Study: Licorice, peppermint DECREASE sebum secretion

[CCS]

http://www.easycart.net/cgi-bin/BeyondA ... search.cgi

LICORICE, DGL. Deglycyrrhizinated licorice std. powder (<3% glycrrhizinic acid), used for centuries to protect from peptic and gastric ulcers by increasing prostaglandins which protect the stomach lining. Soothing to the stomach.** DGL must be “chewedâ€￾ (mixed with saliva) to be effective. Sweet taste. 100 grams, $5.90.

I wish I knew if it was the glycrrhizinic acid that is the good stuff, or if it is something else.

 

[CCS]

the three glycyrrhizin-producing species (i.e. G. glabra, G. uralensis, G. inflata)
it is a saponin. not sure if that is what does the stuff we want though.

http://www.jstage.jst.go.jp/article/bpb/28/1/161/_pdf

http://www.iupac.org/publications/pac/2 ... 7x1199.pdf

glabra may be as good as inflata

http://en.wikipedia.org/wiki/Licorice

http://en.wikipedia.org/wiki/Deglycyrrh ... d_licorice

http://en.wikipedia.org/wiki/American_Licorice

only black licorice is licorice. The red vines are just a raspberry flavored candy that looks the same. So nice to know that there is not a big red/black difference. Maybe they are very similar, these species.


chinese licorice seems to do the same thing as the american licorice: Licorice or gancao are roots that have an extremely sweet taste but is a little bitter and are said to neutralize toxins, relieve inflammation, and enhance digestion. The use of licorice is to treat hepatitis, sore throat, and muscle spasms. When licorice is baked with honey it can also help in the treatment of hyperthyroidism and heart valve diseases.


http://en.wikipedia.org/wiki/Glycyrrhiza
http://en.wikipedia.org/wiki/Glycyrrhizin

 

[squeegee]

The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3 alpha- and 3 beta-hydroxysteroid dehydrogenases and 5 alpha- and 5 beta-reductase pathways of metabolism of aldosterone in male rats.

Ingestion of licorice or treatment with chemical derivatives of glycyrrhetinic acid (GA), an active principle of licorice, can cause hypertension, sodium retention, and hypokalemia. Although GA has been shown to inhibit 11 beta-hydroxysteroid dehydrogenase, it may not be the only hepatic enzyme affected by this licorice derivative. Therefore, we studied the effects of GA on other major hepatic steroid-metabolizing enzymes from adrenalectomized male rats using aldosterone as the substrate; namely, delta 4-5 alpha- and delta 4-5 beta-reductases and 3 alpha- and 3 beta-hydroxysteroid dehydrogenases (3 alpha- and 3 beta-HSD). From these in vitro studies, we demonstrated that GA does not affect either microsomal 5 alpha-reductase or cytosolic 3 alpha-HSD activity. However, GA is a potent inhibitor of cytosolic 5 beta-reductase; the K(is) and K(ii) were calculated from enzyme kinetic analysis to be 6.79 and 5.41 microM, respectively, using the Cleland equation, indicating that GA is a noncompetitive inhibitor of aldosterone. In addition, GA specifically inhibited microsomal 3 beta-HSD enzyme activity by what appears to be a competitive inhibition mechanism, causing a build-up of the intermediate, 5 alpha-dihydroaldosterone (DHAldo). Thus, this study has indicated that GA has a profound effect on hepatic ring A-reduction of aldosterone. Inhibition of 5 beta-reductase and 3 beta-HSD results in decreased synthesis of both 3 alpha, 5 beta-tetrahydroaldosterone (THAldo) and 3 beta, 5 alpha-THAldo and, hence, accumulation of aldosterone and 5 alpha-DHAldo, both potent mineralocorticoids.


Ok lot of blabla but I think a got my answer: Inhibition of PKC activity was nearly 100% with glycyrrhetinic acid glycoside (glycyrrhizine) at 200 ?M; and 52% with 18/5- glycyrrhetinic acid at 500 ?M.


http://www.wipo.int/pctdb/en/wo.jsp?WO= ... SPLAY=DESC INHIBITION OF HAIR GROWTH

Glycyrrhetinic acid is the major active component..It is what we want so far...from the Licorice root. unk:

 

[CCS]

http://www.botanical.com/botanical/mgmh ... 2.html#des

http://www.stevenfoster.com/education/m ... orice.html

 

[CCS]

Glycyrrhetinic acid is the major active component..It is what we want so far...from the Licorice root. unk:

And there are 3 species that have it. Inflata is one of them, and the other licorice we've been finding is another.

It ranges from 5-24% of the mass of the root, and is what makes it sweet. That $5.90 100g stuff I found is less than 3%, but...

 

[CCS]

edit. squeege found something better.

 

[squeegee]

The amount of Glycyrrhizin present in Extract of Liquorice varies from 5 to 24 per cent, and the amount of moisture from 8 to 17 per cent. Upon ignition, the extract yields from 5 to 9 per cent of ash.


http://www.herbalextractsplus.com/licorice.cfm This place we can buy bulk powder Standardized Extract (20% Glycyrrhizic Acid)

?????????What do you think?

Glycyrrhizic Acid is the key ingredient so far..I think

 

[CCS]

http://www.google.com/search?client=fir ... gle+Search
yes, that is, and check out these shampoos with that ingredient.

 

[squeegee]

http://www.satveda.com/product.asp?pID=87&cID=4&c=31828 Is it from the Root???

 

[CCS]

The amount of Glycyrrhizin present in Extract of Liquorice varies from 5 to 24 per cent, and the amount of moisture from 8 to 17 per cent. Upon ignition, the extract yields from 5 to 9 per cent of ash.


http://www.herbalextractsplus.com/licorice.cfm This place we can buy bulk powder Standardized Extract (20% Glycyrrhizic Acid)

?????????What do you think?

Glycyrrhizic Acid is the key ingredient so far..I think

WOW. good find. Get the 1/4 pounder for $17. Put a gram or two in each of your shampoos. 1/4 pound = 110 grams. You just saved a lot of money. I also bought 4oz of peppermint oil and 4oz of lavender oil on amazon for a total of $27 after shipping. That should last me a long time.

 

[squeegee]

So much good stuff! Going to try those shampoos !!I f*****g dig LICORICE CCS!!!

 

[squeegee]

With 4oz of Peppermint and Lavender you are good to go!I paid 10 $ for 30 ML for each @ a stupid Natural supp. Store. I like this stuff...But have to try the Licorice too.. I hate topical applications but those ones don't bother me at all..Probably the smell of Licorice would be something different!

 

[CCS]

I'll cover it with peppermint if I don't like it.

And I'm using this on my face too. Bye bye big pores. They are big because they are full of crap, probably over active because of androgens. And bye bye redness.

 

[squeegee]

Licorice contains one compound that prevents the conversion of testosterone to DHT. You could prepare a baldness-prevention shampoo by adding licorice to you favorite shampoo when you shower.


http://www.tomsgroupcruises.com/licorice.html WTF????

 

[CCS]

I just placed my order. Shipping was $5.

THANK YOU SQUEEGEE!!!

 

[squeegee]

Already! CCS you are a crazy MOFO Guinea pig!I will follow you really shortly lol!

 

[squeegee]

By the way CCS It is f*****g team WORK.. unk:

We are not done yet..only the beginning!

 

[CCS]

yeah, i want to look up the ingredients to that shampoo that stopped sebum production. maybe the vehicle matters for propper absorption.

 

[IBM]

CCS topicals are big waste of time. I've seen only one or two cases of success.

Did you got anywhere with RU? No.

Anyway some people dont need testosterone to impress girls. They prefer hair instead.

 

[Jacobo]

If the study MB posted claims that Licorice was the best performing oil, why is peppermint oil so highly discussed in this thread? MB or Bryan, would you recommend purchasing a shampoo with Glycyrrhiza in the ingredients? This is the active ingredient in Licorice and there are many shampoo's available with this ingredient. Just google "Glycyrrhiza & shampoo" and you will find many alteratives. Like this for example: http://www.lamasbeauty.com/chinese.html

MB - I read your recent post pertaining to your concern over using peppermint oil on your scalp. Based on your previous advice I have been using a peppermint based shampoo. Can you please elaborate on why you are now concerned about the peppermint efficacy?

You can check this thread viewtopic.php?f=32&t=42134&hilit=curcumin+angiogenesis

But then, this is is a quote from Doc077 in this very thread:

The only people that need to worry about angiogenesis inhibition are those with any type of organ ischemia. Especially, the heart. I could foresee far worse outcomes when it comes to the skin for those who focus on upregulating angiogenesis as a hair loss treatment

We are going to end probably bald, and definitely insane.