The Drug Hydralizine Has Been Shown To Be Superior To Minoxidil In Promoting Rapid Hair Growth

[nameless]

Right, that "minoxidil enhances hair growth because it's a vasodilator" is a myth. Minoxidil stimulates hair growth even in organ culture.

This is excellent and irrefutable evidence.

 

[Bad_Wolve]

cmon guys, what do you want with this stupid hydralizine. maybe it gives you a little bit better results than minoxidil, but this sh*t will take years until its on market. in two years we hopefully will have follica, brotzu and replicel.

 

[kj6723]

cmon guys, what do you want with this stupid hydralizine. maybe it gives you a little bit better results than minoxidil, but this sh*t will take years until its on market. in two years we hopefully will have follica, brotzu and replicel.

Nah dude brotzu is hitting the market in 2016

 

[jamesbooker1975]

A drug could work and affect body in many difference ways.most of the hypertensive drugs don't cause hair growth ( no diuretics, except for spironolactone, no ARAs no Iecas, etc )
About the company , even their site sucks , doubt they will ever hit the market with something.

 

[Teflon Don]

As already mentioned in one of my earlier posts, Carprazidil was also claimed to cause hypertrichosis.

Bianchetti MG, Weidmann P, Boehringer K, et al. Comparative evaluation of the new vasodilator carprazidil and minoxidil in the treatment of moderate to severe hypertension. Eur J Clin Pharmacol. 1982;23(6):483-9.

 

[abcdefg]

I don't know, and personally I benefit from minoxidil in spite of a blood pressure being 110/70.

There is evidence that hair loss is part of metabolic syndrome (high blood pressure, abdominal obesity, low HDL cholesterol, insulin resistance, etc) but it's not conclusive.

What role do hormones play in all this? High DHT/T and estrogen ratios compared to men with much different ones. Do hormones play a large role in someones natural blood pressure levels or obesity or insulin resistance?

 

[cocona]

https://www.newswire.com/news/rober...he-pharma-announces-new-topical-hair-19892599


http://www.rophepharma.com/rphe-7193.php

Not to ruin anyone's day but...

Snipping the entire COX chain would stop synthesis of PGE2 as well. Cox inhibitors have been tried before and actually resulted in more hair loss unless this is somehow different...

Excerpt from the prostaglandin protocol:
"So we have to take care of that nasty PGD2 production. In the past people tried COX1/COX2 inhibitors because that basically removes it right? Well, it didn’t work out. People actually lost more hair because when you snip the chain that high you also remove the beneficial PGE2 prostaglandin chain. COX inhibitors should thus be avoided."

 

[dermrafok]

Not to ruin anyone's day but...

Snipping the entire COX chain would stop synthesis of PGE2 as well. Cox inhibitors have been tried before and actually resulted in more hair loss unless this is somehow different...

Excerpt from the prostaglandin protocol:
"So we have to take care of that nasty PGD2 production. In the past people tried COX1/COX2 inhibitors because that basically removes it right? Well, it didn’t work out. People actually lost more hair because when you snip the chain that high you also remove the beneficial PGE2 prostaglandin chain. COX inhibitors should thus be avoided."

https://www.newswire.com/news/rober...he-pharma-announces-new-topical-hair-19892599


http://www.rophepharma.com/rphe-7193.php

Antoher treatment in the pipeline. That's great.

 

[jamesbooker1975]

The next big thing we will see it is the CTHR2 receptor antagonist, we will see the phase 2 results in a year ( for setipiprant ) and in 2 years Fevipiprant will be available. There is nothing closer in the product pipeline of any real big laboratory, don't count with the forever in phase 2 Cb-03-01 since it is an small company , without nothing on the market and in the last decade the only bid advance is that this people finally put a name for the drug, breezula. Even the acne version will not hit the market faster than the Fevipiprant.

All other stuff, tissue engenier and other things, is still science fictions.

 

[cocona]

The next big thing we will see it is the CTHR2 receptor antagonist, we will see the phase 2 results in a year ( for setipiprant ) and in 2 years Fevipiprant will be available. There is nothing closer in the product pipeline of any real big laboratory, don't count with the forever in phase 2 Cb-03-01 since it is an small company , without nothing on the market and in the last decade the only bid advance is that this people finally put a name for the drug, breezula. Even the acne version will not hit the market faster than the Fevipiprant.

All other stuff, tissue engenier and other things, is still science fictions.

Are you familiar with the differences between Fevipiprant and Setipiprant?

 

[jamesbooker1975]

Are you familiar with the differences between Fevipiprant and Setipiprant?

Yes, fevi is far more potent . Probaly we will need only 150mg daily compare to 2 gr of seti . I am missing something ?

 

[cocona]

Yes, fevi is far more potent . Probaly we will need only 150mg daily compare to 2 gr of seti . I am missing something ?

No idea, I'm no familiar with fevi really. Thanks !

 

[charlie76761]

on the basis that's it's a vasodilator, similar to minoxidil, i'm keen to trial this.

if i can get hold of the tablet form, i can see the active ingredient dissolves in a solvent (Alcohol or DMI/DMSO), but i just need to find an online drug store that ships without prescription - my go-to sites dont stock or are out, does any one know one?

Thanks

 

[MomoGee]

I don't know.
They do have a professional-looking website
http://www.rophepharma.com/index.php
Though they're small since they don't even have a wikipedia page lol.

They're developing three products:
http://www.rophepharma.com/products.php

I stand by my assessment above, best-case scenario is a superior minoxidil a few years down the line. They need to go through a lot of trials first, and they need to get funding.

They'll have to go to less trials though since it's an FDA approved drug that's being repurposed. Also a superior minoxidil is a good thing since there's so many non responders to minoxidil that might respond to hydralazine.

 

[Dolph]

They'll have to go to less trials

Well, they can skip phase I, but that is it. The other three trial (II, IIA, III) will be years.

 

[rupture]

https://www.healthwarehouse.com/hydralazine-25mg-tablets.html

Here are 25mg tabbies for real cheap. I'll do more research to find optimal dosage.

Here is some research I was viewing:

https://www.ncbi.nlm.nih.gov/pubmed/24797896


I would like as many people to read the above and tell me what you think.
@Afro_Vacancy thoughts?



\\*** UPDATE ***//
Looks like the optimal dosage for hypertension lies between 10-25 mg.
Loniten(Oral minoxidil) ranges from 5-25 in a therapeutic dose. So, they are very similar in dosage.

Minoxidil(Rogaine) Reads via google:
Because of the concentration of minoxidil in Regaine for Men Extra Strength Solution, accidental ingestion has the potential of producing systemic effects related to the pharmacological action of the drug (2 ml of Regaine for Men Extra Strength contains 100 mg minoxidil; the maximum recommended adult dose for oral ...Sep 15, 2015"

Therefore, a 1mL administration of minoxidil contains 50mg of minoxidil active.
In terms of hydralazine, it should be similar for 5%. Thus, 2x 25mg tabs in 1mL of vehicle would be a 5% solution, respectively.

I will start lower, at probably half that, meaning 1x 25mg tab per mL.


As far as research goes, I can't find anything about hydralazine affecting androgen inhibition like minoxidil. If anyone else would like to chime in, that would be great.

I actually contacted them and asked them about response rate . I do not respond to minoxidil even 10 mg of loniten does nothing. He said a lot of minoxidil non responders were responding to this. Do you trust your source ? ADC has it listed but says they are out

 

[rupture]

https://www.healthwarehouse.com/hydralazine-25mg-tablets.html

Here are 25mg tabbies for real cheap. I'll do more research to find optimal dosage.

Here is some research I was viewing:

https://www.ncbi.nlm.nih.gov/pubmed/24797896


I would like as many people to read the above and tell me what you think.
@Afro_Vacancy thoughts?



\\*** UPDATE ***//
Looks like the optimal dosage for hypertension lies between 10-25 mg.
Loniten(Oral minoxidil) ranges from 5-25 in a therapeutic dose. So, they are very similar in dosage.

Minoxidil(Rogaine) Reads via google:
Because of the concentration of minoxidil in Regaine for Men Extra Strength Solution, accidental ingestion has the potential of producing systemic effects related to the pharmacological action of the drug (2 ml of Regaine for Men Extra Strength contains 100 mg minoxidil; the maximum recommended adult dose for oral ...Sep 15, 2015"

Therefore, a 1mL administration of minoxidil contains 50mg of minoxidil active.
In terms of hydralazine, it should be similar for 5%. Thus, 2x 25mg tabs in 1mL of vehicle would be a 5% solution, respectively.

I will start lower, at probably half that, meaning 1x 25mg tab per mL.


As far as research goes, I can't find anything about hydralazine affecting androgen inhibition like minoxidil. If anyone else would like to chime in, that would be great.

Thats a Canada pharm still need script

 

[hellouser]

https://www.healthwarehouse.com/hydralazine-25mg-tablets.html

Here are 25mg tabbies for real cheap. I'll do more research to find optimal dosage.

Here is some research I was viewing:

https://www.ncbi.nlm.nih.gov/pubmed/24797896


I would like as many people to read the above and tell me what you think.
@Afro_Vacancy thoughts?



\\*** UPDATE ***//
Looks like the optimal dosage for hypertension lies between 10-25 mg.
Loniten(Oral minoxidil) ranges from 5-25 in a therapeutic dose. So, they are very similar in dosage.

Minoxidil(Rogaine) Reads via google:
Because of the concentration of minoxidil in Regaine for Men Extra Strength Solution, accidental ingestion has the potential of producing systemic effects related to the pharmacological action of the drug (2 ml of Regaine for Men Extra Strength contains 100 mg minoxidil; the maximum recommended adult dose for oral ...Sep 15, 2015"

Therefore, a 1mL administration of minoxidil contains 50mg of minoxidil active.
In terms of hydralazine, it should be similar for 5%. Thus, 2x 25mg tabs in 1mL of vehicle would be a 5% solution, respectively.

I will start lower, at probably half that, meaning 1x 25mg tab per mL.


As far as research goes, I can't find anything about hydralazine affecting androgen inhibition like minoxidil. If anyone else would like to chime in, that would be great.

Do you have a log thread anywhere?

 

[rupture]

There's this site people use a lot but I forgot the name. We'll have to do some searching

If your thinking of In House , they don't carry it

 

[Afro_Vacancy]

https://www.healthwarehouse.com/hydralazine-25mg-tablets.html

Here are 25mg tabbies for real cheap. I'll do more research to find optimal dosage.

Here is some research I was viewing:

https://www.ncbi.nlm.nih.gov/pubmed/24797896


I would like as many people to read the above and tell me what you think.
@Afro_Vacancy thoughts?



\\*** UPDATE ***//
Looks like the optimal dosage for hypertension lies between 10-25 mg.
Loniten(Oral minoxidil) ranges from 5-25 in a therapeutic dose. So, they are very similar in dosage.

Minoxidil(Rogaine) Reads via google:
Because of the concentration of minoxidil in Regaine for Men Extra Strength Solution, accidental ingestion has the potential of producing systemic effects related to the pharmacological action of the drug (2 ml of Regaine for Men Extra Strength contains 100 mg minoxidil; the maximum recommended adult dose for oral ...Sep 15, 2015"

Therefore, a 1mL administration of minoxidil contains 50mg of minoxidil active.
In terms of hydralazine, it should be similar for 5%. Thus, 2x 25mg tabs in 1mL of vehicle would be a 5% solution, respectively.

I will start lower, at probably half that, meaning 1x 25mg tab per mL.


As far as research goes, I can't find anything about hydralazine affecting androgen inhibition like minoxidil. If anyone else would like to chime in, that would be great.

Will you dissolve these tablets in a topical, or swallow them?