7 years of high dose dutasteride (2mg every day)
Respect. For real.
Just for cost alone, most guys won't do more than 0.5mg dutasteride ED. With Avodart, that's around US $30 per month for 0.5 vs. $120 for 2mg, it adds up quick over a long time. But the 2006 Olsen study plus others show that dutasteride is dose dependent, and even with decreasing marginal gains from higher doses, I like the idea of higher doses. (I can't post links because I'm still too new here, sorry, but the 2006 Olsen study you probably know anyway:
The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride).
Ever considered cutting the dutasteride dosage slightly and adding in finasteride to reduce costs a bit? You know all the questions about type I vs. type II, but by using both the dutasteride plus the finasteride, you still get type I suppression from the dutasteride, then you have both dutasteride and finasteride working on type II. I've seen some guys on forums try it, something like 0.5 dutasteride + 1.25 finasteride ED. There's a case study which a doctor in Australia published on a patient where he found that adding dutasteride, although at very low dose, helped where finasteride wasn't working (Boyapati, 2013,
Combination therapy with finasteride and low-dose dutasteride in the treatment of androgenetic alopecia).
I think I have reflex hyperandrogenicity (my androgen receptors are now very very very sensible to DHT/Testosterone, even at low levels)
I've worried about this a lot for myself. What made you think you have reflex hyperandrogenicity? What effects have you noticed in your body?
And I insist, with Cypro + Bica + (1mg) Duta my libido is fine
Cypro + Bica + 1mg dutasteride = fine.
Cypro + Bica + 2mg dutasteride = libido problems.
Damn, the real world is so much more complicated than what we expect in theory. Donate your body to science lol ;-)
But seriously, how are other hormone-type sides for you with the cypro and bica? Gyno, skin, ejaculation quality/amount, fat distribution, muscles...?
I think bicalutamide could be harmful to hair, because it increase testosterone and so DHT and bicalutamide à 25-50mg is not strong enough to block DHT effects on follicles. I say that from my experience, but maybe it's because I have reflex-hyperandrog...
Bicalutamide being harmful to hair? That's big. Was the timing of when you started different treatments staggered enough that you can you isolate the effect of bica actually being harmful to your hair in your own experience?
Me, I'm researching a lot for a high-strength regimen I'm comfortable with. I'm already with the usual dutasteride, finasteride, minoxidil, dermapen, but I'm more willing than most here to add in a combination of a bunch of anti-androgens - spironolactone, cypro, bica, flutamide - maybe with some estrogen form, so I've been doing a lot of research now on them. I was also thinking about topical darolutamide until JLF just told me on another thread that it would be around $500-800/month.
