Taurine With Minoxidil And Sult1a1 Enzyme

[Xander94]

Taurine and glycine increase salicylic acid.

My understanding glycine excretes salicylic acid and forms salicyluric acid.

pick only 1

 

[Kaus Klinski]

Hmm, well, but what does the intrahepatic SULT1A1 have to do with the SULT1A1 expressed in the scalp? OK, I get that for oral minoxidil, but I still don't understand what role aspirin plays? Why would anybody take aspirin in the first place (except for antiplatelet aggregation)? It's an obsolete drug for pain/inflammation with the highest risk of stomach issues and the lowest effectiveness compared to other NSAIDS.

regards
Kaus Klinski

 

[Xander94]

Where did this guy read about taurine creating salicylic acid ?

THis post is bullshit I cant find a single source stating this.

Infact taurine might even help REMOVE it from the body just like glycine

 

[Warmer82]

pick only 1

Salicylic acid undergoes further metabolism in the liver and kidney. Cytochrome p-450 enzyme system in mitochondria is capable of catalyzing salicylate into different metabolites such as 2,3,5-trihydroxy benzoic acid, 2,5-dihydroxy benzoic acid, and catechol. Salicylic acid is readily available for the conjugation reaction with glycine to form salicyluric acid or D-glucuronic acid and form salicylacyl glucuronide or 1-salicylate glucuronide via the formation of ether or ester bonds [42]. Salicylic acid has recognized antipyretic and antiinflammatory properties that underlie the use of willow bark for fever and arthritis. Acetylsalicylic acid (aspirin) is a synthetic derivative of salicylic acid that in addition has pronounced antiplatelet properties due to the presence of the acetyl group [43].

 

[Kaus Klinski]

I still don't get what saliyclic acid has to do with taurine/SULT1A1 and minoxidil efficacy ...

 

[Xander94]

I still don't get what saliyclic acid has to do with taurine/SULT1A1 and minoxidil efficacy ...

I don't think the guy who made the thread understands either

 

[transam]

I don't think the guy who made the thread understands either

If any of this was a big deal, there'd be a warning on Rogaine/Minoxidil saying please dont take over-the-counter asprin while minoxidil is applied on your scalp.

 

[Kaus Klinski]

The question is, why would anybody take aspirin in the first place? It's an obsolete drug for pain/inflammation and causes more harm than good.

 

[getting_back]

https://www.ncbi.nlm.nih.gov/m/pubmed/30226287/

Aspirin effects Min efficiency. Took 1g daily for 6 months and definitely saw a lot of shedding.

 

[getting_back]

The question is, why would anybody take aspirin in the first place? It's an obsolete drug for pain/inflammation and causes more harm than good.

Heart inflammation for example

 

[Kaus Klinski]

1 Gram of Aspirin per day for 6 months is a recipe for stomach issues. Bad idea. Why did you take such a relatively high dose for so long? If you want an anti platelet effect, not more than 50 - 100 mg/day is required. That's the only indiciation for (low dose) Aspirin. It's obsolete as a pain killer. Not only isn't it as effective as the newer nsaids, it's the hardest nsaid on the stomach due to the irreversible cox1 inhibition.

Regards
Kaus Klinski

 

[Kaus Klinski]

Heart inflammation for example

Why would Aspirin be useful to treat myocarditis, except for perhaps its anti platelet action (which requires only a very low dose)?

Regards
Kaus Klinski

 

[getting_back]

Why would Aspirin be useful to treat myocarditis, except for perhaps its anti platelet action (which requires only a very low dose)?

Regards
Kaus Klinski

Was diagnosed with Perimyokarditis one year ago. It wasn't viral nor caused by bacteria. And this was the preferred treatment.. I took also medication to protect my stomach alongside with colchicine.

 

[getting_back]

Still on minoxidil... Not sure if this is good

 

[Kaus Klinski]

I took also medication to protect my stomach

Good idea. What did you take, a PPI? Keep in mind that PPi drugs taken longterm, especially in higher doses, can deplete the body of certain micronutrients, like zinc, B12, Iron, Magnesium and Calcium.

Regards
Kaus Klinski

 

[Kaus Klinski]

till on minoxidil... Not sure if this is good

Why shouldn't it "be good"? It's one of the only few proven treatments.

Regards
Kaus Klinski

 

[Obsessive]

Im on oral minoxidil 1.25mg, been on this from december. I tried taurine 3g two months later daily,although it helps with sides from minoxidil, but i noticed shedding around a week later. I stopped taurine and within a week i stopped shedding, ive tried taurine again and now shedding yet again.

Now I've been doing some research on taurine and minoxidil so below is what i think

Minoxidil gets converted by an enzyme called sult1a1 to minoxidil sulfate without this enzyme users don't get any results.
Taurine is a sult1a1 inhibitor, so by inhibiting sult1a1 enzyme, minoxidil cannot convert into minoxidil sulfate by sulfotransferase by the sult1a1 enzyme. This must explain why my hair is shedding around a week after i take taurine.

Any thoughts from any users who use both??

Interesting-I started taurine since i was using oral min. I've dropped oral for topical so if taurine really does downregulate sult1a1, especially in the scalp, I should take a break and see what happens.

 

[Kaus Klinski]

I still don't see the link between taurine and aspirine and how it's supposed to affect SULT1A1 ...

 

[Xander94]

bros stop giving this sh*t visibility its some stupid person imagining sheddings and blaming it on taurine

 

[Kaus Klinski]

Maybe the mentioned person could conclude this thread and eventually give us some enlightenment?