Some "way 316606" Stuff Is Making Headlines Today.

[BetaBoy]

We don't have "hairloss pathways" we have hair growth pathways and they're being shut down. The main one being the Wnt pathway. There's good evidence to suggest the Wnt pathway is THE pathway when it comes to Androgenetic Alopecia, and that drugs that are capable of upregulating it, by some method of action, will be essentially an "override switch" turning back on all the hair follicle cells that have gone dormant. I think Wnt agonists have by far the most potential compared to any other drug approach being pursued atm.

The problem is you really want to target the pathway specific to the downregulation acting on HF Wnt signaling due to Androgenetic Alopecia, a blanket upregulation of Wnt signalling is not ideal considering over expression of this pathway is implicated with increased cancer risk.

 

[LosingHairLosingPatience]

The problem is you really want to target the pathway specific to the downregulation acting on HF Wnt signaling due to Androgenetic Alopecia, a blanket upregulation of Wnt signalling is not ideal considering over expression of this pathway is implicated with increased cancer risk.

Cancer is fake news give me hair

 

[Sanchez1234]

We don't have "hairloss pathways" we have hair growth pathways and they're being shut down. The main one being the Wnt pathway. There's good evidence to suggest the Wnt pathway is THE pathway when it comes to Androgenetic Alopecia, and that drugs that are capable of upregulating it, by some method of action, will be essentially an "override switch" turning back on all the hair follicle cells that have gone dormant. I think Wnt agonists have by far the most potential compared to any other drug approach being pursued atm.

I hope you are right. How does DHT fit in the WNT theory?

 

[bboy]

I hope you are right. How does DHT fit in the WNT theory?

 

[baldco]

That is a great map bboy, However missing is the recently talked about Cxxc5 pathway leading to negative regulation of DVL1 => increased GSK3B. Increased GSK3B lowers ALP and IGF-1 crucial for DP cells to proliferate. I also found interesting again that same pathway would lead to upregulation of AR expression/activity which would continue to make the problem worse. I am not sure what leads to upregulation of Cxxc5(DHT-AR?)
After reading Choi's paper, which btw was particularly well done, I was quite excited for the Tokyo convention. Not sure what become of it.

 

[Georgie]

I’m closing the group buy off today. If you haven’t made an order then that’s it. Cheers guys.

 

[McLovin26]

I’m closing the group buy off today. If you haven’t made an order then that’s it. Cheers guys.

Keep us posted on your progress

 

[fuDHTck]

https://www.theguardian.com/fashion/2018/sep/02/hair-today-gone-tomorrow

"...Hawkshaw is no longer working on the project, but the Italian pharmaceutical company, Giuliani, hopes to take his findings through to clinical trials..."


Small trivia, Giuliani also makes the generic finasteride I use

 

[BetaBoy]

https://www.theguardian.com/fashion/2018/sep/02/hair-today-gone-tomorrow

"...Hawkshaw is no longer working on the project, but the Italian pharmaceutical company, Giuliani, hopes to take his findings through to clinical trials..."


Small trivia, Giuliani also makes the generic finasteride I use

Would Giuliani even have the capital to undergo the process of acquiring a licence for a drug like WAY-31606, glossing over their current product portfolio doesn't inspire much hope. Seems to me this would be a company that just sit on a patent until one of the big players with the actual means to commercialise like Pfizer, MSD, GSK etc come along and acquire it.

 

[alibaba92]

https://www.theguardian.com/fashion/2018/sep/02/hair-today-gone-tomorrow

"...Hawkshaw is no longer working on the project, but the Italian pharmaceutical company, Giuliani, hopes to take his findings through to clinical trials..."


Small trivia, Giuliani also makes the generic finasteride I use

Are they a big pharma, they were established in 1889 ? Do they have money to bring this to the market ?

 

[Xander94]

Any supplements that upregulate wnt ?

 

[neronero]

Any supplements that upregulate wnt ?

Ginsenosides

 

[Xander94]

Ginsenosides

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367658/

https://www.ncbi.nlm.nih.gov/pubmed/28056548

Also L-carnitine. Time to megadose

 

[br1]

Another italian pharma-show

 

[alibaba92]

Another italian pharma-show

This one got FDA trial, should be a real game. Brotzu-san is a cosmetic, so hell knows . Nevertheless, +10 years for this drug

 

[Sanchez1234]

This one got FDA trial, should be a real game. Brotzu-san is a cosmetic, so hell knows . Nevertheless, +10 years for this drug

Its being trialed this month, so for us not 10 years

 

[alibaba92]

Its being trialed this month, so for us not 10 years

Seriously ? Do you have any source saying that ?, good to hear anyway. Nevertheless, to be honest, they are pretty late as of now since other treatments have already been in phase 2, phase 3 and they are only "gonna" start phase 1. They are very likely to encounter money and delay issue later as the market will shrink when their competitors release the product and investors, even the pharma themselves, may not feel right risking too much for such a small poor market.

 

[br1]

The more companies the better

 

[Sanchez1234]

Seriously ? Do you have any source saying that ?, good to hear anyway. Nevertheless, to be honest, they are pretty late as of now since other treatments have already been in phase 2, phase 3 and they are only "gonna" start phase 1. They are very likely to encounter money and delay issue later as the market will shrink when their competitors release the product and investors, even the pharma themselves, may not feel right risking too much for such a small poor market.

Sorry, i meant trialed by members here. So no safety study so far. But we will soon enough if WAY is giving (short term) sides.

 

[alibaba92]

The more companies the better

I am wondering, how would the release of another effective treatment affect others competitors ? Severely such that they may consider dropping the project or none at all ?