Progress: Regarding The Bicalutamide & Hrt Regimen

[Derelict]

I can totally understand that, i simply didnt expect some people to actually do it. Im also going alot farther with my hairloss battle than most people. Just considering how much money i have spent on it. I'll also experiment with estradiol soon. Nolva is supposed to target estrogen-receptors in breast tissue, which means i should have a lot of E2 floating around in my scalp, protecting and growing my hair, without causing gyno. I can easily combat gyno with nolva when im on steroids, so maybe it'll work with pure estradiol too.

I got really bad gyno at 200mg spironolactone, im going to take letrozole for a month to hopefully reduce it, i don't think it's very good for hair but i can put up with a month of shedding etc as long as it gets rid of my gyno and i can finally weart tshirts and stuff again. Currently 100mg of spironolactone isn't causing any issues wit my chest, no sensitivity etc I'll try that along with duta and 10mg oral minoxidil for another 6 months or so then think about estradiol.

 

[Jacob Williams]

I have never stated that.



Actually, bicalutamide is rarely used within transgender patients. Plus, no judgement on this thread, it’s here to discuss the progress. You should be more concerned with my use of estradiol.



Combine it with a low-dose of CPA, just to off-set the increase in T, which allows you to use smaller doses. I wouldn’t recommend using it alone.



Incorrect, it doesn’t have an effect on the testes, although it does stop sperm production whilst you’re on it as it’s still an anti-androgen.



Recover from what, It’s side effects? In all honesty, you shouldn’t use any anti-androgen if you’re concerned about side effects.

I’m very curious about this low dose cpa + bicalutamide regimen. It seems like I’ve stabilized my hairloss with 100mg bicalutamide + 0.5mg dutasteride, but my gyno is getting really really bad. I’ve had only minor sexual side effects. As I understand what I’m on right now is a potent mix for gyno. Bicalutamide raises my estrogen and my testosterone levels, the dutasteride prevents testosterone from converting to DHT so all the excess is converted to estrogen. I’m nervous about toying with my routine because I’ve yet to find a routine without taking estrogen that actually grows back my hair, so if I lose ground it’s gone forever. At the same time it would be such a burden off my shoulders if I could stabilize my hormones so that I could get gyno surgery without them just growing back. I tried raloxifene but I started after I already have gyno and I gave up on it way too early. It’s hard to tell whether or not your gyno is growing until it’s too late. I’ve been on 200mg spironolactone with 0.5mg dutasteride before and did not get gyno from that, so I’m curious if there’s some sweet spot for me where I can prevent hairloss without growing boobs. I’ve heard that it’s impossible to stay on CPA long term due to crazy sides. This scared me away because I’d like to maintain as much of my masculine features and sexual function as possible, and I’ve heard that CPA has the potential to cause more irreversible changes. I’ve also heard whispers about CPA causing brain tumors. I’d love to have your insight on whether you think I should incorporate CPA and if so what alterations should I make to the rest of my cocktail?

 

[whatevr]

I can totally understand that, i simply didnt expect some people to actually do it. Im also going alot farther with my hairloss battle than most people. Just considering how much money i have spent on it. I'll also experiment with estradiol soon. Nolva is supposed to target estrogen-receptors in breast tissue, which means i should have a lot of E2 floating around in my scalp, protecting and growing my hair, without causing gyno. I can easily combat gyno with nolva when im on steroids, so maybe it'll work with pure estradiol too.

Nolva is going to wreck your hair because it antagonizes estrogen in most places except brain and liver. Use raloxifene, it's even a mild agonist in skin and it's also more effective against gyno.

 

[baba_yaga]

I have never stated that.



Actually, bicalutamide is rarely used within transgender patients. Plus, no judgement on this thread, it’s here to discuss the progress. You should be more concerned with my use of estradiol.



Combine it with a low-dose of CPA, just to off-set the increase in T, which allows you to use smaller doses. I wouldn’t recommend using it alone.



Incorrect, it doesn’t have an effect on the testes, although it does stop sperm production whilst you’re on it as it’s still an anti-androgen.



Recover from what, It’s side effects? In all honesty, you shouldn’t use any anti-androgen if you’re concerned about side effects.

Bica stops sperm production?

 

[Ikarus]

Bica stops sperm production?

Whilst you’re on it, yes.

I’m very curious about this low dose cpa + bicalutamide regimen. It seems like I’ve stabilized my hairloss with 100mg bicalutamide + 0.5mg dutasteride, but my gyno is getting really really bad. I’ve had only minor sexual side effects. As I understand what I’m on right now is a potent mix for gyno. Bicalutamide raises my estrogen and my testosterone levels, the dutasteride prevents testosterone from converting to DHT so all the excess is converted to estrogen. I’m nervous about toying with my routine because I’ve yet to find a routine without taking estrogen that actually grows back my hair, so if I lose ground it’s gone forever. At the same time it would be such a burden off my shoulders if I could stabilize my hormones so that I could get gyno surgery without them just growing back. I tried raloxifene but I started after I already have gyno and I gave up on it way too early. It’s hard to tell whether or not your gyno is growing until it’s too late. I’ve been on 200mg spironolactone with 0.5mg dutasteride before and did not get gyno from that, so I’m curious if there’s some sweet spot for me where I can prevent hairloss without growing boobs. I’ve heard that it’s impossible to stay on CPA long term due to crazy sides. This scared me away because I’d like to maintain as much of my masculine features and sexual function as possible, and I’ve heard that CPA has the potential to cause more irreversible changes. I’ve also heard whispers about CPA causing brain tumors. I’d love to have your insight on whether you think I should incorporate CPA and if so what alterations should I make to the rest of my cocktail?

I think you should add oral minoxidil. I’m using oral minoxidil soon, since my frontal isn’t making the progress I want it to.

 

[baba_yaga]

Whilst you’re on it, yes.



I think you should add oral minoxidil. I’m using oral minoxidil soon, since my frontal isn’t making the progress I want it to.

Thats the first time I know it. Most studies never mentioned anything about bica stopping sperm production, only a decrease. Though you can stop it if you're trying to conceive then get on it.
Maybe your sperm production is severly reduced by estradiol?

 

[Moosey]

Nolva is going to wreck your hair because it antagonizes estrogen in most places except brain and liver. Use raloxifene, it's even a mild agonist in skin and it's also more effective against gyno.

Nolva specifically targets breast tissue.
Very interesting about ralox. I knew people use it to prevent gyno but on the other hand, its used in post-menopausal women for the treatment of osteoporosis. How? Because its indeed an agonist for the ER. Which makes little sense because you'd think it would cause gyno, or atleast do nothing to prevent it.

"The active substance in Evista, raloxifene, is a selective oestrogen receptor modulator (SERM). Raloxifene acts as an ‘agonist’ of the oestrogen receptor (a substance that stimulates the receptor for oestrogen) in some tissues in the body. Raloxifene has the same effect as oestrogen in the bone, but it does not have an effect in the breast or the womb." https://www.ema.europa.eu/en/documents/overview/evista-epar-summary-public_en.pdf

Shame tho, i cant find ralox anywhere. I can buy nolva like candy though. Either way, Nolva is a better choice than stuff like aromasin or arimidex.

 

[Ikarus]

Thats the first time I know it. Most studies never mentioned anything about bica stopping sperm production, only a decrease. Though you can stop it if you're trying to conceive then get on it.
Maybe your sperm production is severly reduced by estradiol?

Studies mention how it doesn't have an effect on your testicles, or spermatogenesis, but it's still an anti-androgen and will stop your sperm production whilst you're on it. Anyone who is on bicalutamide and still produces sperm are either lying, or lying.

 

[StevenGerrard]

I think you should add oral minoxidil. I’m using oral minoxidil soon, since my frontal isn’t making the progress I want it to.

dosage? regardless... expect a 4-6 week shed

 

[Ikarus]

dosage? regardless... expect a 4-6 week shed

That’s fine, as long as the benefits will help my frontal a little.

 

[Ikarus]

dosage? regardless... expect a 4-6 week shed

I forgot to say the dosage, I’m thinking of 2.5mg/day. Have you used it? If so, where did you get it?

 

[baba_yaga]

Studies mention how it doesn't have an effect on your testicles, or spermatogenesis, but it's still an anti-androgen and will stop your sperm production whilst you're on it. Anyone who is on bicalutamide and still produces sperm are either lying, or lying.

I remember DHTcel said one can stop bica for a few months after years of usage, due to bica's degrading the corepressor genes, right?

 

[Ikarus]

I remember DHTcel said one can stop bica for a few months after years of usage, due to bica's degrading the corepressor genes, right?

Don't trust everything he says, he also said that bicalutamide made him produce more sperm.

 

[StevenGerrard]

I forgot to say the dosage, I’m thinking of 2.5mg/day. Have you used it? If so, where did you get it?

I haven't used it, it's tempting though. I have a mild heart condition (mitral valve prolapse) therefore making it dangerous for me to take it -- however if I were to take it that would be the ideal dosage (from what I've read) 2.5mg/day, supposedly taking it at night (right before you go to sleep) is advised since your heart will be at a comfortable resting rate, obviously look into all this (research and whatnot).

 

[Derelict]

I haven't used it, it's tempting though. I have a mild heart condition (mitral valve prolapse) therefore making it dangerous for me to take it -- however if I were to take it that would be the ideal dosage (from what I've read) 2.5mg/day, supposedly taking it at night (right before you go to sleep) is advised since your heart will be at a comfortable resting rate, obviously look into all this (research and whatnot).

Even 0.6mg can be effective, look in to it more, heart isn't something you want to f*** around with but you may be able to use minoxidil if you are careful.

 

[Jacob Williams]

It’s so unfortunate that I can’t get a prescription for the medications I’m on. If I could I’d be able to get them at less than 1/4 the price I currently pay. $1,600 is a lot to pay for hair, but it’s worth it if that’s what I have to do.

 

[Derelict]

It’s so unfortunate that I can’t get a prescription for the medications I’m on. If I could I’d be able to get them at less than 1/4 the price I currently pay. $1,600 is a lot to pay for hair, but it’s worth it if that’s what I have to do.

$1600 a year for dutasteride, minoxidil and nizoral?

 

[Moosey]

It’s so unfortunate that I can’t get a prescription for the medications I’m on. If I could I’d be able to get them at less than 1/4 the price I currently pay. $1,600 is a lot to pay for hair, but it’s worth it if that’s what I have to do.

You are getting scammed bro, prescription meds are more expensive in my country than generics

 

[Ikarus]

It’s so unfortunate that I can’t get a prescription for the medications I’m on. If I could I’d be able to get them at less than 1/4 the price I currently pay. $1,600 is a lot to pay for hair, but it’s worth it if that’s what I have to do.

You would have to visit a gender specialist for them

 

[baba_yaga]

Don't trust everything he says, he also said that bicalutamide made him produce more sperm.

Once on bica, forever on bica. No sperm production. Thats sad. Is he on the discord server?