What if they show you pictures of ten slick bald people with a full head of hair after phase I? Wouldn't that be enough for you? It would for me. I can't afford the 750k for hair, but if it was 100k I'd be begging them to take my money for a chance to have hair two years sooner than everyone else.
Update From The God Himself - Dr. Takashi Tsuji
- Thread starter kingjohn
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Yes but that's not what they'll be doing for a phase 1 safety test & proof of human concept test, otherwise that's exactly what I just said. The phase 1 test is going to be patches of hair on bald scalp, similar to the Stemson or Tsuji mice pictures. Would pictures of 10 follicles in one spot after 90 days encourage you to drop 750k if you knew nothing else about the science?
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Yes. That line about God offended me. It's Goddess....
Tsuji told you this, or someone else at RIKEN? I would have thought they'd do at least one full scalp procedure in phase I to show off. They should all be full scalp procedures. Preclinical would be just a one cm spot, then the clinical trials should be exactly what they are going to do in the clinic, otherwise it's not a true test.
Before doing a phase I they do a smaller safety test in humans. This will be where they test 1cm².
"Phase 0 involves exploratory, first-in-human (FIH) trials that are run according to FDA guidelines. Also called human microdose studies, they have single sub-therapeutic doses given to 10 to 15 subjects and yield pharmacokinetic data or help with imaging specific targets without introducing pharmacological effects. Pharmaceutical companies perform Phase 0 studies to decide which of their drug candidates has the best pharmacokinetic parameters in humans."
The phases of preclinical and clinical trials
While Profil Germany focuses on phase 1+2 clinical trials, a full understanding of the phases of clinical trials is essential.
www.profil.com
Sometimes in phase 1 they literally give people a single dose of a medication. For BAY & Kintor's KX they dosed the back/abdomen of patients with a single doage, no where near the scalp or hair for either one. I would be very surprised if phase 1 was anything more then a patch of hair.Before doing a phase I they do a smaller safety test in humans. This will be where they test 1cm².
"Phase 0 involves exploratory, first-in-human (FIH) trials that are run according to FDA guidelines. Also called human microdose studies, they have single sub-therapeutic doses given to 10 to 15 subjects and yield pharmacokinetic data or help with imaging specific targets without introducing pharmacological effects. Pharmaceutical companies perform Phase 0 studies to decide which of their drug candidates has the best pharmacokinetic parameters in humans."
The phases of preclinical and clinical trials
While Profil Germany focuses on phase 1+2 clinical trials, a full understanding of the phases of clinical trials is essential.
Maybe, maybe not. Nobody here is going to be getting it regardless
Doesn't matter to me, proof of concept is all it takes to get the ball rolling.
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They keep posting.
our brother
)))In other words, moving an occipital hair to the top of the scalp doesn't change the fact that it's resistant to miniaturization.
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So they pretty much know by their own research that hair restoration with multiplication will clear Androgenetic Alopecia out!? That's satisfying and terrifying at the same time... Cool!
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Wait what do you mean clear Androgenetic Alopeicia out, I'm confused lol
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That's probably because they are being taken from areas where the person was already prone to miniaturization (ie the NW5-6 zone) and then get blasted by scalp DHT plus shock damage on move. Even with FUT, I see strip scars in the NW6 zone on the sides all the time.
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Hang around the transplant world for long enough and you hear plenty of those reports. Transplanted hairs thinning and donor area thinning. It's not a consistent thing but it definitely happens. Severe baldness takes no prisoners. The "safe zone" is not 100% safe, it's just being hurt less severely.
Some guys even report their transplanted hairs thinning faster than the rest of the donor hair it came from. It's not unheard-of.
The guys who got early plug grafts (like 4mm chunks) used to report a "donuting" problem where the center of the grafts would bald out compared to the perimeter. I don't think that has ever been explained very well. Just catch-all explanations like "reduced circulation due to scarring". IMO the phenomenon seemed too specific for that to cover it.
Some guys even report their transplanted hairs thinning faster than the rest of the donor hair it came from. It's not unheard-of.
The guys who got early plug grafts (like 4mm chunks) used to report a "donuting" problem where the center of the grafts would bald out compared to the perimeter. I don't think that has ever been explained very well. Just catch-all explanations like "reduced circulation due to scarring". IMO the phenomenon seemed too specific for that to cover it.
Then they have dupa/retrograde or another type of hair loss that extends to the new follicles like a scarring alopecia that was never treated. This isn't a one size fits all.
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I did my part by donating to riken.