If you’re on finasteride, DHT cream would still be effective since the androgen receptors aren’t blocked and only the T—>DHT conversion is inhibited. In ideaman’s case though, using darolutamide at a high enough dose could possibly block all potential ARs.
Using Topical Dht Cream While On Finasteride Greatly Reduces Risk Of Penile Shrinkage Or Atrophy
- Thread starter strandman
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If you’re on finasteride, DHT cream would still be effective since the androgen receptors aren’t blocked and only the T—>DHT conversion is inhibited. In ideaman’s case though, using darolutamide at a high enough dose could possibly block all potential ARs.
I already read a lot that 0,5 mg or 1/1,25 mg of fina per day has probably the exact same effect on DHT, but not as low as 0,1 mg :O ..
how are you able to cut a pill in 10 exact pieces.. !?
Very carefully haha
Awesome thanks. Good to know. Any DHT-dick studies you can find would be appreciated.
Also, how is your libido doing on darolutamide? Any changes?
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where do you get your darolutamide? wouldnt mind giving it a go
damm i would need a very sharp and little knife to cut 1 mg in 10 hahaha !
Dont you think it would easier to buy raw finasteride powder from kane shop and just take the amount you need daily ?
I was going to do that but now I’m probably going to switch to topical bicalutamide or darolutamide, or possibly even CB.
Yeah i just went on kaneshop and saw darolumatide but i dont anything about this medecine and efficiency, and even if, it looks too expensive for me haha
I don’t see darolutamide listed anywhere on kaneshop. Are you sure you didn’t accidentally mistake dutasteride for darolutamide?
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Anyone can see the darolutamide thread if you want to learn about darolutamide. The first 10-20 pages I think are the most on topic. Keep in mind this is an experimental compound not yet approved for human use.
Did you consider using any of the other
“-utamide” medications? Like bicalutamide or enzalutamide?
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No. I came to this point of my desperation after RU and during spironolactone/cypro. I got talked into the importance of enza/daro by @whatevr in the enza thread. Then I saw JLF's daro thread, recognized its incredibly unique profile (highest raw power + doesn't cross the blood brain barrier) and I was sold.
In principle any other -utamide (androgen receptor antagonist) would probably work just as well in a topical as long as you can dissolve enough of it. Those other agents are much weaker than daro and would need higher concentration for equal effect. Those other drugs would also give messier side effects by crossing the blood-brain barrier more.
I consider myself lucky to have come to this site while daro was a topic of discussion and lucky to have been able to make it work.
It's not perfect, but it's the best treatment I've had so far.
And your libido hasn’t decreased at all while on it?
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Zero. It was a point of interest to me to see what would happen there, because spironolactone and cypro nuked my sexual function completely. High doses of estriol cream also affect my sexual function.
But even with the highest doses of daro I used, where the systemic anti-androgenism was so great as to dry up all the sebaceous/sweat glands in my entire body and turn my eyes bloodshot from dryness, there have been no sexual side effects.
This has really proved for me that sexual side effects are the result of anti-androgens affecting sexual circuits of the brain, or messing with hormone levels in ways that affect the circuits of the brain.
Because daro does not cross the blood-brain barrier, it does not in any way interfere with the natural balance of your hormones (hormone levels should be unchanged on daro) and the sexual centers of the brain work fine.
I was worried the androgen blockade would shut my dick's erectile function down by working negatively on the dick directly but that never happened. I do think there is a legit risk of penile atrophy long term. But otherwise everything works fine on daro and I feel fine except a bit of dry eyes when I use too much. It's been exceedingly clean of a drug considering its strength.
Nothing for treating this condition is perfect. I would love a perfect method. But I think daro is the best I will get, and I can make it work in the long run.
Wow I may just have to get on daro now. I researched bicalutamide extensively as a topical agent due to its ability to preserve sexual function and libido while being a powerful AA elsewhere in the body. I’m going to research the similarities and differences between darolutamide and bicalutamide then make a decision.
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Read the first 20 pages of the daro thread and you should get sufficient answers. Also approximate strength comparison is here:
https://www.hairlosstalk.com/intera...conversion-of-ru58841-to-darolutamide.109065/
Maybe, when you apply your T gel, wait first until your last daro dose finishes its half life before gel application, then take your daro dose soon after. This window of time should be prime for using the gel and having free androgen receptors in the genitals for the T to dock to.
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Agonism and antagonism is all about competitive equilibrium.
I apply my daro twice a day and absorption from the scalp into the blood should be a relatively slow and steady process. Plus daro has a reasonably decent half life, so I expect I have a relatively steady state of daro in my blood at all times.
This daro is not a large amount. It's just enough to give me a bit of eye dryness at worse, and possibly inhibit some small percent of my androgen receptors through the rest of the body as well. I apply 6 mg per day to my scalp. In prostate cancer the dose is up to hundreds of mg per day orally. So I am using a tiny amount.
Certainly at any given time most of my androgen receptors in my dick (as with everywhere else) should therefore be daro free.
Adding more DHT/test locally to the dick would increase androgen signalling by hammering all those free receptors with positive stimulation. In high enough concentrations, a large amount of DHT could even outcompete a small amount of daro for the receptors, but you'd probably need a lot of DHT and very little daro.
Mostly I would conceptualize the topical DHT/test as maximizing use of the non-daro bound androgen receptors, which, unless I'm heavily overdosing myself on daro, should be the vast majority.
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I’ve read before that finasteride has a stacking effect in the blood, meaning that even low doses, when taken everyday, will “stack” in the bloodstream until it’s inhibiting the same amount of DHT as higher doses. finasteride takes 2-3 days to leave the body, so taking a small dose everyday would allow a surplus to continuously build in the blood. I could very well be wrong but this is something I’ve read about before.