Probiotic Treatment Of Acne And Dandruff Related To male pattern baldness Immune Response

[Armando Jose]

The cause are prostaglandines and leukotrienes,

Is rancid sebum a trigger of microbiota and PGD's?

 

[jamesbooker1975]

Is rancid sebum a trigger of microbiota and PGD's?

I think that Sebum is a result, not a cause.
DHT interact with some receptors, this tigger a cascade that in ultimate state it interact with the CRTh2 that increase the prostaglandin DP2.
This happen in Acne and in Baldness . Higher levels of DHT can start the things sooner ( this is for people under 30s ) .
The 2012 aboud the 2 x times increased levels of prostaglandins in balding males is is the key . The study showing the succes of topical cetirizine is another key of the puzzle and next year we will see the results of the Clinical trial phase 2 of setipiprant.
Following papers and studies since 1998, this is definitive the sooner and closer " cure " path for acne and male pattern baldness .

 

[abcdefg]

yes, I believe T is bad too but a much weaker version of Dht. Androgens and the sensitivity to them is the primary agent of Androgenetic Alopecia. 95% of hairloss is because of genetics telling hair to react badly to male hormones. Pgd2, dkk-1, tgfb, sebumn, inflammation.. it all starts from androgens

Right, but we have to admit everyone is just guessing. We really dont know what causes male pattern baldness before DHT or why DHT triggers these responses. For all we know male pattern baldness originates just from a fluke mutation or malfunction somewhere in the wnt pathway or bone morphogenic protein (BMP) pathways that regulate DP stem cells. Its just not possible to say from what we know.
Hormones are a big difference between men and women. Most women at older ages have very good hair. My grandmas and just a lot of 60 or 70 plus women have teenage hairlines even if a little diffuse thinning. There are way way way more balding men at older ages. It all just lends itself to the credibility of how important androgens are in events leading to male pattern baldness.

 

[deraj]

Right, but we have to admit everyone is just guessing. We really dont know what causes male pattern baldness before DHT or why DHT triggers these responses. For all we know male pattern baldness originates just from a fluke mutation or malfunction somewhere in the wnt pathway or bone morphogenic protein (BMP) pathways that regulate DP stem cells. Its just not possible to say from what we know.
Hormones are a big difference between men and women. Most women at older ages have very good hair. My grandmas and just a lot of 60 or 70 plus women have teenage hairlines even if a little diffuse thinning. There are way way way more balding men at older ages. It all just lends itself to the credibility of how important androgens are in events leading to male pattern baldness.

This isn't necessarily proof its completely androgens to blame. Immune responses and inflammatory reactions are very different between men and women also.

 

[arnoldd]

Women usually have more immune problems than men. Probably estrogens related.
My mother have a lot of allergies..artritis since she was young and have full hair at his 50

 

[kiwipilu]

broscience at its best ^^. The only things I'm sure of: there are numerous kinds of pattern hairloss. some have inflammation(burning sensation), redness, itchy scalp , dermatitis/dandruff bonus, while others don't feel anything and have a perfect looking scalp yet they are thinning...
Some can't maintain 1 single hair follicle with full arsenal and some maintain pretty well with only 1 treatment not even an anti dht but minoxidil or nizoral or... Btw If I'm not mistaken, I remember it was said in an interview that seti (or such drug) won't work for everybody but for people having itchy scalp right?
This shows how complex it is.

 

[UberBaldaten]

Is rancid sebum a trigger of microbiota and PGD's?

P. acnes bacteria live deep within follicles and pores, away from the surface of the skin. In these follicles, P. acnes bacteria use sebum, cellular debris and metabolic byproducts from the surrounding skin tissue as their primary sources of energy and nutrients. Elevated production of sebum by hyperactive sebaceous glands (sebaceous hyperplasia) or blockage of the follicle can cause P. acnes bacteria to grow and multiply.[7]

P. acnes bacteria secrete many proteins, including several digestive enzymes.[8] These enzymes are involved in the digestion of sebum and the acquisition of other nutrients. They can also destabilize the layers of cells that form the walls of the follicle. The cellular damage, metabolic byproducts and bacterial debris produced by the rapid growth of P. acnes in follicles can trigger inflammation.[9] This inflammation can lead to the symptoms associated with some common skin disorders, such as folliculitis and acne vulgaris.[10][11][12]

The damage caused by P. acnes and the associated inflammation make the affected tissue more susceptible to colonization by opportunistic bacteria, such as Staphylococcus aureus. Preliminary research shows healthy pores are only colonized by P. acnes, while unhealthy ones universally include the nonpore-resident Staphylococcus epidermidis, amongst other bacterial contaminants. Whether this is a root causality, just opportunistic and a side effect, or a more complex pathological duality between P. acnes and this particular Staphylococcus species is not known.[13]

 

[Aethas]

So? How do you fix the hair bacteria?

 

[pollutionbrain]

broscience at its best ^^. The only things I'm sure of: there are numerous kinds of pattern hairloss. some have inflammation(burning sensation), redness, itchy scalp , dermatitis/dandruff bonus, while others don't feel anything and have a perfect looking scalp yet they are thinning...
Some can't maintain 1 single hair follicle with full arsenal and some maintain pretty well with only 1 treatment not even an anti dht but minoxidil or nizoral or... Btw If I'm not mistaken, I remember it was said in an interview that seti (or such drug) won't work for everybody but for people having itchy scalp right?
This shows how complex it is.

Yes i believe in this too but there must be some common nominator or else we would not just lose the hairs on our heads.

 

[Afro_Vacancy]

So? How do you fix the hair bacteria?

Reduce sugar consumption, emphasize complex carbs (chia, flax, legumes, etc) and fermented foods (yogurt, kimchi, etc,).