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If I could like this twice, I would.
Ucla Scientists Identify A New Way To Activate Stem Cells To Make Hair Grow
- Thread starter hellouser
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If I could like this twice, I would.
Some of us going to try using something like sodium lactate and see if that does anything. Using UK is too risky - blocking the energy to the mitochondria basically means you're starving it to death. There is no coming back from death - only (hopefully) miniaturization.
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How do you know? Did you two go on dating?
Just a few laws and maybe a code of ethics for scientists standing in the way. I'll admit, tho, I'd love to see a cowboy gung-ho type, a Dr. Frankenstein-like UCLA researcher skip the lab test animals and make a beeline straight to an "IT'S ALIVE!" eureka moment for hair loss. That'd be rilly cool.
“Life, although it may only be an accumulation of anguish, is dear to me, and I will defend it.” - Mary Shelley's 'Frankenstein'
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H
Senior Member
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You want to keep your nw6?
Its funny because a guy just posted about levels of lactate causing male pattern baldness like a day or two ago. Kudos to that guy he figured this out before this study came out to solidify that.
With how complicated male pattern baldness is though we need to see this work in humans before its worth getting excited about. We dont know how significant this is yet if its a huge player or a minor one. Sometimes certain pathways turn out to be minor contributors, and the results of manipulating it arent as impressive as they sound on paper.
This does sound like it could be close to a root cause of male pattern baldness, but one discovery at a time. Might be decades before this bears fruit.
With how complicated male pattern baldness is though we need to see this work in humans before its worth getting excited about. We dont know how significant this is yet if its a huge player or a minor one. Sometimes certain pathways turn out to be minor contributors, and the results of manipulating it arent as impressive as they sound on paper.
This does sound like it could be close to a root cause of male pattern baldness, but one discovery at a time. Might be decades before this bears fruit.
H
Senior Member
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Go look at the beginning of that thread your referring to please.
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You don't date...but would you let them suck you off? (Lights off)
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H
Senior Member
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Damn thats a good point. Is there an organization of balding men sucking other balding men off? If they have a Congress Ill get the coverage.
H
Senior Member
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Theyre all balding? Guess I'd prefer a mutual agreement type arrangement but whatevs one of you will have meet me at the fence during yard time so I can throw my journal with interviews over and post them.
Agreed 110%
My hype for this news, if you were to put a number on it, lies at exactly zero; studies like this have been published for decades and precisely f*** and all has come from them toward an actual treatment in 90% of cases. IIRC, it was a student or something that made this discovery? Just some neat find that looks good on a resume and won't actually be pursued further
and even if it is, and it could be used to develop something worthwhile, it's too far off for me to give a sh*t.
H
Senior Member
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I do think it'd be interesting to see what it does for humans but it's definitely not going create new hair unfortunately.
UCLA scientists don't discover how to activate stem cells in vivo every day, but when they do they get the research published in Nature Cell Biology, a prestigious peer-reviewed scientific journal. Yup this could be huge.
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How is your sodium lactate trial going? I've been pondering about trying UK5099 with minoxidil for a few weeks but your post gives me cause for concern. Potential side effects aside, I think it's application is a one time process which is not reversible? There is some info on it's solubility, not sure if it will mix with minoxidil (can't link so will paste below):
For long term storage, we suggest that UK 5099 be stored as supplied at -20°C. It should be stable for at least two years. UK 5099 is supplied as a crystalline solid. A stock solution may be made by dissolving the UK 5099 in the solvent of choice. UK 5099 is soluble in organic solvents such as DMSO and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of UK 5099 in these solvents is approximately 5 and 15 mg/ml, respectively.
UK 5099 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, UK 5099 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. UK 5099 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMFBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Pyruvate transport into mitochondria is facilitated by mitochondrial pyruvate carrier (MPC) 1 and 2, two small transmembrane proteins that are part of a larger 150 kDa protein transport complex in the inner mitochondrial membrane. UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with an IC50 value of 50 nM.