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Restoring Wnt/β-catenin Signaling Is A Promising Therapeutic Strategy
- Thread starter pegasus2
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Yes. Thanks!
EDIT: Dr Allan Green can provide prescription for Anti-Aging drugs in the USA. His advice is to take 5-7mg once a week vs 1mg per day.
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What dosage would you recommend?
They injected 100uM, so you need at least a 4% concentration to match that. More since you're not injecting it, but it should be well absorbed.
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It could be that activation is too broad, so there's a lack of proper structure. Mice expressing a stabilized form of beta-catenin develop malformed HFs without a proper DP (source). Also maybe overproliferation, as this study suggests.
I'm so angry that follica protocol is microneedling plus minoxidil. All these years and all they have is elevated microneedling and caveman minoxidil which I cant handle due to a heart issue. I'm soooo upset about this. .
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Why are you upset? Today you are welcome to experiment with drugs that haven't hit the market yet and help this community by reporting your results. Are you another loser waking up every morning in front of the mirror watching your balding head and coming to this forum to just vent about the lack of progress while waiting for a miracle cure thats long overdue based on your expectations? Newsflash: it didn't happen for 50 years and it's unlikely to happen in 2020. Do something about it and by this I mean don't write to your congressman.
I have ordered chemicals online several times to experiment with. I can no longer experiment due to a medical condition. Please dont respond by telling me that I should get off here and should be more concerned about my medical issue. There isnt anything I can do about it.
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Thanks for providing some background. If your medical condition stops you from experimenting with new treatments (I am sorry to hear that), what makes you think that upcoming hair treatments will be applicable to your condition? It seems that even FDA approved treatments are always denied to people with medical conditions.
SM also inhibits dkk1, according to some studies...
But then Gallocyanine can be an advantage more cheaper
For see effect it should be combined with sfrp1 inhibitor(way316606)
What is the Gallocyanine half life?
See this Page: www.hairguard.com/baldness-cure/
In the forum,Link: SM04554 phase 2 results, even in the last message it is commented
I think that if SM04554 only was a GSK3B inhibitor dont work... For example, I dont know anyone who had results with VPA
Who knows. It might do other things too. I think they say the MOA is not fully understood. I guess it's worth taking all of these if you're on something like rapamycin to inhibit mTOR.
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From the company website:
SM04690 treatment decreased the expression of Wnts signaling activators and downstream genes, e.g. Wnt3a, Dvl, Axin2, TCF4, TCF7, APC. GSK3β, CyclinD1 etc. as compared to vehicle
SM04690 treatment increased the expression of Wnt pathway inhibitors e.g. DKK1, 2, WIF1 etc. as compared to vehicle.
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Or lithium chloride, for that matter.
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I have had some minor regrowth and decent thickening from wounding with a post wound topical of 5% minoxidil, 10mg/ml LiCi, and 0.075% capsaicin. No way of telling how much is due to the LiCi of course, but wanted to share.
I have no idea if the new treatments will affect my health or not. I'm actually very anxious about that being a string possibility. I am hopeful because that's all I can be right now. And also I'd rather take a chance with an FDA approved drug as opposed to a chinese lab unapproved chemical. No brainer.