Replicell 2018 Shareholder Update Some Added Words

[cocona]

https://replicel.com/20180125-2/

In 2018, shareholders should expect to see:

• The launch of a European multi-centre, phase 2 clinical trial measuring the impact of RCS-01 injections on aging skin.
• Completion of commercial-grade prototypes for the RCI-02 dermal injector.
• Filing of a CE-mark application for our dermal injector seeking the regulatory marketing approval needed to commercially launch the device in Europe and Hong Kong.
• Preparations for launching the device in Hong Kong by licensing partner, YOFOTO (China) Health Industry Co. Ltd.
• Data from the clinical research being funded by Shiseido in Japan measuring the benefit of RCH-01 injections in men and women suffering from hair loss due to androgenic alopecia.
• Data from the research program at UBC identifying different genetic marker expression profiles of various cell populations in the hair follicle with an aim of potentially improving cell selection, manufacturing, and clinical outcomes.
• The launch of tendon repair (RCT-01) and skin rejuvenation (RCS-01) clinical trial activity in Hong Kong and/or Mainland China funded by YOFOTO.
• The launch of planned product development projects with various partners intended to add significant value to our programs.
• A meeting with the FDA reviewing one or more of our programs.
• Business development activity which may well lead to the execution of other commercial partnerships.

Unlike previous years, not only are we are financed to move through these milestones, we have new, significant non-dilutive funding commitments for much of this expansion, subject to successful closing of the deal with YOFOTO.

My guess is they wont want to start phase 3's unless they know the FDA is going to force them to. At least t hey have money by closing their deal with YOFOTO.

 

[ffar1989]

Actually just makes me wonder, did Shiseido ever post anything since they starter Phase 2? Something like, "hey we are still alive and going on"?

 

[Bitless]

Actually just makes me wonder, did Shiseido ever post anything since they starter Phase 2? Something like, "hey we are still alive and going on"?

no, but I have been contacted with them, they told me they are doing the phase II trials and it's too early to tell anything.

 

[br1]

Actually just makes me wonder, did Shiseido ever post anything since they starter Phase 2? Something like, "hey we are still alive and going on"?

Its been said in a couple interviews and articles. Shiseido started the trial mid 2016. They MUST release the results to Replicel - it's in their partnership contract.

Data is expected around summer this year (Q2 2018).

Fingers crossed for good results.

 

[cocona]

Its been said in a couple interviews and articles. Shiseido started the trial mid 2016. They MUST release the results to Replicel - it's in their partnership contract.

Data is expected around summer this year (Q2 2018).

Fingers crossed for good results.

Is that this?

Data from the research program at UBC identifying different genetic marker expression profiles of various cell populations in the hair follicle with an aim of potentially improving cell selection, manufacturing, and clinical outcomes.

I know we already got an amazing paper on gene expression recently but I wouldn't mind more data especially with the relation to cell types.

 

[br1]

Is that this?



I know we already got an amazing paper on gene expression recently but I wouldn't mind more data especially with the relation to cell types.

Here: https://replicel.com/replicel-provides-update-shiseido-license-co-development-rch-01/

Here: https://replicel.com/wp-content/uploads/2017/01/RepliCel-Presentation-Jan-2017.pdf

 

[br1]

I have good hopes for this treatment.. It might not be a cure in terms of reversal, but from the 5 year data, we know for a fact that all patients "hairloss was stabilized" - It is a bit vague statement, but if it means hairloss stopped, it's huge. Right?

Then some regrowth is welcome.

Plus, they once said the "regenerated" follicles become immune to DHT, since the injected cells come from immune follicles (safe zone).

 

[MrV88]

I have good hopes for this treatment.. It might not be a cure in terms of reversal, but from the 5 year data, we know for a fact that all patients "hairloss was stabilized" - It is a bit vague statement, but if it means hairloss stopped, it's huge. Right?

Then some regrowth is welcome.

Plus, they once said the "regenerated" follicles become immune to DHT, since the injected cells come from immune follicles (safe zone).

I somehow can't imagine that injecting amplified cells shouldn't result in new hair follicles. Doesn't make f*****g sense at all.

 

[Hate da Bt]

I have good hopes for this treatment.. It might not be a cure in terms of reversal, but from the 5 year data, we know for a fact that all patients "hairloss was stabilized" - It is a bit vague statement, but if it means hairloss stopped, it's huge. Right?

Then some regrowth is welcome.

Plus, they once said the "regenerated" follicles become immune to DHT, since the injected cells come from immune follicles (safe zone).

I somehow can't imagine that injecting amplified cells shouldn't result in new hair follicles. Doesn't make f*****g sense at all.

In theory, dermal sheath cup cells, the ones injected, relocate to the sheath cups of hair follicles in the balding areas, which results in the immunization of the hf and the de-miniaturization of those hf which have been miniaturizing (hence the increase in hair density).

 

[br1]

In theory, dermal sheath cup cells, the ones injected, relocate to the sheath cups of hair follicles in the balding areas, which results in the immunization of the hf and the de-miniaturization of those hf which have been miniaturizing (hence the increase in hair density).

Yes, but if I remember well, in one of Replicel's videos, they theorized that the injected cells could potentially clump together to form new follicles.. It was an assumption, though.. Trials will answer!

 

[dermrafok]

Yes, but if I remember well, in one of Replicel's videos, they theorized that the injected cells could potentially clump together to form new follicles.. It was an assumption, though.. Trials will answer!

What would be a good result for you in terms of numbers?

 

[Hate da Bt]

Yes, but if I remember well, in one of Replicel's videos, they theorized that the injected cells could potentially clump together to form new follicles.. It was an assumption, though.. Trials will answer!

That's impossible.
You need stem cells, epithelial and mesenchymal, to create primordia.
Dermal sheath cup cells are not stem cells, therefore, nope, they can't interact with epithelial stem cells.
Neogenesis is not something this treatment can achieve, in my opinion.

 

[ffar1989]

Yep... I never understood idea of creating new follicles, but hoping for reborn of weak one into healthy great hair and of course for protect rest of hair from DHT. Then some hair transplant clinic with can do dense packing, and restore hairline. That's sounds really nice.

And btw. If RCH-01 will truly make hair save from DHT, we can easily say that there is cure for Hair Loss. Not cure in sense of having regrowth in bald scalp but if you can stop it, that is going to be a cure for losing it.

 

[MrV88]

That's impossible.
You need stem cells, epithelial and mesenchymal, to create primordia.
Dermal sheath cup cells are not stem cells, therefore, nope, they can't interact with epithelial stem cells.
Neogenesis is not something this treatment can achieve, in my opinion.

So the first Replicel video and the presentation as well as an increase in hair count is absolutely not possible?

 

[ffar1989]

So the first Replicel video and the presentation as well as an increase in hair count is absolutely not possible?

No. I think it is more like finasteride giving greater density by rebuilding weak hairs, sometimes maybe totally missed by ourselves.

 

[Hate da Bt]

So the first Replicel video and the presentation as well as an increase in hair count is absolutely not possible?

In my opinion, yes, absolutely not feasible.

 

[MrV88]

In my opinion, yes, absolutely not feasible.

No. I think it is more like finasteride giving greater density by rebuilding weak hairs, sometimes maybe totally missed by ourselves.

FFFFFFFFUCK....

 

[Hate da Bt]

FFFFFFFFUCK....

Y?
If it, indeed, immunizes hf and de-miniaturizes those in miniaturization, it's a great treatment.

 

[Junior2491]

Y?
If it, indeed, immunizes hf and de-miniaturizes those in miniaturization, it's a great treatment.

When you say De-Miniaturize you mean have the hair grow back thicker correct? If so this along with a hair transplant and that is pretty much a cure for those of us who have not lost too much hair as it is.

 

[MrV88]

Y?
If it, indeed, immunizes hf and de-miniaturizes those in miniaturization, it's a great treatment.

Because it means that I'm going to need a transplant plus two flights to Japan, so the rest won't fall out anymore.
So it seems like that the best time for a transplant would be after several months of a Shiseido immunization.