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Doesn’t CB lose efficacy after 7 months tho?
The Cb (breezula [clascoterone]) Community Thread
- Thread starter Screeech
- Start date
Hey Hair-pun,
I do think they're the safest option, otherwise I wouldn't have ordered from them in the first place. For the transcutol, I use a high purity Diethylene glycol monoethyl ether (>99.7%), which is the same thing as Transcutol. It needs to have a very high purity, otherwise it's not safe for topical use. I ordered it from grntecinc on ebay.
Yeah I get it, I'm fully aware that it could partially be psychosomatic, particularly the feeling in my muscles. However the ball ache is not imagined, I promise you haha. What's your dosage protocol currently?
According to the data, yes, but the explanations presented so far are not very sound (i.e. AR upregulation, HPA axis shutdown, etc.). Honestly, it could be a mistake in the presentation of the data, but that's extremely unlikely. The only way to see would be to compare anecdotal experiences of longterm users with the cassiopea data.
Ah yes, I’m sure there could be side effects- certainly not doubting you when you say this. We all react differently to these drugs. I hope they subside when you find the right dosage. Thanks for the tip off about transcutal. Think I may start with the alcohol/pg/ transcutal vehicle at some point.
Currently I’m using 60mg CB and 20mg RU mixed into 1.75ml alfratradiol (pantostin) once a day after showering. I also use stemox as a vehicle. Both vehicles seem similar to me. I’m pleased I made the jump on to CB tbh. I thought it was game over when dutasteride didn’t fix it but in combo with cb my hair fall has reduced significantly. Unsure how long this will last but will enjoy it while it does!
I would recommend that you stick with it and tinker with your dosage until you find a dosage that works for you. I have done this a few times and I’m happy with mine for now. Give me a shout if you need any more info, I’m no expert but keen to help if I can. Hope it goes well!
The data doesn't indicate it loses it's effectiveness after 7 months, it's still above baseline and well above vehicle after 12 months. The only thing that we can infer from the data is that it wasn't able to maintain growth or potentially fully stabilize loss within 12 months. There is absolutely 0 evidence for AR upregulation, just uneducated guesses because the gains disappeared. This drug also wasn't developed as a growth product, so the only thing we should care about is being above vehicle and baseline longer then 1 year, which, of course we don't know because the study ended.
If it lost effectiveness or sped up hair loss (AR upregulation), then the 12 month results would be equal to or less then vehicle. Instead, it was 9% (or whatever) above vehicle while still being above baseline.
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Fair enough. Only time will tell. Good luck, friend.
Sorry if I came off as aggressive, I just think this thread has devolved into people discussing issues that don't even exist with this drug.
Or if they release the TAHW vs baseline results for the 12 month period.
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No worries. We are all on the edge. It's totally understandable.
Does anybody have a possible explanation as to why some people have experienced anti-androgenic sides on CB (assuming it's legit)? Could it be the vehicle causing too much penetration? Maybe the Transcutol? I also didn't emulsify with Polysorbate 80 and ascorbyl palmitate, so maybe adding those steps to make a more lipophilic solution are vital to achieve a more localized drug delivery effect? Any thoughts would be greatly appreciated.
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I think everything that works has SOME chance with sides. I think if it has a binding affinity strong enough to compete with TEST, it must be able to affect you in some way, systematically, that could cause sides. I'm no expert tho-- pure speculation
This would completely disagree with their study for both the acne version and CB, though. The metabolite is supposed to be almost harmless when systematic.
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I agree and know that's what they said. Just makes me a bit dubious. But then again, what the hell would I know. I'm far from a scientist lol
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Polysorbate 80 on its own might have results in terms of hair loss improvement, which is good, one would think but it might ruin the ability to adjudge what is causing any perceived improvement.
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Isn't it true tho that the results drastically went downhill after about 6-7 months of usage?
They reported hair gains at 6-7 months but almost back to baseline by the 1 year mark. Still ahead of vehicle by 14% or something, though. So it was still effective in some capacity, just wasn't able to hold growth at 1yr.
Chaps,
I’m really struggling to find a lab to test my CB. Most just say they won’t do it, some recommend contacting Cassiopea- another quoted £900!
Can anyone recommend a lab, ideally in the U.K., that I could send a sample to?
Thanks!
I’m really struggling to find a lab to test my CB. Most just say they won’t do it, some recommend contacting Cassiopea- another quoted £900!
Can anyone recommend a lab, ideally in the U.K., that I could send a sample to?
Thanks!
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For much less than that price you could easily ship 5mg to any other civilised country with affordable services.
Ah cool- thanks- can you recommend a reputable company?