Some "way 316606" Stuff Is Making Headlines Today.

whatevr

whatevr

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Georgie said:
I wouldn’t be able to import anything from legit chem traders. Customs here are so strict they don’t even allow pencils and erasers in. It’s why I have to get most of my stuff from shady asians. Bugger.
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Ah, yeah. Customs gayness. I deal with it here too.
 
whatevr

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Georgie said:
How do you get around it? The asshats here literally just throw your sh*t out or send you to court to argue your case.
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Normally I just pray that I'm really lucky. Or I work around.

I had my RU seized once and lost it, but mainly because I wasn't sure if it was legal to import and didn't want to go through the declaration process so they sent it back. The enza we got via a group buy that was re-shipped from another European country (inter-European union traffic is not subject to customs checks). And my equol came from Belgium strangely enough (despite that it was bought on Alibaba) so it did not go to customs (but even if it did it's a natural substance so they can s my d about it, I'm not breaking any laws by importing it).

The only time when you can really get into trouble is with medication or patented chemicals. However, I have no idea how you are allowed to buy estrogen from Iherb and have that pass customs. But try to get some testosterone or DHT and you're about to get buttfucked. The laws are strange.
 
Eren

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Georgie said:
Behold.

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Ridiculous indeed, but that guy went full retard and feminized himself. For most men, that is not a viable option. His description under his YouTube film says it all.

"Hair loss and bald is disaster I got from my father and my mother. I can not angry or claim money for treatment from them. They said "this problem is not their responsibility". --- 2008, I got money from parents for "carnivore man" style treatment. But it was a failed. 2009 until now, I handle my trememt budget with my own money for "herbivore man" style. --- Thanks to an old couple. She accelerated me to the dark side. I HRT like ladyboys. The result is "I am not bald". Finally, I gave a task to a ladyboy for divorce our relationship. And my life was restarted again. --- Although I meet people by pure heart . But I swear, I would not give any children born with my bald blood."
 
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sktboiboi

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SteveTabernack said:
Time to convince the Chinese to make this
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u can buy it on alibaba easily- its not a new drug or even an experimental for that matter. There are eye drop formulations that u can try rubbing on ur head.

https://en.wikipedia.org/wiki/Ciclosporin.

It looks 'new' because that study is the first study to trial it for Androgenetic Alopecia, whjen the drug has alrdy been FDA-approved for other indications.
 
whatevr

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sktboiboi said:
u can buy it on alibaba easily- its not a new drug or even an experimental for that matter. There are eye drop formulations that u can try rubbing on ur head.

https://en.wikipedia.org/wiki/Ciclosporin.

It looks 'new' because that study is the first study to trial it for Androgenetic Alopecia, but the drug has alrdy been FDA-approved for other indications.
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This is totally not what this thread is about.
 
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sktboiboi

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Eren said:
Ridiculous indeed, but that guy went full retard and feminized himself. For most men, that is not a viable option. His description under his YouTube film says it all.

"Hair loss and bald is disaster I got from my father and my mother. I can not angry or claim money for treatment from them. They said "this problem is not their responsibility". --- 2008, I got money from parents for "carnivore man" style treatment. But it was a failed. 2009 until now, I handle my trememt budget with my own money for "herbivore man" style. --- Thanks to an old couple. She accelerated me to the dark side. I HRT like ladyboys. The result is "I am not bald". Finally, I gave a task to a ladyboy for divorce our relationship. And my life was restarted again. --- Although I meet people by pure heart . But I swear, I would not give any children born with my bald blood."
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u mean u just saw this vid? it was posted 4 years ago. the uploader stated back then(when the vid's comments section were still abled) that he took Diane35, which is atually a synthetic form of oral estradiol and https://en.wikipedia.org/wiki/Cyproterone_acetate

Your breath will stink like hell(liver dysfunction) , ur arms will turn thin and flabby(look at the uploaders arms in the vid) and ur face will grow into a big pancake .

How do i know?? i tried them myself back then after watching his vid.

Unfortunately, the sides were destroying me inside out and i stopped b4 i could last long enough on the regime to see any results( i was also on spironolactone and dutasteride at the same time- though way earlier and longer than Diane35)

Based on my own experience with Diane35, the Cyperterone acetate is the 1 that's giving him most of the results and sides(i've used topical Estradiol aka Oestrogel alone, only but it didnt gave me any result and even caused more hair loss on the front)- it potently disable all the Androgen receptors in his body(which coincidentally as i've just discovered myself- it also activates the Progesterone receptor):

CPA blocks the effects of androgens like testosterone in the body, which it does by preventing them from interacting with their biological target, the androgen receptor (AR), and by reducing their production by the gonads and hence their concentrations in the body.[14] In addition, it has progesterone-like effects by activating the progesterone receptor (PR). CPA is well-absorbed, is extensively bound to plasma proteins, and has an elimination half-lifeof around 40 hours.[9][10]


Also, the uploader's hair loss was obviously affecting him severely to have let him went the feminising route, which unfortuantely, is the only way to regrow hair- but fortunately, on a localized level because those supposedly 'female' hormones are what is missing only in the balding scalp(not in normal hair-growing scalp)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/

Abstract
Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis.






and if u've read my thread, u will know Progesterone is indeed the hormone that is missing in the balding scalp
 
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meolsac

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Georgie said:
We also have no idea about dosage, best routes of administration etc
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Well, according to the paper :

HFs were cultured with 500 μL of WAY-316606 at 2 μM (Cat no. A3932, ApexBio; Houston, TX) or vehicle control (0.02% DMSO). A stock solution of WAY-316606 was made at a 10 mM concentration by adding 2,229.8 μL of DMSO (Sigma) to 10 mg of WAY-316606. This was subsequently diluted in serum-free HF media (4 μL of WAY-316606 10 mM in 19,996 μL HF media) for a working 2 μM concentration. For qRT-PCR analysis, HFs were incubated with WAY-316606 for 24 hours. To analyse β-catenin activity (ISH [AXIN2 mRNA] and immunofluorescent analysis [nuclear β-catenin]), HFs were incubated for 48 hours with WAY-316606. For hair cycle analysis, HFs were incubated with WAY-316606 up to 6 days.​

source: journals.plos(dot)org/plosbiology/article?id=10.1371/journal.pbio.2003705
 
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Kornel

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sktboiboi said:
u mean u just saw this vid? it was posted 4 years ago. the uploader stated back then(when the vid's comments section were still abled) that he took Diane35, which is atually a synthetic form of oral estradiol and https://en.wikipedia.org/wiki/Cyproterone_acetate

Your breath will stink like hell(liver dysfunction) , ur arms will turn thin and flabby(look at the uploaders arms in the vid) and ur face will grow into a big pancake .

How do i know?? i tried them myself back then after watching his vid.

Unfortunately, the sides were destroying me inside out and i stopped b4 i could last long enough on the regime to see any results( i was also on spironolactone and dutasteride at the same time- though way earlier and longer than Diane35)

Based on my own experience with Diane35, the Cyperterone acetate is the 1 that's giving him most of the results and sides(i've used topical Estradiol aka Oestrogel alone, only but it didnt gave me any result and even caused more hair loss on the front)- it potently disable all the Androgen receptors in his body(which coincidentally as i've just discovered myself- it also activates the Progesterone receptor):

CPA blocks the effects of androgens like testosterone in the body, which it does by preventing them from interacting with their biological target, the androgen receptor (AR), and by reducing their production by the gonads and hence their concentrations in the body.[14] In addition, it has progesterone-like effects by activating the progesterone receptor (PR). CPA is well-absorbed, is extensively bound to plasma proteins, and has an elimination half-lifeof around 40 hours.[9][10]


Also, the uploader's hair loss was obviously affecting him severely to have let him went the feminising route, which unfortuantely, is the only way to regrow hair- but fortunately, on a localized level because those supposedly 'female' hormones are what is missing only in the balding scalp(not in normal hair-growing scalp)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098/

Abstract
Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis.






and if u've read my thread, u will know Progesterone is indeed the hormone that is missing in the balding scalp
Click to expand...

Did you try topical diane 35? What do you think about it?
 
Murkey Thumb

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meolsac said:
Well, according to the paper :

HFs were cultured with 500 μL of WAY-316606 at 2 μM (Cat no. A3932, ApexBio; Houston, TX) or vehicle control (0.02% DMSO). A stock solution of WAY-316606 was made at a 10 mM concentration by adding 2,229.8 μL of DMSO (Sigma) to 10 mg of WAY-316606. This was subsequently diluted in serum-free HF media (4 μL of WAY-316606 10 mM in 19,996 μL HF media) for a working 2 μM concentration. For qRT-PCR analysis, HFs were incubated with WAY-316606 for 24 hours. To analyse β-catenin activity (ISH [AXIN2 mRNA] and immunofluorescent analysis [nuclear β-catenin]), HFs were incubated for 48 hours with WAY-316606. For hair cycle analysis, HFs were incubated with WAY-316606 up to 6 days.​

source: journals.plos(dot)org/plosbiology/article?id=10.1371/journal.pbio.2003705
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That is not a scalp dosage. Its a dose for hairs that were removed from a scalp via a biopsy.
 
Murkey Thumb

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Its not Cyclosporine A but a synthesised version with a better safety profile so shouldn't mess with you immune system or give you cancer. Although it will take 5 years of safety profiling before we actually know.
 
Arrade

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Eren said:
Ridiculous indeed, but that guy went full retard and feminized himself. For most men, that is not a viable option. His description under his YouTube film says it all.

"Hair loss and bald is disaster I got from my father and my mother. I can not angry or claim money for treatment from them. They said "this problem is not their responsibility". --- 2008, I got money from parents for "carnivore man" style treatment. But it was a failed. 2009 until now, I handle my trememt budget with my own money for "herbivore man" style. --- Thanks to an old couple. She accelerated me to the dark side. I HRT like ladyboys. The result is "I am not bald". Finally, I gave a task to a ladyboy for divorce our relationship. And my life was restarted again. --- Although I meet people by pure heart . But I swear, I would not give any children born with my bald blood."
Click to expand...
What a loser. also He'll never be able to have children, thank goodness
 
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