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DHT is biologically important for
sexual differentiation of the
male genitalia during
embryogenesis, maturation of the penis and scrotum at
puberty,
growth of
facial,
body, and
pubic hair, and development and maintenance of the prostate gland and seminal vesicles. It is produced from the less potent testosterone by the
enzyme 5α-reductase in select tissues, and is the primary androgen in the genitals, prostate gland, seminal vesicles, skin, and hair follicles.
[2]
DHT signals mainly in an
intracrine and
paracrine manner in the tissues in which it is produced, playing only a minor role, if any, as a circulating
endocrine hormone.
[3][4][5] Circulating levels of DHT are 1/10th and 1/20th those of testosterone in terms of total and free concentrations, respectively,
[6] whereas local DHT levels may be up to 10 times those of testosterone in tissues with high 5α-reductase expression such as the prostate gland.
[7] In addition, unlike testosterone, DHT is inactivated by
3α-hydroxysteroid dehydrogenase (3α-HSD) into the very weak androgen
3α-androstanediol in various
tissues such as
muscle,
adipose, and
liver among others,
[5][8][9] and in relation to this, DHT has been reported to be a very poor
anabolic agent when administered exogenously as a medication. (source:
https://en.wikipedia.org/wiki/Dihydrotestosterone)