Agreed; but neither study applied topically:
'[...] we hypothesize that IVSTS [intravenous sodium thiosulfate] plays a role in abnormal bone density in calciphylaxis patients.'
'
Sodium thiosulfate administration
Sodium thiosulfate (Köhler Chemie GmbH, Alsbach, Germany) was diluted 1:3 with normal (0.9%) saline and given
i.p. [
intraperitoneal injection] three times a week in a dosage derived from STS usage in humans (0.4 g/kg body weight).
15,
16 STS treatment was started after 2 weeks of adenine diet in the ET group and after 4 weeks in the LT group, resulting in a total treatment duration of 8 and 6 weeks, respectively (
Figure 1). NUC animals were also treated with STS for 6 weeks. Control (UC) animals received normal saline i.p.'
Accelerated vascular calcification is a severe complication of chronic kidney disease contributing to high morbidity and mortality in patients undergoing renal replacement therapy. Sodium thiosulfate is increasingly used for the treatment of soft tissue calcifications in calciphylaxis...
pubmed.ncbi.nlm.nih.gov
I find these things quite a worry too:
'So-called “hardening of the arteries” leads to raised blood pressure and ultimately is a significant risk factor for thrombosis and cardiac disease. The hardening process is in fact
calcification of the blood vessel tissues with
the same mineral form as in bone, a calcium phosphate related to mineral hydroxyapatite.'
www.ch.cam.ac.uk
'Side effects may include vomiting, joint pain, mood changes,
psychosis, and
ringing in the ears.
[2]'
en.wikipedia.org
Great; we might go mad with holes in our heads.
Suddenly impotence doesn't seem so bad.