The Cb (breezula [clascoterone]) Community Thread
- Thread starter Screeech
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- Reaction score
- 614
Still above baseline after 12 months but all gains are lost. Such a weak AA it's barely worth the effort of applying every day, let alone twice a day.
Let's compare that now to how finasteride performs versus placebo. Finasteride continues to improve versus placebo for five years whereas Breezula can only do this for 6 months. I seriously question whether CB upregulates the AR making you more sensitive to DHT over time.
Ok so I saw that graft you posted after I posted my reply. On the graft of propecia it looks like growth peaks at around a year before slightly dropping off, CB's graft peaks growth at around month 6 before significantly dropping off. I agree that it could be upregulation but the body usually balances out after a while which could happen after a year we don't know of course.
I don't think CB will be a stand alone treatment honestly, and I think if CB isn't effective enough more pharma companies may try to compete with other drugs using the same mechanism of action which would be great but that's far down the line obviously.
I don't think CB will be a stand alone treatment honestly, and I think if CB isn't effective enough more pharma companies may try to compete with other drugs using the same mechanism of action which would be great but that's far down the line obviously.
- Reaction score
- 1,335
Upregulating AR with Fina takes a decade. If CB does it in 6 months that's incredibly unlucky.
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- 70
Any chance that CB continues to give maintenance or do you think it will keep falling
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- 213
if cb does cause AR upregulaion overtime could this be solved by upping the dosage in a similar way that RU user have to do overtime due to the same upregulation , and since CB is supposed to be " side effect" free the only drowback would be the price? Sry for that question i'm retarded but seems like a better alternative to finasteride for those who can't handle it ( btw i'm not a finasteride fearmongering i've been using finasteride and dutasteride for 5 years with no results)
I mean you’re not wrong. Antagonist drugs are known to cause hypersensitivity to the receptors they bind to, but who knows I guess we will see the stats of the next trial.
- Reaction score
- 70
Would you recommend I start with .05 finasteride or breezula?
We don’t know. We need a longer trial and more data.
Yes as I said before it can balance out naturally but we don't know yet.
And in theory you could just take more until all the receptors are filled unless for some reason CB has a ceiling dose or starts to give sides.
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- 1,335
At 7.5% twice daily (the one that provided best results) to boot with, I suppose it could be very expensive to think this is long term. I can't imagine they bring a lotion to the market that works for ,6 months only.
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- 70
Would you recommend I start with .05 finasteride EOD or breezula with needling?
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- 1,335
Fina. Don't bother with CB. It's crap.
Have you tried it?
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- 70
Is microdosing (.5mg eod) or topical finasteride (.1%) better for reducing sides?
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- 1,335
I suppose but I never understood sides .with low dosage. They are sides but at a much higher dosage. And since they can be reversed you can start at normal dose and lower if you are becoming important since it goes back to square one when you stop.
- Reaction score
- 70
Do you get sides? Also should I do oral instead of topical? I assume you dong have confidence in zix either right