I have been using oral duta 0.5mg day and topically once weekly for 7 months from a pharmacy in the US, hair got flatter less volume and thickness, no change at front no thickening of weak thin hairs, then I took 2.5mg to 2mg of oral duta instead and used topically x3 times weekly 7 months later hair is EVEN thinner and flatter at the crown area, so depressing, my itch went away and shedding went down a shitttt load but still balding. I think it could be scalp T or I got some other type of balding other than just male pattern baldness. oral dutasteride just at 0.5mg day increases scalp testosterone by 100% and 2.5mg increases it by 150% or 200%, if you also use dutasteride topically you will block even more scalp DHT so then you will end up with 200% increased scalp T or more. T can be bad for hair too, there needs to be a balance between T and DHT, nuking all serum dht and scalp DHT hasnt done sh*t for me due to the huge spike in scalp T. im quitting topical now and only using the recommended 0.5mg oral duta everyday, otherwise my scalp T goes insanely high. and yes T can also be bad for hair trust me. the only side effect I have from dutasteride is my sperm oozes out dribbles out from my penis it no longer shoot out with force.
I recommend that u do not add topical duta if you are already using it orally, studies say oral duta outperformed topical duta and mesotherapy, at least what moreplatesmoredates the youtuber said. you will end up spiking scalp T insanely high if you do which is bad.
Do you know if there were any studys showing the scalp DHT different between oral and topical dutasteride? I can‘t imagine the topical inhibits up to 90% while oral just 60-70%
well if u look at the finasteride studies of topical finasteride, topical finasteride blocked more scalp DHT than oral...something like 50% was blocked topically and orally 40%, some studies probably show higher numbers for topical finasteride. so in the end topical DOES block more scalp DHT than oral which makes sense because you apply it directly to the scalp while oral it spreads throughout your system and finally reaches the scalp. but finasteride penetrates better into the scalp due to the small mouculer mass, while dutasteride has a much harder time to penetrate into the skin without needling because its over 500 daltons, but I have read people say that they have experienced side effects from topical dutasteride and some of them werent even dermarolling or stamping so it can infact go deep enough into the skin and even reach the blood without needling but it depends on the formula. im actually quitting oral dutasteride and gonna apply it topically only instead because oral hasnt really helped. also I cant shoot out my sperm anymore due to oral dutasteride.
well my broscience is saying less scalp DHT inhibition -> less results. But I always believed oral finasteride is more effective than topical (until it's liposomal maybe). It's irritating and hard to find info about the real value of scalp DHT. Every topical should be more effective in theory then but it just don't seem so.
which topical dutasteride are you using? and couldn't it be possible your T spikes are too high with that heavy dutasteride regime if you're still thinning?
for the first 7 months I was using murray avenues apothecary topical dutasteride once weekly and used it orally 0.5mg day hair got thinner, but its weird how it could spike T so much that I would go bald from it, my T isnt naturally high to begin with its actually on the lower side. DHT is worse for hair than T, my scalp itch on front and hairline even vanished while on a heavy dutasteride regiment and my shedding in shower eventually went down to 3-4 hairs from 35-50. so doubt scalp T is nuking my hair. I probably have another cause for my thinning hair than simply DHT/T, it could be many reasons. for one my hair has been growing super slow for years despite having THICK hair strands it just wont grow long in certain places anymore.
But did your hai thicken up?
Im not too bad. Bit thinner but without dutasteride i would have very thin hair today. My hairline looks the same and front 1,2 years later. One guy messaged me and said he thinned out for 2 years on dutasteride but then hair got thick...i cant even tolerate fina so cant even use it but dutasteride has shown in trials to grow more hair than fina so dont make any sense what you say.
Thing is. For me Finasteride was great and dutasteride thinned me out like crazy. I stopped shedding hundreds of hairs but it seems i am shedding 200/300+ hairs again a day