Replicell 2018 Shareholder Update Some Added Words

[Hate da Bt]

When you say De-Miniaturize you mean have the hair grow back thicker correct? If so this along with a hair transplant and that is pretty much a cure for those of us who have not lost too much hair as it is.

Exactly, thicker and longer.
But nobody knows whether RCH-01 works or not.
This year we should know, though.

 

[MrV88]

Exactly, thicker and longer.
But nobody knows whether RCH-01 works or not.
This year we should know, though.

Don't we already know from the safety trials thats treatment definitely is an immunization for at least 2 years? 5 years data incoming

 

[hairloss_user]

It does work. Replicel's results proved that. Shiseido used more injections, so it should be more effective. Anything that can stop hairloss and increase density over 15-20% sounds good to me. Perfect treatment for those that are thinning like myself.

 

[Hate da Bt]

It does work. Replicel's results proved that. Shiseido used more injections, so it should be more effective. Anything that can stop hairloss and increase density over 15-20% sounds good to me.

2 years ain't nothing.
5-year data is more indicative of how effective the treatment may be.

 

[MrV88]

2 years ain't nothing.
5-year data is more indicative of how effective the treatment may be.

Getting an injection every two years would be quite pleasant for a lot of people instead of taking daily pills etc. and the most important point is that an early 2019 + 2 year immunization would save us till Tsuji

 

[Hate da Bt]

Getting an injection every two years would be quite pleasant for a lot of people instead of taking daily pills etc. and the most important point is that an early 2019 + 2 year immunization would save us till Tsuji

There can't be a 2-year immunization, arkadaș. It makes no sense scientifically.

 

[MrV88]

There can't be a 2-year immunization, arkadaș. It makes no sense scientifically.

Explain me why not

 

[Hate da Bt]

Explain me why not

Why should the sheath cup cells face demise at the end of the second year?
Makes no sense.

 

[ffar1989]

Same. It seams to be totally crazy idea of 2-year immunization. I don't know from where you took it. Histogen from other hand... But f*** them. They are dead to me.

 

[MrV88]

Why should the sheath cup cells face demise at the end of the second year?
Makes no sense.

Don't know..why are we getting bald? You know the answer? Maybe something will even kill them like our beloved hair. I'm not Shiseido or don't exactly how this works, we'll see from the results what's the real deal.

 

[br1]

Why the 2 years mark?

Replicel's 5 years trial (phase1) showed the hairloss was halted for the 5 year period, with little decline.

 

[Hate da Bt]

Don't know..why are we getting bald? You know the answer? Maybe something will even kill them like our beloved hair. I'm not Shiseido or don't exactly how this works, we'll see from the results what's the real deal.

We get bald because our hf cells are susceptible to DHT.

 

[br1]

Replicel treatment in a nutshell:

1.Find that hair follicles that miniaturized are all missing DSC cells.
2.Find that all hair follicles in the "safe zone" still have their DSC cells intact.
3.Extract DSC cells from safe zone hair follicles.
4.Multiply extracted DSC cells to the millions
5.Inject new cells back to the scalp on the balding areas.
6.Injected cells migrate to weak follicles to re-populate the missing DSC cells, and thus making the follicle healthier again (and immune to DHT, since they are originated from immune HF).

 

[Junior2491]

Replicel treatment in a nutshell:

1.Find that hair follicles that miniaturized are all missing DSC cells.
2.Find that all hair follicles in the "safe zone" still have their DSC cells intact.
3.Extract DSC cells from safe zone hair follicles.
4.Multiply extracted DSC cells to the millions
5.Inject new cells back to the scalp on the balding areas.
6.Injected cells migrate to weak follicles to re-populate the missing DSC cells, and thus making the follicle healthier again (and immune to DHT, since they are originated from immune HF).

This is what I was expecting from Shiseido. Hopefully it is released late this year or early next. That would be huge.

 

[GotHair?]

There can't be a 2-year immunization, arkadaș. It makes no sense scientifically.

I don't think you fully understood what others tried to convey there.
Basically Phase 1 of Replicel's trial had three data points (after 6 months, after 2 years and after 5 years.
We have the effectiveness data for 6 months mark and 2 year mark. Basically we know that majority of trial participants after 2 years had a net positive of terminal hair compared to pre-treatment time. There were those that lost some hair but I think the worst one was -4% (not sure though). This means that majority should have more or same amount of terminal hair after 2 years. This does not mean that day later after 24 months you are gonna start losing hair rapidly. It is basically like a warranty in a car.
You know you'll always have a serviced working car covered by the dealership. After the warranty expires it may break the day after or it may keep on running for the next decade.

They did allude like br1 mentioned that the effect went on for 5 years. It is unconfirmed at this point.
However a lot of people here are missing the bigger picture with RCH-01. If you are a responder for the treatment and you do successfully immunize your hair. That means there might be a lot of velus hair that stopped getting attacked by DHT. What happens if you use another treatment at your disposal (minoxidil, setipripant, follicum, hell maybe even Rivertown) who knows how RCH-01 will respond in conjuction with other treatments. Maybe once those DSC cells migrate to hair follicles that didn't go fibrosis you can revive them again...
Who knows...
But still if it is just a vaccine that works, RCH-01 will be valuable.

 

[ffar1989]

Well DHT is worse enemy of hair, but they are other factors as well. Stress, some drugs, illness etc etc. There are people out there, who have very weak donor area as well. And let's not forget that follicles has it's own life time even this in donor area. It can die naturally without help of DHT.

 

[Ikkaku]

I'm more interessed in Shiseido's data than replicel's. But it's still good.

 

[br1]

For sure, it's all eyes on Shiseido now. Replicel will still take time to start a Phase2 (assuming they will at all).

This can be huge addition to the big3. That's my point of view so far.

The trial can also be a failure, true. But they must share the results with Replicel, it's on their contract. So I imagine we will know if it works or not. Unlike some other treatments that just vanish in time, never to be heard again.

 

[ffar1989]

I'm more interessed in Shiseido's data than replicel's. But it's still good.

Well if I understand currect, Replicell if they would start Phase 2 today, it still in best scenario wouldbe relesed were in 2022/2023?

 

[Junior2491]

Well if I understand currect, Replicell if they would start Phase 2 today, it still in best scenario wouldbe relesed were in 2022/2023?

That is for the US. Shiseido stated they are aiming for commercial release in Japan later this year or early next if all works out.