spironolactone
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Resistance to antiandrogens/5ar inhibitors/minoxidil
- Thread starter dar3k
- Start date
- Reaction score
- 51
I almost tried everything that exists.
Nothing ever gave real terminal regrowth.
finasteride ru and minoxidil gave some vellus.
After years of dutasteride and topical minoxidil use, i switched to oral minoxidil.
Im at about 12mg daily now.
It gave me new vellus till N0 on my left temple. Right side very little.
But nothing really terminal.
Bro, these things just barely maintain. That's reality sometimes....
Nothing ever gave real terminal regrowth.
finasteride ru and minoxidil gave some vellus.
After years of dutasteride and topical minoxidil use, i switched to oral minoxidil.
Im at about 12mg daily now.
It gave me new vellus till N0 on my left temple. Right side very little.
But nothing really terminal.
Bro, these things just barely maintain. That's reality sometimes....
- Reaction score
- 51
No, my hair is pretty dry. No sides from dutasteride. I only noticed some gyno and maybe slightly lower libido from estradiol.
RU, finasteride, dutasteride, enzalutamide, valproic acid, estriol were all side effect free.
RU, finasteride, dutasteride, enzalutamide, valproic acid, estriol were all side effect free.
Same, no side effects from finasteride, dutasteride, RU, minoxidil oral/topicalNo, my hair is pretty dry. No sides from dutasteride. I only noticed some gyno and maybe slightly lower libido from estradiol.
RU, finasteride, dutasteride, enzalutamide, valproic acid, estriol were all side effect free.
- Reaction score
- 34
Me too. Tried all the same things as you and had no results from any of it.Same, no side effects from finasteride, dutasteride, RU, minoxidil oral/topical
- Reaction score
- 34
Yeah I researched that and it’s not a route I’m willing to take right now as that path comes with the risk of pretty serious side effects. The tumour thing in particular is very scary. My goal is to just try and hold onto as much as I can until Kintor/Breezula or any future treatments come out as there’s some promising stuff in the future.Maybe Its worth to try low doses of CPA (12.5mg?) to nuke some androgens? It wont feminize us, the only risk is gynecomastia and reversible sterility.... but im a bit scared of brain tumors, Addison disease after withdrawal etc.
I found that the Risk of brain tumor when you use 12.5mg ed for 1 year is 0.00023%Yeah I researched that and it’s not a route I’m willing to take right now as that path comes with the risk of pretty serious side effects. The tumour thing in particular is very scary.
like 23 people / 100000
- Reaction score
- 34
I’m sure that’s true but that isn’t the only side effect. I haven’t researched all of the issues involved with using CPA in a long time but it creates lots of new issues. You can’t expect to alter hormones and not create new problems.I found that the Risk of brain tumor when you use 12.5mg ed for 1 year is 0.00023%
Yeah.. I know that’s why Im scared tooI’m sure that’s true but that isn’t the only side effect. I haven’t researched all of the issues involved with using CPA in a long time but it creates lots of new issues. You can’t expect to alter hormones and not create new problems.
Last edited:
H
How long have you been on each drug?Upped my RU to 150mg daily I started taking Alpicort E aswell. After starting Alpicort my scalp itching is almost gone.. however my hairs falling out in the same rate... im loosing hope.
My current regime is:
Morning:
-5% Minoxidil topical + 0.5mg Dutasteride oral + 1mg finasteride oral + 2.5mg Minoxidil oral
Evening;
-3ml 5% RU58841 (150mg)
-5% Minoxidil topical
-2ml Alpicort E
Every week dermarolling 1.5mm
2xweek Nizoral shampoo
Still loosing ground...
Upped my RU to 150mg daily I started taking Alpicort E aswell. After starting Alpicort my scalp itching is almost gone.. however my hairs falling out in the same rate... im loosing hope.
My current regime is:
Morning:
-5% Minoxidil topical + 0.5mg Dutasteride oral + 1mg finasteride oral + 2.5mg Minoxidil oral
Evening;
-3ml 5% RU58841 (150mg)
-5% Minoxidil topical
-2ml Alpicort E
Every week dermarolling 1.5mm
2xweek Nizoral shampoo
Still loosing ground...
Tried Estriol (E3)?
- Reaction score
- 320
Drop finasteride. It’s redundant. Up oral min to 5mg. Add oral MSM for shedding. At least 10 grams a day.Upped my RU to 150mg daily I started taking Alpicort E aswell. After starting Alpicort my scalp itching is almost gone.. however my hairs falling out in the same rate... im loosing hope.
My current regime is:
Morning:
-5% Minoxidil topical + 0.5mg Dutasteride oral + 1mg finasteride oral + 2.5mg Minoxidil oral
Evening;
-3ml 5% RU58841 (150mg)
-5% Minoxidil topical
-2ml Alpicort E
Every week dermarolling 1.5mm
2xweek Nizoral shampoo
Still loosing ground...
Well give the recent stuff about 6 months and then you can try something else. Not much more to try at this point though. Next steps could be something like topical bicalutamide, or pyrilutamide if it's available. I don't see CPA being useful topically as it could possibly lower scalp estrogen. Other than that you could try upping oral min a bit.finasteride 5 years
dutasteride 2 years
Oral min 1 year
Nizoral 1 year
RU 1.5 month
Topical min 1.5 month
Dermarolling 1.5 month
Alpicort 1 week
To be honest, Im loosing hope.. I think Its over for me.Well give the recent stuff about 6 months and then you can try something else. Not much more to try at this point though. Next steps could be something like topical bicalutamide, or pyrilutamide if it's available. I don't see CPA being useful topically as it could possibly lower scalp estrogen. Other than that you could try upping oral min a bit.
Maybe you will just need to wait for things to stabilize and get a transplant. What pattern is your hair loss?To be honest, Im loosing hope.. I think Its over for me.