Some "way 316606" Stuff Is Making Headlines Today.

kiwipilu

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does this even have an effect on male pattern baldness? or does it just promote growth of already healthy, existing hairs?

sounds like a huge elephant in the room case to me

topical cyclosporine 5% :
5.jpg
 

SimonC

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topical cyclosporine 5% :
Where did you get these pics? Is there some research related to cyclosporine?

Quality is poor, but if we assume that it's indeed hair at the second pic, the result is pretty good. That guy completely restored his hair.

I just read about cyclosporine, this is very powerful sh*t. Unfortunately, there are a lot of sides and one of them is gyno :(
Moreover, unwanted hair growth is the side effect as well, so it's hard to say how you can target it on your head.
 

kiwipilu

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Where did you get these pics? Is there some research related to cyclosporine?

Quality is poor, but if we assume that it's indeed hair at the second pic, the result is pretty good. That guy completely restored his hair.

I just read about cyclosporine, this is very powerful sh*t. Unfortunately, there are a lot of sides and one of them is gyno :(
Moreover, unwanted hair growth is the side effect as well, so it's hard to say how you can target it on your head.

not a lot of research on this cyclosporine drug for our condition(but there is also a study for alopecia areata). surely because of the drug profile. btw the pics comes from a study from 1990...believe it or not. (see attachment)
"responding" people in the group :
"We considered successful treatment to be an increase in hair count of at least 50% after 4 months and 100% after 12 months. Only two subjects were in this category and are referred to in Table I as "responders." So I assume all the people involved noticed good improvment nonetheless.
Pic show such drug can reverse male pattern baldness. Now let's hope the "way" drug does not disappoint but the sad part is it will be a long journey until we know
 

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BetaBoy

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not a lot of research on this cyclosporine drug for our condition(but there is also a study for alopecia areata). surely because of the drug profile. btw the pics comes from a study from 1990...believe it or not. (see attachment)
"responding" people in the group :
"We considered successful treatment to be an increase in hair count of at least 50% after 4 months and 100% after 12 months. Only two subjects were in this category and are referred to in Table I as "responders." So I assume all the people involved noticed good improvment nonetheless.
Pic show such drug can reverse male pattern baldness. Now let's hope the "way" drug does not disappoint but the sad part is it will be a long journey until we know

Pretty poor response rate really.

In the WCHR 2017 proceedings, Paus ran a talk/seminar where he mentions how Cyclosporine is the most powerful of known hypertrichosis inducing medication. This intrigued me as I personally know from experience how oral minoxidil can induce hypertrichosis so was keen to see how Cyclosporine fairs. Yet despite its widespread use I’ve had much difficultly finding any documented cases besides that one 1990 single page study with a grainy picture. Anyone come across any pictures documenting cyclosporine inducing hair growth/regrowth in patients?
 

kiwipilu

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Pretty poor response rate really.

In the WCHR 2017 proceedings, Paus ran a talk/seminar where he mentions how Cyclosporine is the most powerful of known hypertrichosis inducing medication. This intrigued me as I personally know from experience how oral minoxidil can induce hypertrichosis so was keen to see how Cyclosporine fairs. Yet despite its widespread use I’ve had much difficultly finding any documented cases besides that one 1990 single page study with a grainy picture. Anyone come across any pictures documenting cyclosporine inducing hair growth/regrowth in patients?

Like I said have you read what they consider "responders?" : 100% increase in hair count after 12months. bit extreme isnt it? In comparaison, look at the recent studies for other drugs...
Anyway I doubt there are a lot of people who tried cyclosporin mixed in olive oil appart from this study and some rare people. ofc there is always a question of legitimacy for this study. but the recent news regarding the new drug (way 316606), brother of cyclosporin, makes us believe this 1990 study was (maybe) on the right path. When we look at the picture we just see a guy who completely reverses a thinning crown (100%male pattern baldness). so I think this can't be the "most powerful of known hypertrichosis" only

ps: that's a serious regimen you are on ! ; o
 

Murkey Thumb

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abcdefg

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no my friend, not cyclo, but way 316606

These guys found the main mechanism that cyclo works, and found other drugs that inhibit the same protein. They got better results with way 316606 that inhibited the same protein than even cyclo got! They tested it in HUMAN hair from 40 people. Read the articles on it.
This has way more potential than brotzu or half the other crap on this forum that will go nowhere. This might go nowhere too, but it seems pretty promising. Cyclo gets some amazing regrowth what if this stuff regrows tons of hair?
The fact they tested this, and got results on par with cyclo just by targeting this one specific protein is pretty good. We know cyclo is too dangerous to use for male pattern baldness.
 

Ollie

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Whats the actual difference between Cyclo and Way316606 ? Safety profile ?
 

yess

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Why isnt there a cyclo topical yet if there were studies in the 90's?
 

elijahwould

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Why isnt there a cyclo topical yet if there were studies in the 90's?

because there is some catch, as always.

everything always sounds perfect about these products until their efficacy has to be actually demonstrated without that bs hide and seek parody.
 

Georgie

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We can buy way316606 in this country so it does exist as a chemical but how would you even start making a topical out of it? Unless we found out how they used Cyclosporin and used that as a bench mark.

I am not a chemist so i would have to leave it to somebody who is.
I would look up what it’s solubility is and start with a 1% in whatever is can be dissolved in
 

Murkey Thumb

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I would look up what it’s solubility is and start with a 1% in whatever is can be dissolved in
I believe they used DMSO but that was for hairs that were not actually on a scalp. Maybe a 20% DMSO + distiller water mix may do it. Although i don't really like DMSO it seems to penetrate too much.
 
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