Topical Finasteride Goes Systemic Comfirmed

[scientist_0005]

Dude, you are beyond incredibly dumb then. I did not say that the amount absorbed wouldn't be less if applied topically. I know that, it's obvious. However, some amount will go systemic, and for many people, even just a small amount is enough to cause bad side effects, just like the OP said and quite a few other people in this thread alone. There's also many many people on this forum alone who reported side effects after using Topical Finasteride.

0.005% of finasteride is 0.05mg.around 10-15% of if gets absorbed. you are looking at levels of finasteride in your blood that could not even be traced anymore. sure it can accumulate but there is a limit to that as well. there are more natural fluctations in dht than there are with 0.01mg. in fact look at the vehicles, sometimes it is 10% down from baseline as well. there are not many people who have tried this regimen, thats hust a fact. and that is also not scientifically rigorous either. if people want to do this, they need to measure their dht levels. i do not believe that anybody is this sensitive to finasteride that such laughable traced give them such unbearable sides. it makes no sense if their hormones are not completely out if whack

 

[scientist_0005]

Well, technically speaking oral inhibition is also dose dependent, you just have more leeway with topical because of a localized effect (of which only a part will go into circulation).

I don't disagree with your theory, it's just that many people have tried this over the years and as far as I know, most if not all of them have failed. But I would love to see someone do it successfully. At such low levels of finasteride it becomes a matter of efficacy though.

Finasteride's halflife is not particularly relevant by the way, it's more about the 5ar2 turnover rate. I can hook you up with some articles if you want to explore your theory further and put it to practice.

yeah of course i am saying just that, you can actually micro dose with topical because the response curve is not this incredibly steep when it comes to systemic impact. you have more control over how much systemic dht yiu want to inhibit. half life is still important though when people talk about accumulation ovef days but you are right that 5ar turn over rate is more important. i do believe however there is a sweet spot for most people where the turn over exceeds the inhibition and thus further saturation cannot occur. i dont know where you get this many people from but i read of some people on reddit who use very low amount of topical finasteride and they got their dht measured and it was same as before everytime. so this is muvh more valuable than asking someone if they experience loss of libido because the chance is in fact quite high that someone whk tries a topical micro dosing is extremely aware or scared of those side effects

 

[corkmeister]

yeah of course i am saying just that, you can actually micro dose with topical because the response curve is not this incredibly steep when it comes to systemic impact. you have more control over how much systemic dht yiu want to inhibit. half life is still important though when people talk about accumulation ovef days but you are right that 5ar turn over rate is more important. i do believe however there is a sweet spot for most people where the turn over exceeds the inhibition and thus further saturation cannot occur. i dont know where you get this many people from but i read of some people on reddit who use very low amount of topical finasteride and they got their dht measured and it was same as before everytime. so this is muvh more valuable than asking someone if they experience loss of libido because the chance is in fact quite high that someone whk tries a topical micro dosing is extremely aware or scared of those side effects

Well, you seem pretty sure of your case, I hope it works out.

 

[MrKmass]

so this further proofs my point then, it is a dose dependent inhibition unlike oral intake. in the polichem trials they had 24% reduction in dht after 7 days with the 0.2mg /ml dose. based on mozarellas study, we know that dosage as low as 0.005% which translates to 0.05mg /ml does not result in systemic impact but can give benefits for hair count after many months. so it is quite reasonable to assume that an effective dose exists where the half life outcompetes the accumulation of drug and a consistent inhibition is met. that seems to be the case with the 0.005% but could be even higher. if we use the 0.2mg 0.02% solution, at the end of the 7th day we have 24% reduction. if we apply half of that it should be substantially lower just by the fact that half life of finasteride is 15 hours. lets say to prevent accumulation you in additoon to using an even further reduced dosage(which still inhibits scalp dht around 80% of what oral finasteride does) and take a day off for example once or twice a week which is not enough for scalp dht to rebound but for systemic impact to clear out due tk the short half life

then this is a regimen that could be somewhat effective at at least maintaining hair and have very low systemic impact. you can even use 2-3ml bc with mozarella protocol you only use 1/5th of that dosage.

why would this not work? there is people i have talked to that tried various topical finasteride dosages and found that 0.004% per day, slightly less than mozarellas study had ZERO systemic dht reduction. it is not unreasonable, i think its probably more effective than stuff like low dose CB as well tbh

This has been my protocol for 5 months now: 0.05 mg of finasteride per mL. 3 ml for the scalp.

 

[scientist_0005]

This has been my protocol for 5 months now: 0.05 mg of finasteride per mL. 3 ml for the scalp.

thats a treatment i would have proposed. how is it going for you? did you have sides in oral finasteride? for me, i have only one side on oral finasteride and its very strange but i get pretty bad ED, like, it is a non sustainable for longer periods of time. it works well with cialis but thats some bs regimen and i would also not commit to that

 

[MrKmass]

thats a treatment i would have proposed. how is it going for you? did you have sides in oral finasteride? for me, i have only one side on oral finasteride and its very strange but i get pretty bad ED, like, it is a non sustainable for longer periods of time. it works well with cialis but thats some bs regimen and i would also not commit to that

Yes I have had side effects from oral finasteride, even in micro-doses. Violent pains in the balls. And also slight drop in libidio and watery semen.

I must admit that topically at a higher dosage I had the same side effects but milder. However at my current dose, no side effects in 5 months.

Edit : Yes, topical finasteride becomes systemic but much less, a low dose allows you to have some of the advantages without the disadvantages

 

[Micky_007]

0.005% of finasteride is 0.05mg.around 10-15% of if gets absorbed. you are looking at levels of finasteride in your blood that could not even be traced anymore. sure it can accumulate but there is a limit to that as well. there are more natural fluctations in dht than there are with 0.01mg. in fact look at the vehicles, sometimes it is 10% down from baseline as well. there are not many people who have tried this regimen, thats hust a fact. and that is also not scientifically rigorous either. if people want to do this, they need to measure their dht levels. i do not believe that anybody is this sensitive to finasteride that such laughable traced give them such unbearable sides. it makes no sense if their hormones are not completely out if whack

Unfortunately people suffer side effects from Topical Finasteride or even Topical Dutasteride, or almost any Topical Anti-androgen whether you "believe" it or not

 

[Micky_007]

thats a treatment i would have proposed. how is it going for you? did you have sides in oral finasteride? for me, i have only one side on oral finasteride and its very strange but i get pretty bad ED, like, it is a non sustainable for longer periods of time. it works well with cialis but thats some bs regimen and i would also not commit to that

You just said you had one side effect from Oral Finasteride which is "bad ED" , as if one side effect of this nature isn't massive. Also, you said this "bad ED* was "very strange", but such a side effect is actually extremely common with Oral Finasteride, and not strange at all.

 

[scientist_0005]

You just saidyou had one side effect from Oral Finasteride which is "bad ED" , as if one side effect of this nature isn't massive. Also, you said this "bad ED* was "very strange", but such a side effect is actually extremely common with Oral Finasteride, and not strange at all.

i trust the studies and biology more than a bunch of anecdotes actually

 

[scientist_0005]

we are talking about amounts here that are so small they cannot even be detected in the blood serum lol. 0.15*0.05mg is 0.0075 mg, it is impossible to get statistically significant dht reduction from that.

 

[Micky_007]

Impossible is a strong word, which you are not capable of determining. And also, there are many studies of people who use topicals that go systemic and cause side effects. You just chose to focus on the false/bribed studies that try to make Finasteride look good.

 

[scientist_0005]

Impossible is a strong word, which you are not capable of determining. And also, there are many studies of people who use topicals that go systemic and cause side effects. You just chose to focus on the false/bribed studies that try to make Finasteride good.

no lol. you did not even read this thread did you? of course if you junk 2mg of finasteride topically on your head it gies systemic to a significant amount. but 1/50th of that? dose escalation studies suggest not really

 

[scientist_0005]

ill just say yiur studies are bribded too, its that easy

 

[Micky_007]

ill just say yiur studies are bribded too, its that easy

The reason why this argument of yours doesn't work is simply because these real independent studies don't have the funding of Big Pharma to bribe them. It's common knowledge how corrupt Big Pharma and even the FDA is/can be.

And Yes I've read this thread.

LOL you went and tried to dislike even the status on my profile that says I don't use Finasteride. Clearly you're a Pro-Finasteride person. Your blind argument becomes even more invalid.

 

[scientist_0005]

The reason why this argument of yours doesn't work is simply because these real independent studies don't have the funding of Big Pharma to bribe them. It's common knowledge how corrupt Big Pharma and even the FDA is/can be.

And Yes I've read this thread.

LOL you went and tried to dislike even the status on my profile that says I don't use Finasteride. Clearly you're a Pro-Finasteride person. Your blind argument becomes even more invalid.

lol the air head big pharma conspiracy. there is independent studies but you do not want to make a solid argument. what ever, if thats your ideal stop posting here and let adults find s regimen that works

 

[Micky_007]

lol the air head big pharma conspiracy. there is independent studies but you do not want to make a solid argument. what ever, if thats your ideal stop posting here and let adults find s regimen that works

If you believe Big Pharma isn't corrupt you are more delusional than I thought, LMAOOOO.
Also, those "independent studies" that are pro-Finasteride are just bribed by Big Pharma money secretly.
As you have already encountered in this thread, several adults including myself all told you you're talking BS. But yes I have better things to do than argue with a gullable kid.

 

[scientist_0005]

ok so you think 0.05mg finasteride causes significant dht reduction. got ya, thats ridiculous

 

[Warmer82]

I take maxegen- x definitely started having side effects after a month 0.15% finasteride. Been on it for over a year. Sides reduced around 6 months in. Ive heard topical finasteride increases your scalp testosterone. So going to try ru58841 with it.

 

[supermusic]

but no pharmaceutical company would be interested in marketing topical finasteride today. Therefore I do not understand what dark interest there could be behind these studies.