what is CB0301' condition now?
- Thread starter Jamesallenliwei
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How do you know this? Do you have a source?
resu
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Yes it's on Cosmo site, they only started the trials after they finalized the vehicle, we still don't know the results and if it's even going into phase II.
they didn't use iontophoresis? :unsure:
i can't find what you said in the cosmo's site, any link? thanks,
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They did. however is not feasible for us to do as the costs for it are way out of reach. Basically, if you had the money for Iontophoresis, you wouldnt be on this forum and the money you'd have in your account would probably make you not give a crap about your hair.
cthulhu2.0
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haha, so true.
resu
Senior Member
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http://www.cosmopharmaceuticals.com/~/media/Files/C/Cosmo-Pharmaceuticals/pipeline-04-13.pdf
http://www.cosmopharmaceuticals.com/~/media/Files/C/Cosmo-Pharmaceuticals/product_pipeline_03_14.pdf
As you can see it's been on hold since 2012, only now will they start phase II for Androgenetic Alopecia.
I can't find the exact news where they mention the vehicle and no they didn't specify what type of vehicle, marklc2004 on HLH keeps mentioning it's gel based but I don't know where he got that info from.
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Desmond from BTT proposed the following vehicle:
Desmond84 said:Hey guys, so as promised here's a proposed vehicle for CB-03-01:
1) Ceteareth-20 (5%): is a penetration enhancer which alters the skin structure, allowing substances to penetrate deeper into the skin. It will help CB dissolve better and stay in the vehicle during storage.
2) Oleyl alcohol (10%): either of these will do as the solvent/emulsion stabiliser. I did a bit of reading on CB-03-01 properties and it seems to definitely be soluble in DMSO. DMSO is not a good solvent for long-term use and has had some possible deaths associated with its use! So after digging around a bit I thought either of these should be a decent replacement. Has anyone been able to dissolve CB in alcohol? Plz let me know asap...thx
3) Dimethicone 200 (5%): keeps the skin moist and improves absorption. A lot of topicals have this added to ensure optimal absorption.
4) Glyceryl monostearate (2%): should help CB dissolve in alcohol and will also act as a preservative.
5) Methyl Hydroxybenzoate (2%): is also a common preservative added. We wanna make sure these expensive batches have long enough shelf expiry.
6) Phenoxyethanol (2%): is also a preservative with bacteriostatic properties. It is generally combined with methyl hydroxybenzoate to provide a broad bacteriostatic protection againsts a range of microbes.
7) Propyl Hydroxybenzoate (2%): is another preservative used against fungal growth.
8) Stearyl alcohol (5%): this is not a must but may help with absorption.
9) Sodium hydroxide (2%): this is a chemical buffer to adjust the pH to around 5.5 (skin pH). This way our lotion wont sting when we apply it.
10) Emu oil (to 100mL): this is simply to increase absorption deep into the dermal layer! And is a great substitute for mineral oils which seems to be bad for hair
11) CB-03-01: (1-2%)
_______________________________________________________________
Preparation:
Step 1. Dissolve CB-03-01 in Oleyl alcohol.
Step 2. Add Ceteareth-20 and Stearyl alcohol. Stir until all powder is dissolved.
Step 3. Add the remaining ingredients.
_______________________________________________________________
That's pretty much it. If you guys have any feedback please let me know.
P.S. I removed some ingredients that I originally proposed since they were not necessary in this formulation.
Cheers
I have high expectations of CB.
What do you guys think, how much regrowth, if any, would be possible with it?
I'm a NW2 at the moment, but I could easily move towards NW3 by the time this stuff hits the market.
I guess I'm just gonna sit and religiously wait for that to happen.
I'm too scared by the sides from finasteride, anyway.
What do you guys think, how much regrowth, if any, would be possible with it?
I'm a NW2 at the moment, but I could easily move towards NW3 by the time this stuff hits the market.
I guess I'm just gonna sit and religiously wait for that to happen.
I'm too scared by the sides from finasteride, anyway.
cthulhu2.0
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I was actually in the same boat as you, worried about taking finasteride and hoping for a soon release of cb. The reality is cb-03-01 won't be released in the next few years because of the snail-like pace fda trials require and the fact that it is currently further in the trials for acne, which could be another obstacle. One more thing, I don't know if you remember how expensive propecia was before the generics came out last year but expect cb-03-01 to probably be even more expensive since it is a topical and promises less sides. Even worse, these patents can last a really long time although I am not exactly sure at the moment how long they last. Overall, my opinion of finasteride is that it is safe, and keep in mind that I currently take it. It passed fda trials with flying colors not only for bph but Androgenetic Alopecia, and with only 5% of patients experiencing sides.
Hey, thanks for the quick reply!
Yeah, when you put it that way, it does sound like a long way to go for CB. I was kinda hoping, at first, for the acne version to be usable with an appropriate vehicle or something. I don't know if that seems plausible or not.
As for the finasteride, I was thinking of giving it a go with smaller dosage than usual, but I never seem to get it all figured out and finally do it. It's silly, I guess...
Depends on how it would work. Blocking DHT instead of inhibiting is the future of male pattern baldness treatment anyway.
I.D WALKER
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Kudos to Desmond, our ever roving and faithful In House Chemist.
JZA70
Banned
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- 59
cthulhu2.0
Established Member
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Are you certain of this? I'm almost sure I saw it at Walmart a month ago. It was next to the cat nip if I recall correctly.
- - - Updated - - -
Ive got fantastic news!!! Target is doing a 2 for 1 on cb when you purchase "Petco" brand cat nip.
What's wrong? It's not the same.
JZA70
Banned
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Explain...
When he said inhibiting, he probably meant inhibition of the production of DHT. Systemically, this is a huge problem because of side effects. The way to go would be to block DHT by occupying androgen receptors locally selectively, e.g. in the scalp. That way, you could keep your body's 5ar (5 alpha reductase, which produces the DHT) untouched, while still eliminiating the negative effects of DHT selectively in your scalp.
Finasteride, for example, inhibits DHT (production) by occupying 5ar, preventing T from docking to 5ar. T docked to 5ar is being converted by 5ar to DHT. The problem is that finasteride, the active ingredient of propecia, works systemically and thus also shuts down DHT production in your testicles, for example. And you dont want that.
Finasteride, for example, inhibits DHT (production) by occupying 5ar, preventing T from docking to 5ar. T docked to 5ar is being converted by 5ar to DHT. The problem is that finasteride, the active ingredient of propecia, works systemically and thus also shuts down DHT production in your testicles, for example. And you dont want that.