Review about side-effects in all clinical trials, including Peyronies' Disease.
A literature review of adverse side effects associated with 5αRIs shows that persistent sexual side effects were only documented in low-quality studies with strong bias selection as participants were part of an Internet blog. The only high-quality study documenting persistent sexual side effects showed that these were more frequent in the placebo than in the treatment group, implying that the effects were not necessarily related to the treatment. A significant placebo/nocebo effect has been documented among patients informed about possible side effects of finasteride and this may explain the high prevalence of reported sexual dysfunction including persistent dysfunction in subjects participating in Internet groups and blogs. Psychiatric side effects were only documented in moderate- or low-quality studies including studies performed on patients with sexual side effects, which could influence patient's mood. Most of these studies recruited patients through the same Internet patient website.
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