1 year + 2 month Update
Date: 08/10/2012
Topics: Lessons from Minoxidil Discontinuation,
Update on Scalp Flaking,
Update on Spironolactone,
Upcoming Vertex Trials,
AHK-Cu Trial,
Haircut Pictures,
Updated Regimen
Hi guys, I’m back. Thanks for all the positive feedback and comments – Captain & RW & yassin I really appreciate your continuing to follow my progress, and IrishFella it’s good to see you back around here. More good news to report this month; progress continues and I have a few new things to say.
Lessons from Minoxidil Discontinuation
All-in-all, I couldn’t be happier with the way things are going. It looks like I’m back to full strength after the minoxidil slip-up this spring, from which I learned that for me personally I can expect to lose the minoxidil hair about 2 months after discontinuing use, and that, after resuming, early results appear after about a month-and-a-half with full results coming after about three months, consistent with my initial round of treatment one year ago. It also underscores the importance of
discipline in executing your regimen to generate and sustain positive results.
Update on Scalp Flaking
More good news is that the scalp flaking has finally stopped. I still don’t know exactly what was causing it, but I’m no longer shedding hair, no longer itching, and no longer have those flaky bits cropping off of my scalp. I guess at this point I’ll just sum it up to some transient dryness and sensitivity and be happy that it resolved.
Update on Spironolactone
So it seems I’ve stabilized once again with regular use of finasteride (1.25mg/day), minoxidil (5% 2mL 2x/day), and ketoconazole (2% shampoo 2-3x/week), while supplementing with omega-3s (1.5g/day), biotin (10mg/day), and MSM (3g/day). It is worth mentioning that I never really resumed regular use of spironolactone. I had last used spironolactone daily during April, stopped for May due to excessive flaking (not necessarily related to spironolactone use), then proposed to resume in my June post but have never really gotten the hang of it again…I threw it on a couple times during June and July just to finish the tub I had already opened, but having maintained and improved my results despite not regularly using spironolactone over the past three months casts doubt over the necessity of that treatment, especially given that it is the most expensive part of my regimen.
My conclusion thus far is that the big 3 works for me, and including those few nutritional supplements is a simple and inexpensive contribution which may benefit general health as well. I would have no problem additionally continuing spironolactone use, and for those with no budgetary limitations I would not hesitate to recommend including it in your regimen in addition to the big 3 (unless a more potent topical anti-androgen like RU or CB/17ap is being used). But for me right now I’m going to put the spironolactone on hold to make room to test alternative secondary topicals, which I’ll discuss in the next section.
Upcoming Vertex Trials
As I mentioned, the main reason I’m discontinuing the spironolactone use is so that I can incorporate another topical into the regimen (going for 3 separate topicals at once would be a little tricky). So far I’ve had really good regrowth all over, especially at the hairline – it’s as low and dense as it’s ever been in my life – but less so at the vertex. Don’t get me wrong, I’m completely happy with the results so far and if I didn’t grow another new hair I’d be totally satisfied just having gone back to a normal balding pattern. At 27 years old now, the appearance of a thinning vertex is not as unusual as NW6 was at 24 years old.
But given that I’ve responded well to everything so far and have begun to appreciate the experimentation and knowledge-generation aspects of treatment (and also that I have 8 grams of pure AHK-Cu sitting in my fridge) I wanted to continue trying a few alternative treatments to both gauge their effectiveness and attempt to generate some new growth on the vertex. I don’t know that more growth at the temples is even possible, so for evaluating additional treatment options I think the vertex is an ideal proving ground. My former strategy was to get on the big 3 then incrementally add in additional products based on their ease of availability and reported effectiveness, but that process becomes costly and prohibits the simultaneous use of multiple topicals. Therefore I’m going to continue holding off on the formerly used Retin-A and Spironolactone while testing out some additional treatments one-by-one. I know that I tolerate those two things well but they don’t seem to have added much beyond the big 3 for me at this point; so rather than continue piling things on I’m going to keep them in the arsenal for inclusion in case my results from the big 3 begin to falter in the future.
At this point, I plan to use the 8 grams of AHK-Cu on hand for a five-month trial run, from August through mid-January, to be discussed in the next section. Hopefully any results will begin to show during that period if there are any to be had from this treatment. I then plan to undertake anti-fibrotic Aminexil treatment for the necessary six weeks from next February through mid-March, then kick up the minoxidil to 15% for a month during next April. After that we’ll see – most likely a course of miconazole nitrate, about which I’m most excited, but it all depends if any of the new stuff (bimatoprost, RU, CB, ASC, OC) is commercially available at that point (probably not).
AHK-Cu Trial
So since I’m back to full strength and have stabilized on just the big 3 over the past few months with still room to improve on the vertex, and I have some AHK-Cu and a bottle of Tricomin on hand, I’ve begun the process of testing out the effectiveness of these treatments as supplements to the big 3 to either generate new growth or thicken the sparse existing growth on the crown. In this way I’ll also require only half the amount relative to all-over application, allowing me to extend the duration of the study to be twice as long.
I propose to do the following:
Month 1 – August – Add 1.3g to 60mL Tricomin (2.5%), use 1mL twice per day
Month 2 – September – Add 1.3g to 60mL Tricomin (2.5%), use 1mL twice per day
Month 3 – October – Add 2.6g to 60mL Tricomin (5%), use 1mL once per day
Month 4 – November – Continue using previous month’s 5% preparation
Month 5 – December – Add 1.3g to 30mL alternative vehicle (5%), use 1mL once per day
As always, not perfectly scientific, but if any part of these combinations shows promise it would provide justification for continued exploration and refinement to pin down the optimal method of application. It is also worth mentioning that the percentage concentrations are going to be approximate for the first four months because the pre-existing concentration of AHK-Cu in Tricomin is not known with certainty but rumored to be between .1% and 1%, and please don’t start that argument here. For reference, here is the thread on AHK/vehicle proportioning I started back in April:
http://tiny.cc/qsrviw.
I’ll be keeping track with regular pictures at the first of each month with particular focus on macro-mode documentation of the vertex. I’m also taking a 50mg zinc picolinate supplement every morning in an effort to maintain a consistent zinc:copper ratio, as this ratio has been found to be important for a variety of functions and is perhaps more relevant biologically than the total amount of either substance alone.
I am a bit concerned, though, about the Tricomin interfering with the minoxidil, in particular Tricomin’s amodimethicone ingredient, which is a silicone that can build up on the scalp and impair permeability for other topicals. It is apparently stripped away by certain surfactants, namely cocomidopropyl betaine…the Aveda Pure Abundance shampoo I use contains a similar surfactant (babassuamidopropyl betaine) so hopefully that is enough to prevent interference. An alternative vehicle of water, ethanol, and PG could also be used to deliver the AHK, but for now I’m going to assume the Procyte/PhotoMedex people are accurate when they say that Tricomin can safely be used with minoxidil. If I get the telltale shed from the vertex after two months I’ll certainly reconsider and switch to an alternative vehicle.
When the bulk AHK was first going around I know some people dumped it straight into their minoxidil formulae and still reported some potential interference, so with all these concerns in mind I’m going to space the AHK applications far away from applications of minoxidil (which reportedly reaches full absorption after four hours). I’ll apply minoxidil first thing in the morning (7 AM), the AHK about five hours thereafter (12 noon), shower after an evening workout to remove the AHK and immediately apply minoxidil again to a fresh scalp (7 PM), then make the last application of AHK five hours later (12 AM) before I go to bed around 1 or 2 AM. In this way I hope to minimize the risk of AHK/Tricomin – minoxidil interference; the only overlap being the morning application of minoxidil over top of the previous night’s application of AHK. Remember that I’ll be applying minoxidil all over but AHK only to the vertex. Fortunately the Tricomin/AHK 2.5% mixture I’m currently using, although dark blue, doesn’t seem to discolor the scalp at all in the way that Folligen did, therefore the mid-day application shouldn’t pose any practical problems for me.
Let me know what you think about this proposal if you have any feedback. I just initiated day 1 of 2x/day 2.5% AHK yesterday, August 10. Looking forward to keeping you updated and adding to the sparse anecdotal evidence on how Tricomin and supplemental AHK-Cu fits into a keto/finasteride/minoxidil regimen.
The last thing to note is that since I have one 180mL bottle of Tricomin while my trial calls for 210mL of vehicle, I’m actually in need of an additional 30mL. I’d rather try something else besides the Tricomin, probably a simple water/ethanol/propylene glycol solution, since this is what many people were using for their AHK last year. Does anyone have recommendations for a particular ratio? To promote maximal absorption I want to increase the non-volatile component (PG) as much as possible while maintaining solubility…I’m thinking 20:40:40 water:everclear
G. The risk is that the AHK won’t fully dissolve, in which case I can add water and ethanol in fixed proportions and increase the volume I apply each time correspondingly to maintain the same quantity of active ingredient. Anyone with experience please chime in. Thanks!
Haircut Pictures
I was fortunate enough this month to snap pictures immediately prior to
and immediately following my monthly haircut, since I always seem to grab pics under one condition or the other. Hopefully this will give a more comprehensive picture of my progress. The pictures are from one week ago today, August 4, 2012.
Before haircut - 3 with flash off:
Before haircut - 5 with flash on:
After haircut - 5 with flash off:
After haircut - 5 with flash on:
Closeup of Crown - flash off / flash on:
Updated Regimen
Inflammation
Keto 2% Shampoo, 2-3x/week
*TRIAL: Tricomin+AHK-Cu, 2.5% 1mL 2x/day
DHT
Finasteride 1.25mg/day
*ON HOLD: Spironolactone 5% 1mL 2x/day
Growth
Minoxidil 5% 2mL 2x/day
*ON HOLD: Retin-A .05% ~250mg 1x/day
Supplements
Multi 1x/day
Omega-3s 1.5g/day 2:1 EPA-DHA
Biotin 10mg/day
MSM 3g/day
Zinc Picolinate 50mg/day (for AHK-Cu Trial)
Thanks for reading this incredibly long post! Leave a message and check back the first week of September to see how things are progressing with the AHK trials.