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Update From The God Himself - Dr. Takashi Tsuji
- Thread starter kingjohn
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As amazing as this is it's really only geared towards those who are a follicle graveyard, wish there was more coming out to help those who are not as bad as that(yet). The price will be enormous too if successful and will take a good 10 years or so to come down i would say. Great hope for those past the point of no return though.
Dude you’re confusing treatments - Tsuji utilises different cells to create a germ that is then implanted . The two types of cells then communicate to form a NEW follicle.
In one of the papers they detailed the implementation on mice where they had to use nylon thread to position the germ to make sure the new follicle grows straight up and not at an angle which remains one of their biggest problems .
The Tsuji video highlights a lot of his methodology.
None of the cells have pumping ability - they’re a very long way off .
haha bro if you're still here in 5 years i'll do it for you. That did make me laugh i will admit.
"Engraftment of the iPS cell–derived 3D IOS
For hair follicle regeneration, the iPS cell–derived hair follicles, which were divided into small pieces containing 10 to 20 hair follicles, were intracutaneously transplanted into the back skin of 6-week-old Balb/c nu/nu mice, as previously described (47). Shallow stab wounds were made on the back skin of nude mice using a 20-gauge Ophthalmic V-Lance (Alcon Japan). The iPS cell–derived 3D IOSs were held so that the hair protruded from the skin surface. The transplantation sites were then covered with surgical bandage tape (Nichiban). To examine the engraftment of the transplants and to study the hair cycles of the bioengineered hairs, we observed all transplanted sites using the SteREO Lumar.V12 and AxioCam fluorescent stereoscopic microscope system (Carl Zeiss). Observations were made every 2 to 3 days."
I still have a hard time finding that nylon thread you are talking about. and for the "printing" of the skin, 3D tissue printing, or what ever this year buzz word is. They don't use nylon thread in any of the methods i have read about. even those where they go from a production time from about 17 hours or so down to 2 minutes.
And the real problem for any transplant is the immune system, Human body rejects foreign materials.
"To eliminate the risk of tissue rejection, Tsuji and his colleagues transplanted the bioengineered skin onto the backs of mice that had been genetically engineered to lack a functioning immune system. In people, however, this kind of transplant would require recipients to take immune-suppressing drugs―unless the tissue could be perfectly immune matched. This would require finding just the right donor or, by using reprogrammed stem cells, growing tailor-made skin from a patient’s own biopsied tissue."
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"The team says their next step is to adapt the approach for clinical applications. Currently available skin grafts made by tissue engineering are generally only one or two cell layers thick and lack the support structures involved in fat secretion, moisturizing and waste excretion. They also do not aesthetically look like normal skin. A three-dimensional, complete integumentary organ offers a better alternative.
But Tsuji and his colleagues first have to ensure that the system they demonstrated with mouse cells also works with human cells. This may be more complex than it might appear, because it is not just a matter of finding the recipe for coaxing human reprogrammed stem cells to form the various appendage organs of the skin—the researchers also have to find a way to make the bioengineered skin entirely in a lab dish without relying on living animals for any step of the process.
Despite the challenges, Tsuji thinks that it is only a matter of time before he will achieve his many objectives. “We hope to begin clinical testing in humans within the next decade,” he says."
Its all written in 2016, it shows that we are still talking about multiple years away just for clinical testing, and its a HOPE to begin within the next decade, its 2020 so 6 years to go if his hope is something to go by.
But Tsuji and his colleagues first have to ensure that the system they demonstrated with mouse cells also works with human cells. This may be more complex than it might appear, because it is not just a matter of finding the recipe for coaxing human reprogrammed stem cells to form the various appendage organs of the skin—the researchers also have to find a way to make the bioengineered skin entirely in a lab dish without relying on living animals for any step of the process.
Despite the challenges, Tsuji thinks that it is only a matter of time before he will achieve his many objectives. “We hope to begin clinical testing in humans within the next decade,” he says."
Its all written in 2016, it shows that we are still talking about multiple years away just for clinical testing, and its a HOPE to begin within the next decade, its 2020 so 6 years to go if his hope is something to go by.
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It's Clascoterone lol , not Glascoterone. Like the 3rd time u say that.
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No, it's just another pokemon.
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What does it even matter. Dutasteride + hair transplants = hair for 20 years ez.
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Pure and utter cope again of the baldcel himself.
Ez
This video is titled shiseido but actually details Tsuji . I believe a part 1 video somewhere was shiseido :
and what is the video for?
its from a time with replicel, and older than the quotes i brought up.
Funny.. talking about Tsuji... on the Tsuji thread.
The way of creating follicles hasn't changed and demonstrates the observation that when Mesenchymal cells and Epithelial cells come together they communicate to form a hair matrix that generates a brand new follicle. Its termed as regeneration but its not the regeneration of old follicles. If it was old follicles then the topic of intended density wouldn't exist.
This is a screenshot from Tsuji's book ( Organ Regeneration Based on Development Biology)
- 2017 which i assume remains relevant.
Also what i found interesting was their mention of normal FUT procedures offering 60 hairs/cm2 whilst this method achieving 124 +-12 / cm2. I believe normal density in a non balding person is about 200-250
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i have linked to a study about 3d printing many times about the whole thing that tsuji is doing (or trying too)
the problem with high density transplants (225 cm2), is that you don't have the blood flow for it in your scalp, so its another thing that needs to be taken are off.
We are beyond what tsuji is doing, what we aren't beyond is still the basic problems that is introduced in the first place. Not enough blood flow hair follicles dies. So no need to have a trillion hair follicles if they can't stay on your scalp, so the REGENERATIVE research is about to get you as far as they can back to square one, instead of postponing the real problem.
It also take us away from immune system trying to reject your transplants. (there is a reason they use animal models with close to none immune defence)
True, went from about +17 hours for the 3d printing to about 2 minutes for 1 cm3.
The breakthroughs are out there, but tsuji aren't the one in the lead. because no proof of concept in humans
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There will be a Academic Forum poster display of Takashi Tsuji at the lifestyle expo next week 21.01:
RIKEN, TAKASHI TSUJI ...............
https://www.lifestyle-expo-spring.j...ents/2020/en/02-visit/LSsp_en_20_map_1227.pdf
RIKEN, TAKASHI TSUJI ...............
https://www.lifestyle-expo-spring.j...ents/2020/en/02-visit/LSsp_en_20_map_1227.pdf
@Kosteece Tsuji is the only credible player in the game right now? Over the last several months I've really lost any hope I had that this will be anything for me. We're now looking at another handful of years at the least until this would be available, and the cost will be insanely outrageous. Sounds like a total non-option for me. TissUse/J Hewitt Smart Hair Transplant seems much more realistic and doable now.
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Need our man in Japan in there. Find out what's going on. Somebody call Fuji on his shoe phone.