwise is just an opinion.

And your opinion is worth as much as a sack of sh*t.
You don't get to dictate how biology works.

Anyway, I accept your concession of argument.
Thanks for letting me know that you have absolutely nothing backing your claims other than your own brain. The part where you give insults when asked for evidence is pretty striking - please, continue to take pride in your own ignorance and infatuation with your own theories as they seem to be your strongest personality traits (you favor insults too but I think your comebacks are actually quite banal so I won't credit you there).

I look forward to never interacting with you again, knowing full well that you will essentially never produce or allude to anything subject to peer review; it seems you are allergic to the very notion.

That you continue to vehemently ejaculate your baseless claims across this site, not providing any other source than yourself, all the while criticizing this forum for being deluded or otherwise incapable of a productive and scientifically accurate discussion is baffling.

I do hope you leave, and soon.

Edit: @dermrafok You are having an entirely unrelated conversation with me. I do not give a flying f*** about whether or not you think the industry is a "shame" or if the treatments are prehistoric, or whatever. What are you even talking about? I was having a conversation with a person not providing evidence. I'm here for data, not perspective.

 

[dermrafok]

@d3nt3dsh0v3l You will agree that the hair loss industry is a shame not?

 

[dermrafok]

?

@d3nt3dsh0v3l You will agree that the hair loss industry is a shame not?

Why not? Surprise me. Finasteride and Minoxidil: Prehistoric treatments, daily aplication, poor results, side effects...NO MEDICAL ADVANCES IN THIS INDUSTRY. SO...THAT'S A SHAME.

 

[Alternative]

Why does a dented shovel have dog avatar?
Why does the person above look like he is a fan of mouse and watches Tom & Jerry?

 

[paul2222]

I will explain.

Phases are determined by everything except promise. There is funding, competition and money to be made. This is not a run to save your hair. Wake up.

For the retard posting before you did, you clearly see he keeps bombarding me with questions. Reason is he wants to be spoon fed. And he probably doesn’t like when someone ruins his dream.

And I explain further: forget about finasteride and its effects on neurosteroids and realize that Propecia was made as a half measure. Think of it as a drug to transition you from a man to a woman but very slowly. Finasteride has to affect neurosteroids, pituitary, testosterone, estrogen and dht. The goal is to tank your T, raise E, tank DHT, tank serum IGF1, raise skin IGF1 etc. These things grow hair and permanently ruin your sex life, bone density, muscle density, decrease height and result in facial changes. Now the clown here is positive that a topical application of finasteride will selectively block dht in the scalp for 24 hours and in the meantime the constant existence of dht in blood won’t bother to go to his scalp. Not only that, he is absolutely sure that he will maintain and regrow hair with this fine method, because already permanent damage on his scalp from fibrosis and calcification don’t matter. His scalp tension will magically disappear with this topical application, without the need for estrogen to change those tensions by reducing bone mass and relaxing the muscles there. No, he thinks that a spit of finasteride a day makes the baldness go away. The delusion is so ridiculous in every hair loss forum that at this point many cannot be saved. Some good samaritans like me though are here to open your eyes.

It is interesting that the P-3074 formulation is a chitosan that limits systemic absorption of finasteride. In the 100

I will explain.

Phases are determined by everything except promise. There is funding, competition and money to be made. This is not a run to save your hair. Wake up.

For the retard posting before you did, you clearly see he keeps bombarding me with questions. Reason is he wants to be spoon fed. And he probably doesn’t like when someone ruins his dream.

And I explain further: forget about finasteride and its effects on neurosteroids and realize that Propecia was made as a half measure. Think of it as a drug to transition you from a man to a woman but very slowly. Finasteride has to affect neurosteroids, pituitary, testosterone, estrogen and dht. The goal is to tank your T, raise E, tank DHT, tank serum IGF1, raise skin IGF1 etc. These things grow hair and permanently ruin your sex life, bone density, muscle density, decrease height and result in facial changes. Now the clown here is positive that a topical application of finasteride will selectively block dht in the scalp for 24 hours and in the meantime the constant existence of dht in blood won’t bother to go to his scalp. Not only that, he is absolutely sure that he will maintain and regrow hair with this fine method, because already permanent damage on his scalp from fibrosis and calcification don’t matter. His scalp tension will magically disappear with this topical application, without the need for estrogen to change those tensions by reducing bone mass and relaxing the muscles there. No, he thinks that a spit of finasteride a day makes the baldness go away. The delusion is so ridiculous in every hair loss forum that at this point many cannot be saved. Some good samaritans like me though are here to open your eyes.

So, some interesting thigs about P-3074. First, one of the things people seem to be ignoring in the topical finasteride studies are the serum DHT inhibition. If the topical version inhibits Serum DHT that same as oral, then you are still essentially causing some of the same system "damage" as the oral. That said, the system Finasteride in the body is dramatically less when used topically.

The interesting thing about the P-3074 formulation is the vehicle used to carry it (Chitosan). It essentially limits system absorption (not completely). What's more interesting is if you read the study, the LOWEST dose seemed to be the most effective and also systemically only inhibited DHT 25% vs about 70-75% with oral. The scalp DHT inhibition was the same if not better than oral Finasteride last I remember (in the 100μL dose). Also, systemic levels of Finasteride were reduced by a factor of 18-20.

Some of the other formulations of topical Finasteride show a similar DHT inhibitory effect to the oral. This is a no-go ... sure you lower your system finasteride absorption, but you are still affecting DHT systemically.

So, there are more things that people on here may want to pay attention to. Insulin resistance is also a major factor in male pattern baldness. I can't post the studies yet, because I'm a new member, but they show that higher levels of insulin (due to insulin resistance) correlate to higher levels of male pattern baldness. Eating refined sugars, wheat, etc is going to increase your hair loss according to research.

An endocrinologist friend of mine does not want me to be on Propecia (I had an FUE transplant at a very reputable Doctor in NY 4 years ago and the results were amazing). His advice was basically Vit D3 at least 5000/day, 3k Omega 3s, 100 alpha lipoic acid, and on androgel to increase the T a little bit. Low T can also lead to insulin resistance.

That's it for now!

p.s. diet matters