Replicel Is On Fire Lately — Data In Feb.

[Noisette]

Shiseido has readjusted doses and the number of injections per patient.
I think there were three injections included in the trial, but I ain't 100% sure.

+1 Yes exactly

here is the link of the study (Shiseido) :
https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000026894

 

[SkinDiesel]

Anybody else optimistic that Shiseido + Follica could act as a functional cure for many?

 

[d3nt3dsh0v3l]

Nope, Aderans failed to amplify mesenchymal stem cells (=dermal papillae) and that is why it ended.
On the other hand, Replicel achieved in amplifying another strand of cells, the sheath cup ones, and that is why Shiseido bought RCH-01 for the Asian market.
What's interesting is that Tsuji's trying to amplify those stem cells, Aderans failed to amplify, and, if he succeeds, those stem cells could be injected, as well.
I'm pretty confident that the injection of epithelial and mesenchymal stem cells will be proven to be a rather effective treatment for halting hair loss (presumably even restoration!).

I may not know the exact details about what strand of cells they multiplied or not but im 100% sure when i searched about the aderans trials they managed to halt all hairloss similar to Rch01 but they didnt manage regrowth, they had a viable hairloss treatment and they threw it away because it didnt produce any significant cosmetic result

We should be careful about which is which, because I think that the principle behind RCH-01 and Riken is pretty different.

Go to 3:20 (since this site doesn't allow time stamped embedding).
You see that what Ken has shown is that if you take dermal and epithelial cells and put them in a medium, they find each other and assemble into organoids and bear hair. The thinking then was, what if we injected both cells into the skin - wouldn't we expect the same?

Go to 5:00

What Replicel has shown is that if you only inject dermal sheath cup cells (which are thought to produce dermal papilla cells - the ones that actually make the hair), then they integrate themselves into existing dying follicles and rejuvenate them (they have also tried other cells but DSCs gave the best results so this is part of the "official" product). So no new follicles or massive density increase but maintenance.

Perhaps what happened with Aderans is that self-assembly of hair was expected but instead a maintenance therapy was discovered. I am not too sure.

What Tsuji is trying to do is create in lab the organ germ for a follicle, which is essentially a partially organized ball of epithelial and mesenchymal cells, and then to inject that germ into the scalp, where it should complete development and hopefully integrate very well with the scalp, for example connected to the arrector pili muscle, which in turn may direct the assembly of the follicle with the natural hair pattern alignment. The cool thing about Tsuji is that he has shown that this does indeed work as intended (in mice, even with using human cells). Now we wait for them to do it on humans

As a side note, mesenchymal stem cells differentiate into several useful cell types, so solving this culturing problem is a big deal for Tsuji since he is interested in organ regeneration in general. His book Organ Regeneration is really cool stuff.


Perhaps someone more knowledgeable can correct and/or append me if I have stated anything incorrectly.

 

[thomps1523]

Anybody else optimistic that Shiseido + Follica could act as a functional cure for many?

That’s my biggest question... depends on if sheisido can turn vellus hairs terminal.

 

[br1]

We should be careful about which is which, because I think that the principle behind RCH-01 and Riken is pretty different.

Go to 3:20 (since this site doesn't allow time stamped embedding).
You see that what Ken has shown is that if you take dermal and epithelial cells and put them in a medium, they find each other and assemble into organoids and bear hair. The thinking then was, what if we injected both cells into the skin - wouldn't we expect the same?

Go to 5:00

What Replicel has shown is that if you only inject dermal sheath cup cells (which are thought to produce dermal papilla cells - the ones that actually make the hair), then they integrate themselves into existing dying follicles and rejuvenate them (they have also tried other cells but DSCs gave the best results so this is part of the "official" product). So no new follicles or massive density increase but maintenance.

Perhaps what happened with Aderans is that self-assembly of hair was expected but instead a maintenance therapy was discovered. I am not too sure.

What Tsuji is trying to do is create in lab the organ germ for a follicle, which is essentially a partially organized ball of epithelial and mesenchymal cells, and then to inject that germ into the scalp, where it should complete development and hopefully integrate very well with the scalp, for example connected to the arrector pili muscle, which in turn may direct the assembly of the follicle with the natural hair pattern alignment. The cool thing about Tsuji is that he has shown that this does indeed work as intended (in mice, even with using human cells). Now we wait for them to do it on humans
View attachment 76164

View attachment 76162
As a side note, mesenchymal stem cells differentiate into several useful cell types, so solving this culturing problem is a big deal for Tsuji since he is interested in organ regeneration in general. His book Organ Regeneration is really cool stuff.


Perhaps someone more knowledgeable can correct and/or append me if I have stated anything incorrectly.

I think you got it right. At least I have interpreted it the same.

Riken = building new follicles "from scratch", by putting some cells together.
RCH-01 = injecting one type of cell, which would migrate to the follicle, regenerating it - because DHT destroys these cells. The new cells being injected, are from immune follicles. (Note: on Replicel's promotional video, they say it "could happen" for new follicles to be formed - so I believe they are still to find out if it will happen)..

 

[Georgie]

That’s my biggest question... depends on if sheisido can turn vellus hairs terminal.

Salivating at the thought of this

 

[Georgie]

I’m super excited about all of this, but then I wonder: is this going to be available in my country? How much am I going to have to pay for this? Aaaand I feel depressed again

 

[Georgie]

I'm hoping for a neogenesis of 15-25 follicles/cm² and immunized follicles for at least 2 years thanks to Shiseido.
Let's see if it can bring back diminished hairs back too ( at least it should do that, because of the immunization)

Cross your fingers

Totally dreaming about showering without my hairs melting out of my head. Thick hair that can be easily styled and looks good without effort. Not envying everyone who has normal hair. God I hope this comes out soon.

 

[Georgie]

Nope treatment should cost 1k.
They are testing how often and how much of the product should be used for the best results

Just tread a f*****g cap filled with stem cells needles and juice me up. Straight to every single follicle please.

 

[Georgie]

Lol idk who nameless is and i honestly don't give a f***, just give me my replicel and my Brotzu and you can call me anything you want.

Yes

 

[razzmatazz91]

Why? I don't think repli has a bad reputation.

They're no histogen.

Poor poor reputation as a company. A dozen employees, and the only product being sold...or sale being attempted, is an injector.
Check out views of investors and stock prices.

I actually feel good about Shiseido working on the tech. Look what happened to the other companies who tried: https://www.hairlosscure2020.com/lessons-from-aderans-and-intercytexs-hair-multiplication-failures/

It seems that all the stem cell people are circling around the same turd, metaphorically. They don't have it perfect, but by now, they have tried several things and have bits of phase 1 and phase 2 data to show. One of these people may get it right. Running out of money before finishing product development seems like a common failure mode. I think Shiseido may be less prone to that. In fact, I think it is advantageous for them to pick up a disruptive technology that has been shown to yield SOME results, and then use their money and expertise to worry about product development and scale up, which they should be good at.

Shiseido on the other hand is a cosmetic giant in Japan. Agreed. Shiseido is the only reason I have faith in RCH-01

 

[MrV88]

I think you got it right. At least I have interpreted it the same.

Riken = building new follicles "from scratch", by putting some cells together.
RCH-01 = injecting one type of cell, which would migrate to the follicle, regenerating it - because DHT destroys these cells. The new cells being injected, are from immune follicles. (Note: on Replicel's promotional video, they say it "could happen" for new follicles to be formed - so I believe they are still to find out if it will happen)..

I think that Shiseido is the real deal in the whole process, as far as I know they got their own product/research for hair growth that hasn't been licensed and therefore an enhanced or maybe even combined treatment could well be available.

A whole new research facility is quite an impressive move for "just a sideless mantaining".

Even bioxcin or minoxidil adversed hair regrowth, really can't wait for the release of this.

 

[That Guy]

Anybody else optimistic that Shiseido + Follica could act as a functional cure for many?

I am betting on it.

At worst, Follica will be able to offer the results of the Dhurat study, which would already be enough for me and many others.

We also know that the process can be repeated, and I've yet to hear one (scientific) argument that can explain why the results couldn't be increased further with repeat sessions.

With RCH-01, we know that your hair will remain steadfast for at least five years, but possibly indefinitely as intended.

For me, 2018 is a big deal for my hair because I'm waiting to see the Shiseido results and if Follica begins their pivotal or not. I really don't want to do a transplant if I don't have to. But I'm not a high Norwood, so it's better than nothing if it comes down to it and the meds have worked brilliantly for me.

Either way, I'll be back to being a "fullhead oppressor" before my 30s and that is a comforting feeling.

 

[Georgie]

I am betting on it.

At worst, Follica will be able to offer the results of the Dhurat study, which would already be enough for me and many others.

We also know that the process can be repeated, and I've yet to hear one (scientific) argument that can explain why the results couldn't be increased further with repeat sessions.

With RCH-01, we know that your hair will remain steadfast for at least five years, but possibly indefinitely as intended.

For me, 2018 is a big deal for my hair because I'm waiting to see the Shiseido results and if Follica begins their pivotal or not. I really don't want to do a transplant if I don't have to. But I'm not a high Norwood, so it's better than nothing if it comes down to it and the meds have worked brilliantly for me.

Either way, I'll be back to being a "fullhead oppressor" before my 30s and that is a comforting feeling.

Wonder if it will work for a girl with 75% miniturisation with diffuse hairloss of scalp, eyebrow and eyelash hair.
My hairloss is so fast it’s frightening. I honestly wonder if anything will save me.

 

[That Guy]

Wonder if it will work for a girl with 75% miniturisation with diffuse hairloss of scalp, eyebrow and eyelash hair.
My hairloss is so fast it’s frightening. I honestly wonder if anything will save me.

Yep. Not sure about the eyebrow and eyelash hair

but Follica and Shiseido will work on women too.

 

[Georgie]

Yep. Not sure about the eyebrow and eyelash hair

but Follica and Shiseido will work on women too.

I guess I can always use bimatoprost on my facial hair, which does work well. Fingers crossed this comes out soon and isn’t going to cost and arm and a leg. I hate to sound melodramatic but things like this and Brotzu are the tiny little glimmers of hope that stop me from necking myself.

 

[MrV88]

I am betting on it.

At worst, Follica will be able to offer the results of the Dhurat study, which would already be enough for me and many others.

We also know that the process can be repeated, and I've yet to hear one (scientific) argument that can explain why the results couldn't be increased further with repeat sessions.

With RCH-01, we know that your hair will remain steadfast for at least five years, but possibly indefinitely as intended.

For me, 2018 is a big deal for my hair because I'm waiting to see the Shiseido results and if Follica begins their pivotal or not. I really don't want to do a transplant if I don't have to. But I'm not a high Norwood, so it's better than nothing if it comes down to it and the meds have worked brilliantly for me.

Either way, I'll be back to being a "fullhead oppressor" before my 30s and that is a comforting feeling.

Just two words: saturation point

İf this really could enhance the results by simply repeating sessions it's definitely a cure, but if it's just possible to achieve a certain goal of 20-30% a saturation point would be reached and further treatments could yield to nothing more than mantaining.

So the basic question about the Follica thing is not if it works or not, but rather:

"Can it or can it not "CREATE" new follicles from scratch"

 

[MrV88]

Wonder if it will work for a girl with 75% miniturisation with diffuse hairloss of scalp, eyebrow and eyelash hair.
My hairloss is so fast it’s frightening. I honestly wonder if anything will save me.

Some guys around here and German forums are talking about tranny drugs that could fully bring lost hair back, don't know if it really could work, but as a girl you shouldn't have the same sides like a guy? Ever tried something like that?

 

[Georgie]

Just two words: saturation point

İf this really could enhance the results by simply repeating sessions it's definitely a cure, but if it's just possible to achieve a certain goal of 20-30% a saturation point would be reached and further treatments could yield to nothing more than mantaining.

So the basic question about the Follica thing is not if it works or not, but rather:

"Can it or can it not "CREATE" new follicles from scratch"

Let us pray that it can. Cause I need 75% of me head’s worth. Jesus Christ I hope it works.

 

[Georgie]

Some guys around here and German forums are talking about tranny drugs that could fully bring lost hair back, don't know if it really could work, but as a girl you shouldn't have the same sides like a guy? Ever tried something like that?

So my hormone profile to begin with was menopause level estrgogen, sky high cortisol, perfect storm for hair loss. It began very aggressive and within a year of noticin my hair was getting thinner, may hairline had fully miniturised and I was like a NW2. It was like all the hair that I lost was growing back miniturised. It also affected my brows and lashes which grew back shorter and thinner. My body hair also grew back slow and patchy. I got a few scalp biopsies done which confirmed Androgenetic Alopecia. So I was already put onto Diane35 which is 2mg cypro acetate with 35mg ethinyl estradiol which is a HUGE amount of estrogen. The ratio of ethinyl estradiol to normal estrogen is something like 3 x the amount. That never stopped my hairloss. Then I tried 200mg spironolactone ontop of that for 9months. Nothing. Then I added topical 5% minoxidil and 2mg oral minoxidil which did regrow some hair, but in a weird pattern. I regrow a lot of hair for maybe 3 months, then for another 4-6 months my hair starts to fall out, doesn’t grow or grows back miniturised again. I get hairline recession. Then I’ll go through a short burst of regrowth for another few months and the cycle repeats itself. I lost a fair amount of hair a day but it’s not like a Telogen Effluvium shed. Usual sort of genetic hairloss shed of 50-100 hairs in the shower and maybe a 20-40 more throughout the day. I lose mostly miniturised and short hairs.
Lately for the past month I have begun taking 0.5mg avodart daily, and also started using 5% ru twice a day in minoxidil with niacinamide mixed in. I also take heaps of vitamins, castor oil, use pyothione olamine zinc shampoo, exercise every day, you name it. My hair is still receding (again) and I notice tons and tons of miniturised hairs falling out, and short cycled hair. I plan on switching topical minoxidil for stemoxydine and possibly add some adenosine in to see if it reawakens my hair follicles to not just grow for three f*****g months out of the year. Otherwise, I feel like I’m fucked. I can’t come off minoxidil altogether because I will literally lose all my hair. It will destroy anything I have left plus my brows and lashes. I don’t know how else to break this weird pattern of hairgrowth. I’m lost and really hopeless to be honest. I don’t believe taking extra estrogen will help, and I’d like to avoid it if I can.
I’m praying PRAYING that Brotzu and Follica come through this year. Something. Literally anything.