The Cb (breezula [clascoterone]) Community Thread

[Dimitri001]

I contacted the same vendor they said 2300 USD for 100 grams I would be interested in a group buy if one of us gets a sample tested.

Now, wait a minute. 245 for 10 grams and 2300 for 100??? So they knock the price down for only 1.5 USD/g if you buy 10x? We need to do some more asking around.

Yeah, we'll definitely test the stuff.

Anyway, I'll add you to the list, Jim.

Any other takers?

Less than $7/day. Unfortunately cb just isn't worth it as far as efficacy goes. The only selling point is no sides, which most people don't get serious sides from RU or finasteride which are both more effective and substantially cheaper.

It would be worth it if we can find a way to resolve the AR upregulation problem, which I'm hoping we'll find a way to do, whether with cycling or some other means.

I don't think finasteride is more effective. From the TAHC numbers I've seen, CB does at 6 months what finasteride does at a year. Of course, there's the 6 months cliff problem...

As far as sides, sides with finasteride may be rare, but I don't want to take the chance that I'll be of the few who get gyno and PFS is devastating enough that, no matter how rare it is, I would want to avoid the potential of it happening.

 

[Jim lahey]

If there even is an upregulation problem.

 

[sonictemples]

The chance of dying in a car accident is greater than the risk of getting pfs. That's far more devastating, but it doesn't prevent you from driving. There's too much fear over finasteride.

Do we have statistics on that

 

[Dimitri001]

If there even is an upregulation problem.

My understanding is that that seems like the likely explanation, but yes, it may be something else.

The chance of dying in a car accident is greater than the risk of getting pfs. That's far more devastating, but it doesn't prevent you from driving. There's too much fear over finasteride.

Yes, but I have to drive, I don't have to take finasteride. It's more the gyno that I'm worried about, tho. I know the odds of that are probably slim, too, but again, that's so awful I don't even want to take very slim odds.

 

[Dimitri001]

Upregulation is probably highly individual, depending on your genetic make up.

You have some people on antidepressants who've been doing fine on the same antidepressant for over 20 years, without any dose adjustments! And you have others who are one year on a certain antidepressant and witness poop-out / rapid tolerance build-up / effect-loss.

Is upregulation permanent or would it go away after you stopped blocking the ARs for a while?

Did Cassiopea & Intrepid Therapeutics comment on that effect loss after x months?

That's what I wanna know, too. AFAIK, no. I haven't seen them mention it in any of their documents (not that I've read all of them). They pretty much take a triumphant stance with regards to phase II results, as though there's no problem.

I don't know what their thinking is, though, as the fact will inevitably out once CB hits the market. Maybe they're just bluffing for time to figure it out.

I've sent them an email about it that I expect them to ignore.

 

[corkmeister]

Is upregulation permanent or would it go away after you stopped blocking the ARs for a while?



That's what I wanna know, too. AFAIK, no. I haven't seen them mention it in any of their documents (not that I've read all of them). They pretty much take a triumphant stance with regards to phase II results, as though there's no problem.

I don't know what their thinking is, though, as the fact will inevitably out once CB hits the market. Maybe they're just bluffing for time to figure it out.

I've sent them an email about it that I expect them to ignore.

This may just be me being cynical, but at this point I fully expect them to never mention the one year drop-off again as they just bring it to market.

 

[telogen]

It would be worth it if we can find a way to resolve the AR upregulation problem, which I'm hoping we'll find a way to do, whether with cycling or some other means.

It would be interesting knowing how much ASC-J9 may help in downregulating the AR.

 

[Jim lahey]

TAHC isn't really the best method to see if the drugs working or not, looking at what the actual follicle is doing is much better. If the follicle starts to shrink similar to the results of the TAHC then upregulation would obviously be the leading theory to the diminished returns. Either way both measures are still above baseline at 12 months which = maintenance which is all we ever expected from this drug.

 

[Leauxi]

How long roughly would 10 grams of CB last?

 

[Jim lahey]

2-3 months depending how you use it

 

[Throwaway94]

How long roughly would 10 grams of CB last?

Just over a month if you replicate the study (75mg/ml * 2mL * 2 applications per day) ends up 300mg/day. 33 days with 10g.

 

[Dimitri001]

If you can't afford the best performing dose (7.5% 2x a day), then go with 2.5% 2x a day - it's the least CB used and it gives the same results as the next highest does after 7.5% 2x.

Just over a month if you replicate the study (75mg/ml * 2mL * 2 applications per day) ends up 300mg/day. 33 days with 10g.

Would it be reasonable to expect that if you used 75mg/ml, but only 1ml and applied it 2x a day in your bald areas you'd get the same results in that area as they got in the target area (that they measured the TAHC in) with 2ml?

In other words, is it the concentration or the quantity?

Presumably they didn't use the 2ml just on the target area that they measured TAHC in, meaning you don't necessarily need 2 ml to get the same results.

TAHC isn't really the best method to see if the drugs working or not, looking at what the actual follicle is doing is much better. If the follicle starts to shrink similar to the results of the TAHC then upregulation would obviously be the leading theory to the diminished returns.

I'm not quite following you here, what do you mean? Are you saying it's ok if the new hairs are falling of so long as the ones you had at baseline aren't miniaturizing?

Either way both measures are still above baseline at 12 months which = maintenance which is all we ever expected from this drug.

But after 6 months it goes down at a faster rate than the vehicle group and we only have data for 12 months, who knows what happened after that. If AR upregulation happened, they might have continued to lose ground faster than the control group.

 

[Leauxi]

I'd be keen to jump in on that group buy if you guys are still planning on doing it

 

[Dimitri001]

I'd be keen to jump in on that group buy if you guys are still planning on doing it

Yes, I'll add you to the list.

And if you guys know anyone who might wanna get on, go ahead and evangelize.

 

[Jim lahey]

If you can't afford the best performing dose (7.5% 2x a day), then go with 2.5% 2x a day - it's the least CB used and it gives the same results as the next highest does after 7.5% 2x.



Would it be reasonable to expect that if you used 75mg/ml, but only 1ml and applied it 2x a day in your bald areas you'd get the same results in that area as they got in the target area (that they measured the TAHC in) with 2ml?

In other words, is it the concentration or the quantity?

Presumably they didn't use the 2ml just on the target area that they measured TAHC in, meaning you don't necessarily need 2 ml to get the same results.



I'm not quite following you here, what do you mean? Are you saying it's ok if the new hairs are falling of so long as the ones you had at baseline aren't miniaturizing?



But after 6 months it goes down at a faster rate than the vehicle group and we only have data for 12 months, who knows what happened after that. If AR upregulation happened, they might have continued to lose ground faster than the control group.

There are no new hairs all of them pretty much are hairs you had before taking the drug. I'm saying that looking at if the follicles themselves are miniaturizing or not is a better study.

 

[sonictemples]

Yes, I'll add you to the list.

And if you guys know anyone who might wanna get on, go ahead and evangelize.

What is the gram price

 

[Dimitri001]

What is the gram price

The offers we've had are 245 USD for 10g and 2300 USD for 100 grams, but I think we ought to be able to talk them down more if we go 100 grams. Also, I'll ask for a price from a whole bunch of sellers, so maybe we can find something better, although this is already quite good.

Should I put you on the list?

 

[sunlight2]

Hi there, I would be interested in this group buy too...is it possible to still get on the list?

 

[Dimitri001]

Hi there, I would be interested in this group buy too...is it possible to still get on the list?

You're in!

Yes, of course, we're very much looking for members. Tell all your friends about it!

 

[sonictemples]

The offers we've had are 245 USD for 10g and 2300 USD for 100 grams, but I think we ought to be able to talk them down more if we go 100 grams. Also, I'll ask for a price from a whole bunch of sellers, so maybe we can find something better, although this is already quite good.

Should I put you on the list?

I'd love to if the price is somewhere I can afford it.

Wouldn't it make sense if we merged with an another groupbuy? I assume it will cut the price down seriously