Update From The God Himself - Dr. Takashi Tsuji

[razzmatazz91]

Non-clinical trials should be over soon.

They're "pre-clinical" trials on mice.
After that, the human trials should be on! Hope all goes well, Riken has been on schedule so far.

 

[Marcaronii]

They're "pre-clinical" trials on mice.

Yeap, non-clinical trials.

 

[Cymro27]

2019 could well be the year we see cloned (sort of cloned) hair grown on humans. Well I hope it's a happy new year guys.

 

[layabout]

Aren't we going to run into the same problem with "cloned" hair as hair transplants.... i.e., it'll still be impossible to create natural packed density due to necrosis concerns

 

[00000]

Necrosis? Explain in depth how planting cloned hair follicles in the scalp could even potenitally cause Necrosis. THanks.....

 

[layabout]

Necrosis? Explain in depth how planting cloned hair follicles in the scalp could even potenitally cause Necrosis. THanks.....

For the same reason that trying to get a hair transplant with native hair density of 80-100 grafts per sq. cm would cause necrosis and why hair transplant surgeons will never do it

 

[BalderBaldyBald]

Necrosis? Explain in depth how planting cloned hair follicles in the scalp could even potenitally cause Necrosis. THanks.....

Reaching too much density during hair transplants can cause some collateral damages, skin is too much injured to recover and some complications can appear.

Here some examples :



But keep in mind, those injuries are also caused by the size of the grafts, Tsuji's grafts will be much much smaller, and they stated being able to reach a somehow natural density without those complications

Let's wait and see
They are aware of this

 

[alibaba92]

For the same reason that trying to get a hair transplant with native hair density of 80-100 grafts per sq. cm would cause necrosis and why hair transplant surgeons will never do it

How about 2nd or 3rd transplant to add density a year later ? by that time, all the injuries have been fully recovered ?

 

[byebyehair]

Reaching too much density during hair transplants can cause some collateral damages, skin is too much injured to recover and some complications can appear.

Here some examples :

View attachment 108225 View attachment 108226 View attachment 108227

But keep in mind, those injuries are also caused by the size of the grafts, Tsuji's grafts will be much much smaller, and they stated being able to reach a somehow natural density without those complications

Let's wait and see
They are aware of this

Man what a horror show :/

 

[byebyehair]

Aren't we going to run into the same problem with "cloned" hair as hair transplants.... i.e., it'll still be impossible to create natural packed density due to necrosis concerns

normal density is 200 hair cm². And we all know you start seeing balding AFTER you lost half the density. So we should be happy with everithing above 100 hair per cm². And the were able to give the rat 128 hair per cm². That suggests the density will be quite good

 

[Marcaronii]

Happy New year to all my balding bros.

 

[bald fighter]

does any one knows how long will the human trials will last before commercialization the product ?

 

[Cymro27]

Reaching too much density during hair transplants can cause some collateral damages, skin is too much injured to recover and some complications can appear.

Here some examples :

View attachment 108225 View attachment 108226 View attachment 108227

But keep in mind, those injuries are also caused by the size of the grafts, Tsuji's grafts will be much much smaller, and they stated being able to reach a somehow natural density without those complications

Let's wait and see
They are aware of this

That's due to too many, too closely packed in one sitting. And like someone said it's the size of the grafts also, this will be almost like injections. + you could get it done over a few sessions.

As for the trials- my understanding is that they can get to market after a year if it goes well, then although it's on the market it's still under trial like scrutiny for the next 5 or so years.

 

[Trichosan]

2019=========>2020 TSUJI

Just a stones throw away now, gentlemen. I hope good news is on the horizon.

 

[Hate da Bt]

2019=========>2020 TSUJI

Just a stones throw away now, gentlemen. I hope good news is on the horizon.

A few months are left.
Hopefully, progress will have been achieved by the end of 2019.

 

[Cymro27]

I have been wondering. They can grow hair in the lab, they can grow skin in the lab.. why don't they fully grow the follicles on the skin and then transplant them in? Does their skin not have enough layers?

 

[disfiguredyoungman]

I have been wondering. They can grow hair in the lab, they can grow skin in the lab.. why don't they fully grow the follicles on the skin and then transplant them in? Does their skin not have enough layers?

What's the advantage besides having a Frankenstein scar?

Reaching too much density during hair transplants can cause some collateral damages, skin is too much injured to recover and some complications can appear.

Here some examples :

View attachment 108225 View attachment 108226 View attachment 108227

But keep in mind, those injuries are also caused by the size of the grafts, Tsuji's grafts will be much much smaller, and they stated being able to reach a somehow natural density without those complications

Let's wait and see
They are aware of this

Tsuji will not be like a hair transplant. We are not talking traditional grafts here.
Hair follicles from the back are extracted to gain mesenchymal and epithelial cells, these cells are then cultured to create hair follicle germs, which are then to delivered into the scalp. I reckon that these cells could be delivered through injections and not incisions, but to be honest I don't know.

Either way it is a very different procedure and traditional metrics are not applicable.
So far I am only worried about the implications of my retrograde alopecia.

 

[BalderBaldyBald]

What's the advantage besides having a Frankenstein scar?





Tsuji will not be like a hair transplant. We are not talking traditional grafts here.
Hair follicles from the back are extracted to gain mesenchymal and epithelial cells, these cells are then cultured to create hair follicle germs, which are then to delivered into the scalp. I reckon that these cells could be delivered through injections and not incisions, but to be honest I don't know.

Either way it is a very different procedure and traditional metrics are not applicable.
So far I am only worried about the implications of my retrograde alopecia.

Don't forget the nylon threads, but you're right, there's still a whole bunch we don't know yet, but i'm pretty sure they will have to use grafts and not injections here, at least on mice they used grafts IIRC, they also mentioned about their new techniques for such small germs to be placed correctly.

It's also quite possible final procedure is not fully done yet and will evolve during next years and human trials results, i'm quite curious about it, so little data so far, and only Ex-vivos except from that mice experiment.

 

[Cymro27]

What's the advantage besides having a Frankenstein scar?




Tsuji will not be like a hair transplant. We are not talking traditional grafts here.
Hair follicles from the back are extracted to gain mesenchymal and epithelial cells, these cells are then cultured to create hair follicle germs, which are then to delivered into the scalp. I reckon that these cells could be delivered through injections and not incisions, but to be honest I don't know.

Either way it is a very different procedure and traditional metrics are not applicable.
So far I am only worried about the implications of my retrograde alopecia.

I meant grow the hair follicles on lab skin and use that as the donor (fue) picking the best follicles.
Slapping a patch of skin on your head and stitching it up would be madness.

 

[BalderBaldyBald]

A brand new scalp (without calcification and fibrosis and with follicles not affected by DHT) would probably be the actual cure. 10+ years into the future (or more, I am not scientist or some medical person), but a new bioprinted scalp wouldn't need topicals or other drugs and would be a one time cure.

You know why there's not a single product or company in the current pipeline researching on this ? Because it's bullshit
L'Oreal is trying to 4D print follicles, Tsuji is trying to clone healthy follicles, Replicel/Shiseido are trying to kinda reinforce and refill what has been depleted in follicles themselves to quickly popularize.
You do not need a new scalp, you need resistant follicles, or new ones if science can't manage to do this

A real cure, if it's even achievable on a developed human being, will be genetic.

Just stop with this decalcification nonsense @Arrade, this is truly contagious