how do you explain the fact that 2.5mg/day dutasteride regrows more hair than 0.5mg/day dutasteride, and lower doses of finasteride that inhibit less than 40% of type 2 don't seem to have much effect on hair loss.
Bryan, do you know how much DHT 0.05mg/day and 0.2mg/day inhibit? You posted a graph, but it contradicted a different graph I once saw.
Anyway, with the dutasteride at least, I wonder if the extra 1.3% inhibition of type 2 explains the larger regrowth, or if the extra type 1 inhibited explains it.
Either way, I wonder if there are any tests to show if testosterone can hurt follicles at normal biologic levels, in the absence of 5ar2, so we know the DHT did not do it. The people who are deficient in 5ar2 don't loose hair, but still have testosterone.
The castrated men don't have much testosterone, and did not lose or regrow hair. Too bad we did not have cameras count their hair. We don't know if they did grow more hair than dutasteride would give them, and just not see it because it was too gradual or too small. But this does make me wonder if the testosterone is benificial, and the DHT harmful. Just looking for some kind of study.
Anyway, the fact that they kept their 14 year old hair lines would suggest that maybe dutasteride would not have the same post two year decline that propecia has. I still think spironolactone may be good, since testosterone levels are raised above normal levels with dutasteride in the scalp. But I'm wondering if reducing testosterone below normal levels is good.
We lump all adrogens together, but I'm not convinced every androgen has the same effect on the androgen receptor. We already know that RU58841, which has a strong affinity for it, has no effect on it, at least with what we are measuring.
Bryan, do you know how much DHT 0.05mg/day and 0.2mg/day inhibit? You posted a graph, but it contradicted a different graph I once saw.
Anyway, with the dutasteride at least, I wonder if the extra 1.3% inhibition of type 2 explains the larger regrowth, or if the extra type 1 inhibited explains it.
Either way, I wonder if there are any tests to show if testosterone can hurt follicles at normal biologic levels, in the absence of 5ar2, so we know the DHT did not do it. The people who are deficient in 5ar2 don't loose hair, but still have testosterone.
The castrated men don't have much testosterone, and did not lose or regrow hair. Too bad we did not have cameras count their hair. We don't know if they did grow more hair than dutasteride would give them, and just not see it because it was too gradual or too small. But this does make me wonder if the testosterone is benificial, and the DHT harmful. Just looking for some kind of study.
Anyway, the fact that they kept their 14 year old hair lines would suggest that maybe dutasteride would not have the same post two year decline that propecia has. I still think spironolactone may be good, since testosterone levels are raised above normal levels with dutasteride in the scalp. But I'm wondering if reducing testosterone below normal levels is good.
We lump all adrogens together, but I'm not convinced every androgen has the same effect on the androgen receptor. We already know that RU58841, which has a strong affinity for it, has no effect on it, at least with what we are measuring.