Yeah, I don't buy that for a second, for a few reasons:
1) There's no evidence that the APM is required for terminal hair growth. In fact, sea otters don't have APMs and their hair does just fine.
2) The connection to the APM is severed during hair transplants. After transplanting the new hair follicle, the follicle establishes a new APM connection. Also, Tsuji's hair germs (using just the dermal papilla cells and epithelial stem cells of the follicle) also organize perfectly fine into a fully functional HF, and these establish APM connections as well.
3) Actually, A.G.A is highly reversible in many cases. It's just that current treatments don't effectively reverse it. One exception: Strong anti-androgens combined with 17beta-estradiol. Even though not everyone who uses these gets amazing results, reversal of multiple Norwoods happens
reasonably often. With conventional treatments, this happens very rarely. But the results of transgenders blow away a lot of these ideas.
I think to best explain this phenomenon, we should look at analogous characteristics of similar traits to A.G.A. What are similar traits to A.G.A? Any other developmental hair growth trait, basically. Unibrows, eyebrow thickness, beard thickness, body hair, etc. We can see this from the genetics of these traits. I discussed this before:
What can conventional treatments do for facial hair growth, or forehead hair growth? Well, here are some "good responders" to minoxidil.
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That's a lot of peach fuzz, but will those girls ever grow a beard like this on just minoxidil?
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Probably not. Minoxidil isn't enough to compensate for lack of the powerful hair follicle development program the genetic data implicate (probably launched in response to DHT). Same might apply to A.G.A - minoxidil very rarely regrows thick terminal hair in slick bald areas (one of the very rare exceptions is of course Somebody). Meanwhile, one thing that does seem to activate the fundamental developmental pathways in frontal scalp HFs is 17beta-estradiol, but that's a post for another time.
Come ooooooooooooooonnnnnnnnnnnnnnnnnnnn.
With the proper tools, a lot more probably would.