We Now Have A Cb-03-01 Vehicle That Works

[Mustang]

That's exactly what I was trying to explain but the dude thinks he knows better just because he spent 80k on 13 transplants!!!

That is exactly how it works.

This is painful to read

2 idiots don't make 1 smart man.

 

[Mustang]

Thinking you can get the same results from 2% minoxidil as 5% if you just use 2.5x as much lol. It doesn't work that way.

That is exactly how it works on the same surface with a drug that does not go systemic.

 

[Mustang]

Alright Newton and Einstein.

Let's say John applies 2ML of 0.1% Topical Finasteride in his crown which measures 5 square cm.

How many milligrams of Finasteride has John applied onto his scalp?

According to you he has applied 1mg
According to me he has applied 2mg

I wonder who is right.

 

[pegasus2]

Why do they even sell 5% minoxidil? Why not just use 2%, but use more, or vice versa? If your goal is to get the drug to go systemic then that would work, but our goal is to get a 5% concentration to the DP. Yes, the concentration matters. The difference in efficacy is not linear, but you get more drug to the follicle with a higher concentration than with a lower concentration, even though the total amount of the drug applied is the same. Only so much solution can occupy the same space at one time. Doubling the amount of solution that you apply to your scalp does not double the amount of solution in the hair follicle. Doubling the concentration does double the amount of drug in the hair follicle. This is why when you read studies they give the concentration, usually in μM or nM, and not the amount of the drug. You need to use enough volume of solution to saturate the follicle, and use it at the effective concentration. Both are required.

 

[Mustang]

Why do they even sell 5% minoxidil? Why not just use 2%, but use more, or vice versa? If your goal is to get the drug to go systemic then that would work, but our goal is to get a 5% concentration to the DP. Yes, the concentration matters. The difference in efficacy is not linear, but you get more drug to the follicle with a higher concentration than with a lower concentration, even though the total amount of the drug applied is the same. Only so much solution can occupy the same space at one time. Doubling the amount of solution that you apply to your scalp does not double the amount of solution in the hair follicle. Doubling the concentration does double the amount of drug in the hair follicle. This is why when you read studies they give the concentration, usually in μM or nM, and not the amount of the drug. You need to use enough volume of solution to saturate the follicle, and use it at the effective concentration. Both are required.

No.

Minoxidil does not act on the hair follicle.

It expands potassium channels as a vasodilator allowing more bloodflow towards the follicle therefor thickening existing hair by the increase of oxygen and nutrients. If you apply 1ML of 5% minoxidil into a 5 square cm2 area or 2ML of 2.5% you will have applied the same amount of the drug and the results will be identical.

 

[pegasus2]

No.

Minoxidil does not act on the hair follicle.

It expands potassium channels as a vasodilator allowing more bloodflow towards the follicle therefor thickening existing hair by the increase of oxygen and nutrients. If you apply 1ML of 5% minoxidil into a 5 square cm2 area or 2ML of 2.5% you will have applied the same amount of the drug and the results will be identical.

Sigh. Why don't all vasodilators cause hair growth? Even most K+ channel openers don't cause growth. There are many MoA for minoxidil. I'm not going to get into them all, but here's one study

"Minoxidil directly promotes hair growth via the stimulation of dermal papilla (DP) and epithelial cells."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877552/

Anyways, that is off topic. Minoxidil was just an example. Let's replace minoxidil with CB and use the same principle. I hope you'll at least agree that CB works by binding to the AR in the hair follicle. If it needs to do that then surely you can understand how more solution is not going to be equivalent to a higher concentration when the hair follicle is already or near saturated. You really are not very bright if you can't understand that.

 

[Mustang]

Sigh. Why don't all vasodilators cause hair growth? Even most K+ channel openers don't cause growth. There are many MoA for minoxidil. I'm not going to get into them all, but here's one study

"Minoxidil directly promotes hair growth via the stimulation of dermal papilla (DP) and epithelial cells."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877552/

Anyways, that is off topic. Minoxidil was just an example. Let's replace minoxidil with CB and use the same principle. I hope you'll at least agree that CB works by binding to the AR in the hair follicle. If it needs to do that then surely you can understand how more solution is not going to be equivalent to a higher concentration when the hair follicle is already or near saturated. You really are not very bright if you can't understand that.

Many vasodilators cause hair growth, for example, Cialis. I have successfully used a few and there are several studies to back this up.

Nobody is disputing what CB does. You are mixing oranges with apples.

2.5% 2ML vs 5% 1ML on the same area will have the same outcome. Period.

If you can't understand that then we are both not very bright. Let's move on.

 

[pegasus2]

Many vasodilators cause hair growth, for example, Cialis. I have successfully used a few and there are several studies to back this up.

Nobody is disputing what CB does. You are mixing oranges with apples.

Yes, many do, but not all or even the majority of them, and none of them are as potent minoxidil at promoting hair growth.

 

[Mustang]

Agreed

 

[John Difool]

I got Nizoral 1% shampoo OTC in the States. Following your reasoning why is FDA requiring a prescription for Nizoral 2% if I can get away with twice the application? Doesn't it have anything to do with concentration and what @pegasus2 was trying patiently to explain to you?

There are other factors involved:

• Higher concentrations of the active ingredient may penetrate more than lower concentrations

The rest of the article is pretty instructive about skin absorption
https://dermnetnz.org/topics/topical-formulations/

 

[Seuxin]

Yeah, using twice 1% is totally not the same than using 2%

 

[Mustang]

Ehhhh, yes it is.

If I go to the doctor and he asks me how much topical Dutasteride do you use my answer would be the equivalent in milligrams.

I use 2ML at 0.1% thus I apply 2mg of Dutasteride. I really find it hard to believe you find this so difficult to understand.

 

[John Difool]

Reread @pegasus2 post on skin absorption.

There is another thread on WinLevi (CB 1% for acne). Someone suggested applying 7.5 times the amount of the cream instead of waiting for Breezula (CB 7.5% for hair). It won't work. Go read it and maybe you will see the light. Good luck!