spironolactone & Finasteride cream

[guybrush]

Hi guys!

After discontinuation of finasteride I'm considering to crush some proscar pills and incorporate the powder into Dr. Lee's spironolactone cream using some propylene glycol.

What do you guys think of this?

I believe the combination of an androgen blocker and an antiandrogen can make the trick (in case finasteride really makes it to the follicle). There's a study showing the synergistic effect of topical spironolactone along with several antiandrogens at very low concentrations:

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

At the moment I'm using spironolactone 2% liquid with 0,025% Finasteride but I believe the cream will rest in the scalp for longer thus providing better results.

BTW there's at least one study showing that finasteride cream can have some effect as DHT inhibitor:

http://www.ncbi.nlm.nih.gov/pubmed/...med_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

Any opinion/suggestion will be welcomed

Thanks!

 

[baller234]

That's an interesting study. Seems like a topical cream of progesterone, spironolactone, and finasteride would be ideal. How do you plan on getting your finasteride tablets to effectively dissolve into the spironolactone cream?

 

[guybrush]

I used 2ml of alcohol but it made the cream lose a bit of its consistency. I would say it's better to just add the powder into the cream, it will disolve well.

 

[azyx]

I think its better to dissolve the tabs in small amount of propylene glycol, its more thick than ethanol! If you put the powder of crushed tabs directly into the spironolactone they will not dissolve as good!

 

[guybrush]

Yeah, you might be right. That's what I planned to do but I was too lazy to go for a bottle of PPG so I used alcohol. :whistle: