Spironolactone stronger than RU58841? (77 nM vs. 100nM)

[AndrewBarnes]

Straight males shouldn't be taking oral spironolactone at all let alone 100-150mg

 

[real kombo]

Straight males shouldn't be taking oral spironolactone at all let alone 100-150mg

Well I mean, can you explain why? I am not necessarily opposed to mild feminization (softer, less oily skin, more hair, lower libido, etc) if it means significant hair growth. Surely such a dose in and of itself wont cause full feminization, as transgendered individuals usually take it along with estrogen and host of other drugs.

I guess I'm just looking for a more substantive rebuttal on why it shouldn't be taken under any circumstances by a male with high testosterone.

 

[coco_304]

People usually tout what they like best and I would put medroxyprogesterone acetate at the top of the list if we are not talking oral minoxidil. I have had no sides that I can tell from MPA or provera (brand name). If you are going to do this scientifically, you probably should test if possible. My current quest is to try to verify the effects of middling amounts of T and E2 on hair improvement.

What is provera, what is used for..

 

[JaneyElizabeth]

What is provera, what is used for..

Medroxyprogesterone Acetate, also known as provera and as depo-provera when injected, is a straightfoward T-lowering medication that for me, at least, lacked sides completely. For MtF's it might help complete breast growth along with P4 but we lack data. I take it and progesterone but I was already kind of busty but my nipples seem to be getting larger now and I am in my 8th year since I started using Life-Flow Biestro.

 

[coco_304]

Its like cpa?
its reduce testosterone and estrogen?

 

[JaneyElizabeth]

Well I mean, can you explain why? I am not necessarily opposed to mild feminization (softer, less oily skin, more hair, lower libido, etc) if it means significant hair growth. Surely such a dose in and of itself wont cause full feminization, as transgendered individuals usually take it along with estrogen and host of other drugs.

I guess I'm just looking for a more substantive rebuttal on why it shouldn't be taken under any circumstances by a male with high testosterone.

What a minute. What does being straight have to do with it? Straight is a term that to MtF's has no meaning anyway. We technically are either gynephilic or androphilic.

 

[JaneyElizabeth]

Its like cpa?
its reduce testosterone and estrogen?

Chemically, it is very close to CPA and often goes by the similar, MPA. They are both progestins but they work very differently. Technically, MPA, Duta, finasteride, CPA, Bica and spironolactone are all AA's. But in general HRT usage, only spironolactone, CPA and Bica are AA's. What this means is that they tend to spoof higher estrogen and more so lower testosterone but they still keep circulating but without receptors since CPA, Bica and spironolactone block androgens from their receptor sites. MPA just lowers T without occupying receptors. I have used MPA, P4 and spironolactone and spironolactone just feels weird while P4 and MPA don't really have a feeling to them nor at least in my case, any noticeable sides.

 

[coco_304]

how much to take provera to reduce testosterone?

 

[coco_304]

I know cpa reduce both testosterone and estorgen, provera reduce just testosterone,
How it do this?

 

[JaneyElizabeth]

I know cpa reduce both testosterone and estorgen, provera reduce just testosterone,
How it do this?

I am bright but I am no chemist MPA is usually prescribed at 2.5mg, 5mg and 10 mg for HRT. At these levels only moderate amounts of T are lowered. At 80mg, most T is eradicated so there is a dosing curve. Both CPA and MPA in doses above 80mg can be used for sexual offenders in some places for release or early release. They don't use estrogen probably for the reason that most guys on here prefer AA's. Males freak out about estrogen even if AA's are in many ways more feminizing.

 

[coco_304]

what is contribute of p4 to hairloss..?

 

[coco_304]

I am bright but I am no chemist MPA is usually prescribed at 2.5mg, 5mg and 10 mg for HRT. At these levels only moderate amounts of T are lowered. At 80mg, most T is eradicated so there is a dosing curve. Both CPA and MPA in doses above 80mg can be used for sexual offenders in some places for release or early release. They don't use estrogen probably for the reason that most guys on here prefer AA's. Males freak out about estrogen even if AA's are in many ways more feminizing.Are you

I am bright but I am no chemist MPA is usually prescribed at 2.5mg, 5mg and 10 mg for HRT. At these levels only moderate amounts of T are lowered. At 80mg, most T is eradicated so there is a dosing curve. Both CPA and MPA in doses above 80mg can be used for sexual offenders in some places for release or early release. They don't use estrogen probably for the reason that most guys on here prefer AA's. Males freak out about estrogen even if AA's are in many ways more feminizing.

What is you sex if its ok to ask?

 

[JaneyElizabeth]

what is contribute of p4 to hairloss..?

Probably little to none but some claim that it might help. I cycle P4 or progesterone, ten days per month as does KCMB and @bridegeburn, at 300 mg nightly. My feeling is that P4 is worth a shot for MtF's for breast development and it might have mild hair effects but generally is not considered a hair loss palliative.

 

[coco_304]

Probably little to none but some claim that it might help. I cycle P4 or progesterone, ten days per month as does KCMB and @bridegeburn, at 300 mg nightly. My feeling is that P4 is worth a shot for MtF's for breast development and it might have mild hair effects but generally is not considered a hair loss palliative.

You are really brilliant

 

[JaneyElizabeth]

You are really brilliant

That's nice of you to say. Honestly since I went on MtF HRT, I sleep much less and if anything, I feel smarter somehow but it might have more to do with focus. Thank you for the compliment.

 

[JaneyElizabeth]

What is you sex if its ok to ask?

I didn't see this before. I am MtF. I only started transitioning in my 50's and I am now 56. Since I have been having such exciting results, I started posting in October and I post every week to three or so here:

https://www.hairlosstalk.com/interact/threads/hair-is-not-life-but-its-pretty-damn-close-hrt-and-pictorial-posts-prove-it.130425/page-23

My goal is that people can see what an estrogen-recovery looks like, at least in one case. My thought is that regrowth occurs in a female context so that can be confusing, meaning all of the hair improves even the hair that is not balding. These are probably anagen-effects but they differ some in that the hair shaft improves in sheen, texture and manageability including growing longer.

You can also ask questions there and I write about topics that are of interest to me and hopefully the hair loss community on this thread. I hope you will feel free to participate.

 

[coco_304]

I didn't see this before. I am MtF. I only started transitioning in my 50's and I am now 56. Since I have been having such exciting results, I started posting in October and I post every week to three or so here:

https://www.hairlosstalk.com/interact/threads/hair-is-not-life-but-its-pretty-damn-close-hrt-and-pictorial-posts-prove-it.130425/page-23

My goal is that people can see what an estrogen-recovery looks like, at least in one case. My thought is that regrowth occurs in a female context so that can be confusing, meaning all of the hair improves even the hair that is not balding. These are probably anagen-effects but they differ some in that the hair shaft improves in sheen, texture and manageability including growing longer.

You can also ask questions there and I write about topics that are of interest to me and hopefully the hair loss community on this thread. I hope you will feel free to participate.

What is your regime for hairloss only..?

 

[JaneyElizabeth]

What is your regime for hairloss only..?

For me or for cis-guys?

For me:
MPA 10 mg
Duta .5mg
Estrogel I use freely in enormous amounts
Estradiol 2XClimara 100's
Premarin 1.25 mg daily
Keto (rarely since MtF's don't have to wash our hair really ever
Topical Min
Oral Min 12.5 mg daily
Progesterone (Prometrium) Cycle ten days per month at 300 mg for ten nights. It is a soporific so most take at night.

I am probably forgetting something but this is essentially the most aggressive hair loss regime that I know of, especially given that I eschew the big 3 AA's. I post my regime and the two main ones of @bridgeburn
frequently on my thread. His were ultra-aggressive too and he always used AA's.

My regime will take a person likely to first trimester pregnancy levels of estradiol which is way too much for maintenance but I am testing whether it helps even more with hair loss since females tend to have great hair during pregnancy. Their main estrogens do change though which I don't do because then you need estriol and estrone on hand and it isn't likely to make a difference. I am also going for even more facial feminization and it seems to be helping there. Being an MtF is fascinating scientifically.

 

[coco_304]

What is your regime

For me or for cis-guys?

For me:
MPA 10 mg
Duta .5mg
Estrogel I use freely in enormous amounts
Estradiol 2XClimara 100's
Premarin 1.25 mg daily
Keto (rarely since MtF's don't have to wash our hair really ever
Topical Min
Oral Min 12.5 mg daily
Progesterone (Prometrium) Cycle ten days per month at 300 mg for ten nights. It is a soporific so most take at night.

I am probably forgetting something but this is essentially the most aggressive hair loss regime that I know of, especially given that I eschew the big 3 AA's. I post my regime and the two main ones of @bridgeburn
frequently on my thread. His were ultra-aggressive too and he always used AA's.

My regime will take a person likely to first trimester pregnancy levels of estradiol which is way too much for maintenance but I am testing whether it helps even more with hair loss since females tend to have great hair during pregnancy. Their main estrogens do change though which I don't do because then you need estriol and estrone on hand and it isn't likely to make a difference. I am also going for even more facial feminization and it seems to be helping there. Being an MtF is fascinating scientifically.

How do you take Premarin, orally ?